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693041por Gorman, Ellen, Shankar-Hari, Manu, Hopkins, Phil, Tunnicliffe, William S., Perkins, Gavin D., Silversides, Jonathan, McGuigan, Peter, Jackson, Colette, Boyle, Roisin, McFerran, Jamie, McDowell, Cliona, Campbell, Christina, McFarland, Margaret, Smythe, Jon, Thompson, Jacqui, Williams, Barry, Curley, Gerard, Laffey, John G., Clarke, Mike, O’Kane, Cecilia, McAuley, Daniel F.“…INTERVENTION AND COMPARATOR: Intervention: Allogeneic donor CD362 enriched human umbilical cord derived mesenchymal stromal cells (REALIST ORBCEL-C) supplied as sterile, single-use cryopreserved cell suspension of a fixed dose of 400 x10(6) cells in 40ml volume, to be diluted in Plasma-Lyte 148 to a total volume of 200mls for administration. …”
Publicado 2020
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693042por Li, Jian, Pega, Frank, Ujita, Yuka, Brisson, Chantal, Clays, Els, Descatha, Alexis, Ferrario, Marco M., Godderis, Lode, Iavicoli, Sergio, Landsbergis, Paul A., Metzendorf, Maria-Inti, Morgan, Rebecca L., Pachito, Daniela V., Pikhart, Hynek, Richter, Bernd, Roncaioli, Mattia, Rugulies, Reiner, Schnall, Peter L., Sembajwe, Grace, Trudel, Xavier, Tsutsumi, Akizumi, Woodruff, Tracey J., Siegrist, Johannes“…CONCLUSIONS: We judged the existing bodies of evidence for human evidence as “inadequate evidence for harmfulness” for the exposure categories 41–48 and 49–54 h/week for IHD prevalence, incidence and mortality, and for the exposure category ≥55 h/week for IHD prevalence. …”
Publicado 2020
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693043por Xia, Shengli, Zhang, Yuntao, Wang, Yanxia, Wang, Hui, Yang, Yunkai, Gao, George Fu, Tan, Wenjie, Wu, Guizhen, Xu, Miao, Lou, Zhiyong, Huang, Weijin, Xu, Wenbo, Huang, Baoying, Wang, Huijuan, Wang, Wei, Zhang, Wei, Li, Na, Xie, Zhiqiang, Ding, Ling, You, Wangyang, Zhao, Yuxiu, Yang, Xuqin, Liu, Yang, Wang, Qian, Huang, Lili, Yang, Yongli, Xu, Guangxue, Luo, Bojian, Wang, Wenling, Liu, Peipei, Guo, Wanshen, Yang, Xiaoming“…We aimed to assess the safety and immunogenicity of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidate, BBIBP-CorV, in humans. METHODS: We did a randomised, double-blind, placebo-controlled, phase 1/2 trial at Shangqiu City Liangyuan District Center for Disease Control and Prevention in Henan Province, China. …”
Publicado 2021
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693044por Diorio, Caroline, McNerney, Kevin O, Lambert, Michele P., Paessler, Michele, Chase, Julie, Gollomp, Kandace, Laskin, Benjamin L, Vella, Laura A, Henrickson, Sarah E, Liebling, Emily, Burudpakdee, Chakkapong, Lee, Jessica, Balamuth, Fran, Blatz, Allison M, Chiotos, Kathleen, Fitzgerald, Julie C, Giglia, Therese, Odom John, Audrey R, Petrosa, Whitney, Sullivan, Kathleen, Witmer, Char M, Bassiri, Hamid, Behrens, Edward M, Teachey, David T.“…Proinflammatory cytokines were measured using V-Plex Pro-inflammatory Panel 1 Human Kits and analyzed on a QuickPlex SQ120. P-values were computed using Dunn's multiple comparisons test after Kruskal-Wallis testing. …”
Publicado 2020
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693045por Wang, Zheng, Groen, Henk, Van Zomeren, Koen C, Cantineau, Astrid E P, Van Oers, Anne, Van Montfoort, Aafke P A, Kuchenbecker, Walter K H, Pelinck, Marie J, Broekmans, Frank J M, Klijn, Nicole F, Kaaijk, Eugenie M, Mol, Ben W J, Hoek, Annemieke, Van Echten-Arends, JannieEnlace del recurso
Publicado 2021
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693046por Zeng, Gang, Wu, Qianhui, Pan, Hongxing, Li, Minjie, Yang, Juan, Wang, Lin, Wu, Zhiwei, Jiang, Deyu, Deng, Xiaowei, Chu, Kai, Zheng, Wen, Wang, Lei, Lu, Wanying, Han, Bihua, Zhao, Yuliang, Zhu, Fengcai, Yu, Hongjie, Yin, Weidong“…The main outcomes of the study were geometric mean titres (GMTs), geometric mean increases (GMIs), and seropositivity of neutralising antibody to SARS-CoV-2 (virus strain SARS-CoV-2/human/CHN/CN1/2020, GenBank accession number MT407649.1), as analysed in the per-protocol population (all participants who completed their assigned third dose). …”
Publicado 2022
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693047por Rossi, Jean-Francois, Chiang, Hao-Chun, Lu, Zhao-Yang, Levon, Kalle, van Rhee, Frits, Kanhai, Karan, Fajgenbaum, David C, Klein, Bernard“…Previously, we developed the first anti-IL-6 monoclonal antibody (mAb) treatments and showed that C-reactive protein (CRP) production could be fully controlled by IL-6 in humans. Using mathematical modeling, with CRP as an IL-6 surrogate marker, we predicted the ability of an anti-IL-6 mAb to block plasma IL-6 activity and showed IL-6 inhibition was dependent on the extent of whole-body IL-6 production. …”
