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Mostrando 681 - 700 Resultados de 722 Para Buscar '"human condition"', tiempo de consulta: 0.39s Limitar resultados
  1. 681
    “…Given that gene expression levels in LPS stimulated macrophages is routinely used to infer biological phenomena that are of relevance to human conditions, verification of reference gene expression stability is crucial. …”
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    Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages
  2. 682
    “…We review several key aspects that impact external validity in preclinical animal research, including unrepresentative animal samples, the inability of animal models to mimic the complexity of human conditions, the poor applicability of animal models to clinical settings and animal–human species differences. …”
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    Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail
  3. 683
    “…Hence, the present study is aimed at investigating the role of c-Met and the interaction with the oxidative stress response during NASH development in mice and humans. Conditional c-Met knockout (KO) lines (LysCre for Kupffer cells/macrophages, GFAPCre for α-SMA(+) and CK19(+) cells and MxCre for bone marrow-derived immune cells) were fed chow and either methionine-choline-deficient diet (MCD) for 4 weeks or high-fat diet (HFD) for 24 weeks. …”
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    c-Met Signaling Protects from Nonalcoholic Steatohepatitis- (NASH-) Induced Fibrosis in Different Liver Cell Types
  4. 684
    “…To unravel molecular renal proximal tubular NTBI and TBI handling, human conditionally immortalized proximal tubular epithelial cells (ciPTECs) were incubated with (55)Fe as NTBI and fluorescently labeled holo-transferrin as TBI. …”
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    Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells
  5. 685
    “…They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might conversely fuel synovitis and enthesitis. …”
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    Bone marrow mesenchymal stem cells in rheumatoid arthritis, spondyloarthritis, and ankylosing spondylitis: problems rather than solutions?
  6. 686
    “…They have been increasingly proven to act as potential natural agents in the treatment of several human conditions, including diabetes mellitus (DM). DM is a metabolic disorder characterized by chronic hyperglycemia closely related to carbohydrate, protein and fat metabolism disturbances. …”
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    Sucupira Oil-Loaded Nanostructured Lipid Carriers (NLC): Lipid Screening, Factorial Design, Release Profile, and Cytotoxicity
  7. 687
    “…Human umbilical vein endothelial cells (HUVEC) and human conditionally immortalized proximal tubular epithelial cells (ciPTEC) were seeded into the tubular scaffolds and tested for monolayer formation, integrity, and organization, as well as for extracellular matrix (ECM) production and renal transport functionality. …”
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    Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance
  8. 688
    “…FH/FHR binding to human conditionally immortalized glomerular endothelial cells (ciGEnCs) and HS(Glx) purified from ciGEnC glycocalyx was assessed. …”
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    Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies
  9. 689
    “…Genetic mutations identified in genome-wide association studies can only explain a small percentage of the cases of complex, highly heritable human conditions, including neurological and neurodevelopmental disorders. …”
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    Thyroid hormone elicits intergenerational epigenetic effects on adult social behavior and fetal brain expression of autism susceptibility genes
  10. 690
    “…Although considered a gold standard biomarker in some human conditions, the utility of 15‐F(2t)‐Isoprostanes (15‐F(2t)‐Isop) in detecting oxidative stress in dairy cattle has not been validated. …”
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    15‐F(2t)‐Isoprostane Concentrations and Oxidant Status in Lactating Dairy Cattle with Acute Coliform Mastitis
  11. 691
    “…Because human mutations in COE orthologs lead to neurodevelopmental disorders characterized by motor developmental delay, our findings may advance our understanding of these human conditions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13064-018-0125-6) contains supplementary material, which is available to authorized users.…”
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    An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development
  12. 692
    “…Moreover, mutations in some of these genes are involved in different human conditions ranging from tinnitus to epilepsy and hyperekplexia, suggesting distinct functions of the different subunits. …”
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    Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish
  13. 693
    “…Particularly, how these systems can help people improve human conditions of health, by taking advantages of the new Information and Communication Technologies (ICT), regarding early prediction and efficient treatment. …”
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    Syndromic surveillance using web data: a systematic review
  14. 694
    “…BACKGROUND: Alternative splicing (AS) is important in the regulation of gene expression and aberrant AS is emerging as a major factor in the pathogenesis of human conditions, including cancer. Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer with strong invasion, high rate of metastasis, and poor prognosis. …”
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    Novel Insights Into Triple-Negative Breast Cancer Prognosis by Comprehensive Characterization of Aberrant Alternative Splicing
  15. 695
    “…Since then, an increasing number of publications have reported the involvement of LRG1 in multiple human conditions including cancer, diabetes, cardiovascular disease, neurological disease, and inflammatory disorders. …”
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    LRG1: an emerging player in disease pathogenesis
  16. 696
    “…While these analyses provide lists of molecular alterations in human conditions, like Alzheimer's disease (AD), identifying individual proteins that affect biological processes remains a challenge. …”
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    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
  17. 697
    “…Additionally, we reviewed knockout animal models that exhibit phenotypic similarities to human conditions. Moreover, we analyzed reported variants in candidate genes and explored their association with corresponding phenotypes. …”
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    A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome
  18. 698
    “…Loss-of-function mutations in either protein results in autosomal recessive forms of blindness. Modeling these human conditions using RPE65 or CRALBP murine knockout models have enhanced our understanding of their biochemical function, associated disease pathogenesis and development of therapeutics. …”
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    Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish
  19. 699
    por Sung, Kijung, Yang, Wanlin, Wu, Chengbiao
    Publicado 2019
    “…The significance of these findings is at least two folds: 1) the NGF(R100W) mutation can be used as an alternative to the wildtype NGF to treat human conditions without eliciting pain; and 2) the 75 kDa neurotrophic factor may serve as a novel target for pain management. …”
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    Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?
  20. 700
    “…In recent years, the medical use of cannabis has been approved in different countries for a variety of human conditions. However, the use of these compounds, specifically as anticancer agents, remains controversial. …”
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    The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology
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