“…The latter do not recapitulate the human condition, making it difficult to compare levels of sphingolipids found in animal tissues and human bodily fluids, and thus, to find definitive conclusions. …”
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“…Here, we shortly review evidence showing that these relationships do exist, which supports the assumption that political orientation is deeply rooted in the human condition. Potential reasons for the premature rejection of these relationships and directions for future research are outlined and implications for refinements and extensions of evolutionary informed approaches are derived.…”
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“…Sartre adds universal depth to Schwab’s portrait of teachers, proving them to be an extreme expression of the human condition. Schwab provides Sartre’s analysis with concrete validation and practical suggestions for implementation. …”
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“…DeBakey’s principles and practices of weaving science, technology, and the humanities to form holistic understanding of the human condition, inspiring well-rounded careers built on both scientific and humanistic knowledge.…”
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“…It describes how structural racism leads to inefficiencies in idea generation, technological development, training, and career progression in our science, limiting its ability to fully discover the role of affect in the human condition. It briefly describes the content of the special issue, and attempts to start a dialogue about best practices for inclusive science.…”
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“…Postmenopausal aging has become relevant for understanding health during the transition life stages—the aging process being involved in several disturbances of the human condition. The present study aimed to investigate the relationship between postmenopausal aging and sociodemographic, anthropometric, body composition, nutritional, and biochemical (i.e., protein and lipid profiles, phosphorous-calcium metabolism, and antioxidant status) factors in postmenopausal women. …”
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“…Ebolavirus (EBOV) is a virulent pathogen that causes Ebola virus disease (EVD), which is a life-threatening human condition with a fatality rate of up to 90%. Since the first outbreak in Africa in 1976, several outbreaks and epidemics of EBOV have occurred across the globe. …”
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“…Alternatively, the Janus face metaphor moves away from a linear techno‐determinist model and focuses on the dynamic interaction of the human condition and technology. Specifically, it can be used to understand variance in adoption or successful use of diabetes‐related technology and to retrospectively understand suboptimal outcomes. …”
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“…This review examines the current mouse models of chronic hypertension, pregestational diabetes, and obesity that subsequently develop preeclampsia-like symptoms and discusses how closely these models recapitulate the human condition. Finally, we propose an avenue to expand the development of mouse models of preeclampsia superimposed on chronic comorbidities to provide a strong foundation needed for preclinical testing.…”
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“…In showing that such a drift is prompted by a certain use of language, I hope to elucidate some ways in which scepticism is lived and is thus not merely an intellectual conundrum, but an ordinary human condition.…”
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“…To inform a different perspective on relational ethics, we also discuss how accompaniment refers to the clinician’s awareness of the human condition and its existential limits.…”
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“…This suggested to us an explanation for adipose tissue loss in partial lipodystrophy, a rare human condition usually associated with the immunoglobulin G(IgG) autoantibody nephritic factor (NeF) which leads to enhanced alternative pathway activation in vivo. …”
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“…Yet the prospect of treating ageing is extraordinary in terms of the profound changes to the human condition that would result. Recent advances in biogerontology allow a clearer view of the ethical issues and dilemmas that confront humanity with respect to treating ageing. …”
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“…Dysfunctions of ClC-K channels result in Bartter syndrome, an inherited human condition characterized by impaired urinary concentration. …”
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“…For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. …”
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“…DISCUSSION: Medical humanities can offer an insight into human illness and in a broader outlook into human condition, understanding of one self, responsibility. …”
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“…One step in the critical pathway for the development of a new agent for adjuvant treatment of sepsis is evaluation in an appropriate animal model of the human condition. Unfortunately, the animal models that have been used for this purpose have often yielded misleading findings. …”
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“…Finally, we compare the behavioral phenotypes to the human condition of mild to severe zinc deficiency and provide a model, how zinc deficiency that is associated with many neurodegenerative and neuropsychological disorders might modify the disease pathologies.…”
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“…While animal models are useful for studying the etiology of autoimmune disorders, most of the existing animal models of AIH do not recapitulate the chronic course of the human condition. In addition, approaches to mimic AIH-associated liver inflammation have instead led to liver tolerance, consistent with the high tolerogenic capacity of the liver. …”
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“…The success of a small animal model to study critical illness is, in part, dependent on the ability of the model to simulate the human condition. Intra-tracheal inoculation of a known amount of bacteria has been successfully used to reproduce the pathogenesis of pneumonia which then develops into sepsis. …”
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