Publicado 2021
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693048por Javed, Farhan, Fayyaz, Harris, Al-Abadi, Eslam, Pickering, Warren, Leandro, Maria, Jeffery, Rachel“…Allergy to rituximab (Mabthera) prevented its further use; given the severity of reaction concerns, other biosimilar humanized anti-CD20 antibodies were considered, but difficult to obtain; deteriorating renal function with predominantly damaged kidneys and class V nephritis on biopsy and aiming to control immunology along with other active symptoms (arthritis, serositis–pleurisy, systemic symptoms, anaemia) options were limited. …”
Publicado 2021
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693049por Becker, Christian M, Bokor, Attila, Heikinheimo, Oskari, Horne, Andrew, Jansen, Femke, Kiesel, Ludwig, King, Kathleen, Kvaskoff, Marina, Nap, Annemiek, Petersen, Katrine, Saridogan, Ertan, Tomassetti, Carla, van Hanegem, Nehalennia, Vulliemoz, Nicolas, Vermeulen, NathalieEnlace del recurso
Publicado 2022
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693050por Yang, Guang, Zhou, Siyuan, He, Haoqiang, Shen, Zinuo, Liu, Yongmei, Hu, Jun, Wang, Jie“…Like “disease” is used in western medicine, “syndrome” is used in TCM to comprehend anomalous human conditions on the basis of patients’ symptoms, tongue, and pulse (Li et al., 2012). …”
Publicado 2022
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693051“…The October 1923 award of the Nobel Prize in Physiology or Medicine to FG Banting and JJR Macleod ignored Paulescu's scientific achievements in the treatment of experimental diabetes and rewarded the extraordinary advance of insulin treatment in human diabetes. B-At the end of August 2003, a few days before the date of the celebration at the Hôtel Dieu in Paris of the scheduled program of tribute to the scientific merits of NC Paulescu and his important contribution to the discovery of the antidiabetic hormone, convened by the Romanian Academy and the International Diabetes Federation, the Wiesenthal Foundation publicly accused the Romanian scientist of being an antisemite, an act that determined the cancellation of the announced events. …”
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693052por Okoro, Catherine A., Zhao, Guixiang, Fox, Jared B., Eke, Paul I., Greenlund, Kurt J., Town, Machell“…Estimated prevalence of cancer screenings, influenza vaccination, and having ever been tested for human immunodeficiency virus also varied by state, state Medicaid expansion status, expanded geographic region, and FPL category. …”
Publicado 2017
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693053por Cuadrado-Lavín, Antonio, Olmos, José Manuel, Cifrian, José Manuel, Gimenez, Teresa, Gandarillas, Marco Antonio, García-Saiz, Mar, Rebollo, Maria Henar, Martínez-Taboada, Victor, López-Hoyos, Marcos, Fariñas, María Carmen, Crespo, Javier“…Exclusion criteria: 1) Previous infection with SARS CoV2 (positive coronavirus PCR or positive serology with SARS Cov2 negative PCR and absence of symptoms); 2) Current treatment with hydroxychloroquine or chloroquine; 3) Hypersensitivity, allergy or any contraindication for taking hydroxychloroquine, in the technical sheet; 4) Previous or current treatment with tamoxifen or raloxifene; 5) Previous eye disease, especially maculopathy; 6) Known heart failure (Grade III to IV of the New York Heart Association classification) or prolonged QTc; 7) Any type of cancer (except basal cell) in the last 5 years; 6) Refusal to give informed consent; 8) Evidence of any other unstable or clinically significant untreated immune, endocrine, hematological, gastrointestinal, neurological, neoplastic or psychiatric illness; 9) Antibodies positive for the human immunodeficiency virus; 10) Significant kidney or liver disease; 11) Pregnancy or lactation. …”
Publicado 2020
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693054por Lu, Peng-Jun, Hung, Mei-Chuan, Srivastav, Anup, Grohskopf, Lisa A., Kobayashi, Miwako, Harris, Aaron M., Dooling, Kathleen L., Markowitz, Lauri E., Rodriguez-Lainz, Alfonso, Williams, Walter W.“…REPORTING PERIOD: August 2017–June 2018 (for influenza vaccination) and January–December 2018 (for pneumococcal, herpes zoster, tetanus and diphtheria [Td]/tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis [Tdap], hepatitis A, hepatitis B, and human papillomavirus [HPV] vaccination). DESCRIPTION OF SYSTEM: The National Health Interview Survey (NHIS) is a continuous, cross-sectional national household survey of the noninstitutionalized U.S. civilian population. …”
