Modeling the Differentiation of Embryonic Limb Chondroprogenitors by Cell Death and Cell Senescence in High Density Micromass Cultures and Their Regulation by FGF Signaling

por Duarte-Olivenza, Cristina, Hurle, Juan M., Montero, Juan A., Lorda-Diez, Carlos I.
Publicado 2022

Genomic Analysis of Hepatitis B Virus Reveals Antigen State and Genotype as Sources of Evolutionary Rate Variation

por Harrison, Abby, Lemey, Philippe, Hurles, Matthew, Moyes, Chris, Horn, Susanne, Pryor, Jan, Malani, Joji, Supuri, Mathias, Masta, Andrew, Teriboriki, Burentau, Toatu, Tebuka, Penny, David, Rambaut, Andrew, Shapiro, Beth
Publicado 2011

Using population data for assessing next-generation sequencing performance

por Houniet, Darren T., Rahman, Thahira J., Al Turki, Saeed, Hurles, Matthew E., Xu, Yaobo, Goodship, Judith, Keavney, Bernard, Santibanez Koref, Mauro
Publicado 2015

The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline

por Adewoye, Adeolu B., Lindsay, Sarah J., Dubrova, Yuri E., Hurles, Matthew E.
Publicado 2015

Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms

por Abyzov, Alexej, Li, Shantao, Kim, Daniel Rhee, Mohiyuddin, Marghoob, Stütz, Adrian M., Parrish, Nicholas F., Mu, Xinmeng Jasmine, Clark, Wyatt, Chen, Ken, Hurles, Matthew, Korbel, Jan O., Lam, Hugo Y. K., Lee, Charles, Gerstein, Mark B.
Publicado 2015

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery

por Rebollo-Lopez, María Jose, Lelièvre, Joël, Alvarez-Gomez, Daniel, Castro-Pichel, Julia, Martínez-Jiménez, Francisco, Papadatos, George, Kumar, Vinod, Colmenarejo, Gonzalo, Mugumbate, Grace, Hurle, Mark, Barroso, Vanessa, Young, Rob J., Martinez-Hoyos, María, González del Río, Rubén, Bates, Robert H., Lopez-Roman, Eva Maria, Mendoza-Losana, Alfonso, Brown, James R., Alvarez-Ruiz, Emilio, Marti-Renom, Marc A., Overington, John P., Cammack, Nicholas, Ballell, Lluís, Barros-Aguire, David
Publicado 2015

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

por Martin, Carol-Anne, Ahmad, Ilyas, Klingseisen, Anna, Hussain, Muhammad Sajid, Bicknell, Louise S, Leitch, Andrea, Nürnberg, Gudrun, Toliat, Mohammad Reza, Murray, Jennie E, Hunt, David, Khan, Fawad, Ali, Zafar, Tinschert, Sigrid, Ding, James, Keith, Charlotte, Harley, Margaret E, Heyn, Patricia, Müller, Rolf, Hoffmann, Ingrid, Cormier-Daire, Valérie, Dollfus, Hélène, Dupuis, Lucie, Bashamboo, Anu, McElreavey, Kenneth, Kariminejad, Ariana, Mendoza-Londono, Roberto, Moore, Anthony T, Saggar, Anand, Schlechter, Catie, Weleber, Richard, Thiele, Holger, Altmüller, Janine, Höhne, Wolfgang, Hurles, Matthew E, Noegel, Angelika Anna, Baig, Shahid Mahmood, Nürnberg, Peter, Jackson, Andrew P
Publicado 2014

Apoptosis during embryonic tissue remodeling is accompanied by cell senescence

por Lorda-Diez, Carlos I., Garcia-Riart, Beatriz, Montero, Juan A., Rodriguez-León, Joaquín, Garcia-Porrero, Juan A, Hurle, Juan M.
Publicado 2015