Publicado 2021
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693055por Wang, X.W., Han, P.J., Bai, F.Y., Luo, A., Bensch, K., Meijer, M., B., Kraak, Han, D.Y., Sun, B.D., Crous, P.W., Houbraken, J.“…Chaetomiaceae comprises phenotypically diverse species, which impact biotechnology, the indoor environment and human health. Recent studies showed that most of the traditionally defined genera in Chaetomiaceae are highly polyphyletic. …”
Publicado 2022
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693056“…PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. …”
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693057“…As many of the infectious agents associated with diarrhoea are transmitted through faeces, sanitation interventions to safely contain and manage human faeces have the potential to reduce exposure and diarrhoeal disease. …”
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693058por Hektoen, Ludvig“…In this connection it may be pointed out that while there cannot very well be any question but that we are dealing only with dividing and not coalescing cells, yet if this conclusion should be disputed and found incorrect, then the only remaining alternative would be to infer that this tissue furnished a unique and striking example of the formation of plasmodial masses by fusion in human tuberculosis, a conclusion to which many pathologists would refuse to subscribe, if for no other reason than because it is not in accordance with the almost universally accepted teachings of Baumgarten and Weigert in regard to the mode of formation of the giant cells in tuberculosis. …”
Publicado 1898
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693059“…Focus group topics were developed by 4 experienced investigators, with training in biomedical informatics, cognitive psychology, human factors, and workflow analysis, based upon a knowledge of the literature. …”
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693060por Benavente-Perez, Alexandra, Nour, Ann, Ansel, Tobin, Abarr, Kathleen, Yan, Luying, Roden, Keisha, Troilo, David, Lu, Chanyi, Pan, Miaozhen, Zheng, Min, Qu, Jia, Zhou, Xiangtian, Wildsoet, Christine F., Lu, Fan, Zhou, Xiangtian, Chen, Jie, Bao, Jinhua, Hu, Liang, Wang, Qinmei, Jin, Zibing, Qu, Jia, Rucker, Frances, Britton, Stephanie, Hanowsky, Stephan, Spatcher, Molly, Kuo, Hui-Ying, Ke, Ching-Hsiu, Kuo, I-Hsin, Peng, Chien-Chun, Sun, Han-Yin, Morgan, Ian G., Guggenheim, Jeremy A., Shah, Rupal L., Williams, Cathy, Yang, Jinglei, Reinach, Peter S., Zhang, Sen, Pan, Miaozhen, Sun, Wenfeng, Liu, Bo, Li, Fen, Li, Xiaoqing, Zhao, Aihua, Chen, Tianlu, Jia, Wei, Qu, Jia, Zhou, Xiangtian, Jiang, Jun, Wu, Haoran, Lu, Fan, Tsubota, Kazuo, Ozawa, Hiroko, Torii, Hidemasa, Takamizawa, Shigemasa, Kurihara, Toshihide, Negishi, Kazuno, Graef, Klaus, Rathbun, Daniel, Schaeffel, Frank, Ghodsi, Ladan, Stell, William K., Pardue, Machelle T., Chakraborty, Ranjay, Park, Han na, Sidhu, Curran S., Iuvone, P. Michael, Collins, Michael J, Srinvasalu, Nethrajeith, McFadden, Sally A., Baird, Paul N., Iuvone, P. Michael, Artal, Pablo, Cho, Pauline, Cheung, SW, Wu, Pei-Chang, Hoang, Quan V., McFadden, Sally A., Chakraborty, Ranjay, Lee, Duk C., Landis, Erica G., Bergen, Michael A., Sidhu, Curran, Hattar, Samer, Iuvone, P. Michael, Stone, Richard A., Pardue, Machelle T., Metlapally, Ravi, Li, Ruiqin, Xu, Qinglin, Zhong, Hong, Pan, Chenglin, Lan, Weizhong, Li, Xiaoning, Chen, Ling, Yang, Zhikuan, Read, Scott A., Saw, Seang-Mei, Weng, Shi-Jun, Wu, Xiao-Hua, Qian, Kang-Wei, Li, Yun-Yun, Xu, Guo-Zhong, Huang, Furong, Zhou, Xiangtian, Qu, Jia, Yang, Xiong-Li, Zhong, Yong-Mei, Smith, Earl L, Arumugam, Baskar, Hung, Li-Fang, Ostrin, Lisa A., Trier, Klaus, Jong, Monica, Holden, Brien A., Lam, Thomas Chuen, Shan, Samantha, Zuo, Bing, McFadden, Sally A., Tse, Dennis Yan-yin, Bian, Jingfang, Li, King-Kit, Liu, Quan, To, Chi-ho, Gawne, Timothy J., Siegwart, John T., Ward, Alexander H., Norton, Thomas T., Zhou, Xiangtian, Zhang, Yan, Liu, Yue, Ho, Carol, Phan, Eileen, Hang, Abraham, Eng, Emily, Wildsoet, Christine“…Michael Iuvone O15 Response of the human choroid to defocus Michael J Collins O16 What can RNA sequencing tell us about myopic sclera? …”
Publicado 2016
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