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

por Harley, Margaret E., Murina, Olga, Leitch, Andrea, Higgs, Martin R., Bicknell, Louise S., Yigit, Gökhan, Blackford, Andrew N., Zlatanou, Anastasia, Mackenzie, Karen J., Reddy, Kaalak, Halachev, Mihail, McGlasson, Sarah, Reijns, Martin A. M., Fluteau, Adeline, Martin, Carol-Anne, Sabbioneda, Simone, Elcioglu, Nursel H., Altmüller, Janine, Thiele, Holger, Greenhalgh, Lynn, Chessa, Luciana, Maghnie, Mohamad, Salim, Mahmoud, Bober, Michael B., Nürnberg, Peter, Jackson, Stephen P., Hurles, Matthew E., Wollnik, Bernd, Stewart, Grant S., Jackson, Andrew P.
Publicado 2015

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues

por Kumar, Vinod, Sanseau, Philippe, Simola, Daniel F., Hurle, Mark R., Agarwal, Pankaj
Publicado 2016

Detection of structural mosaicism from targeted and whole-genome sequencing data

por King, Daniel A., Sifrim, Alejandro, Fitzgerald, Tomas W., Rahbari, Raheleh, Hobson, Emma, Homfray, Tessa, Mansour, Sahar, Mehta, Sarju G., Shehla, Mohammed, Tomkins, Susan E., Vasudevan, Pradeep C., Hurles, Matthew E.
Publicado 2017

Histone Epigenetic Signatures in Embryonic Limb Interdigital Cells Fated to Die

por Sanchez-Fernandez, Cristina, Lorda-Diez, Carlos I., Duarte-Olivenza, Cristina, Hurle, Juan M., Montero, Juan A.
Publicado 2021

Osteogenic lithium-doped brushite cements for bone regeneration

por Hurle, K., Maia, F.R., Ribeiro, V.P., Pina, S., Oliveira, J.M., Goetz-Neunhoeffer, F., Reis, R.L.
Publicado 2021

Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation

por Aburto, M R, Sánchez-Calderón, H, Hurlé, J M, Varela-Nieto, I, Magariños, M
Publicado 2012

Birth-and-Death of KLK3 and KLK2 in Primates: Evolution Driven by Reproductive Biology

por Marques, Patrícia Isabel, Bernardino, Rui, Fernandes, Teresa, Green, Eric D., Hurle, Belen, Quesada, Victor, Seixas, Susana
Publicado 2012

Expression and Functional Study of Extracellular BMP Antagonists during the Morphogenesis of the Digits and Their Associated Connective Tissues

por Lorda-Diez, Carlos I., Montero, Juan A., Rodriguez-Leon, Joaquin, Garcia-Porrero, Juan A., Hurle, Juan M.
Publicado 2013

NDUFA4 Mutations Underlie Dysfunction of a Cytochrome c Oxidase Subunit Linked to Human Neurological Disease

por Pitceathly, Robert D.S., Rahman, Shamima, Wedatilake, Yehani, Polke, James M., Cirak, Sebahattin, Foley, A. Reghan, Sailer, Anna, Hurles, Matthew E., Stalker, Jim, Hargreaves, Iain, Woodward, Cathy E., Sweeney, Mary G., Muntoni, Francesco, Houlden, Henry, Taanman, Jan-Willem, Hanna, Michael G.
Publicado 2013

Potential research participants support the return of raw sequence data

por Middleton, Anna, Wright, Caroline F, Morley, Katherine I, Bragin, Eugene, Firth, Helen V, Hurles, Matthew E, Parker, Michael
Publicado 2015

Facilitating Collaboration in Rare Genetic Disorders Through Effective Matchmaking in DECIPHER

por Chatzimichali, Eleni A., Brent, Simon, Hutton, Benjamin, Perrett, Daniel, Wright, Caroline F., Bevan, Andrew P., Hurles, Matthew E., Firth, Helen V., Swaminathan, Ganesh J.
Publicado 2015

The NHGRI Short Course in Genomics: Energizing genetics and genomics education in classrooms through direct engagement between educators and scientists

por Robbins, Sarah M., Daulton, Christina R., Hurle, Belen, Easter, Carla
Publicado 2020