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221“…Congenital glycosylation defect type Ib is due to deficiency in phosphomannose isomerase which converts fructose-6-phosphate into mannose-6-phosphate. …”
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222por Fan, Fei, Tang, Ying, Dai, Hengfen, Cao, Yang, Sun, Pei, Chen, Yu, Chen, Aiqin, Lin, Chun“…BACKGROUND: Irritable bowel syndrome (IBS) is a common functional disease characterized by chronic abdominal pain and changes in bowel movements. …”
Publicado 2020
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223por Agnello, Melissa, Carroll, Lauren N, Imam, Nabeel, Pino, Rodolfo, Palmer, Christina, Varas, Ignacio, Greene, Claire, Hitschfeld, Maureen, Gupta, Sarah, Almonacid, Daniel E, Hoaglin, Michael C“…OBJECTIVE: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is difficult to diagnose and treat due to its inherent heterogeneity and unclear aetiology. …”
Publicado 2020
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224por Vork, Lisa, Mujagic, Zlatan, Drukker, Marjan, Keszthelyi, Daniel, Conchillo, José M., Hesselink, Martine A. M., van Os, Jim, Masclee, Ad A. M., Leue, Carsten, Kruimel, Joanna W.“…BACKGROUND: Confirming treatment response in clinical trials for irritable bowel syndrome (IBS) is challenging, due to the lack of biomarkers and limitations of the currently available symptom assessment tools. …”
Publicado 2018
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225por Zhou, Li‐Yu, Han, Feng, Qi, Shi‐Bin, Ma, Jin‐Jin, Ma, Yan‐Xia, Xie, Ji‐Le, Zhang, Hong‐Cheng, Fu, Xin‐Ya, Chen, Jian‐Quan, Li, Bin, Yang, Hui‐Lin, Zhou, Feng, Saijilafu“…In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4‐positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4‐positive neuronal axon growth. …”
Publicado 2020
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226por da Silva, Sivoneide Maria, Ramos, Bárbara de Azevedo, Lima, Ana Vitória Araújo, de Sá, Rafael Artur Cavalcanti Queiroz, Lima, Jailton Lobo da Costa, Maciel, Maria Amélia Vieira, Paiva, Patrícia Maria Guedes, da Silva, Márcia Vanusa, Correia, Maria Tereza dos Santos, de Oliveira, Maria Betânia Melo“…INTRODUCTION: The aac(6’)-Ib-cr and bla (KPC) genes are spreading among Enterobacteriaceae species, including Providencia stuartii, in some countries of world. …”
Publicado 2020
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227por Wang, Yingchun, Chen, Wenchun, Zhang, Wei, Lee-Sundlov, Melissa M., Casari, Caterina, Berndt, Michael C., Lanza, Francois, Bergmeier, Wolfgang, Hoffmeister, Karin M., Zhang, X. Frank, Li, Renhao“…The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the extracellular domain of GPIbα, but neither von Willebrand factor nor ADAM17 (a disintegrin and metalloprotease 17), is required for platelet clearance induced by intravenous injection of neuraminidase. …”
Publicado 2020
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228por Chen, Jenny Ling-Yu, Huang, Chao-Yuan, Huang, Yu-Sen, Hsu, Che-Yu, Lan, Keng-Hsueh, Shih, I-Lun, Cheng, Wen-Fang, Chen, Chi-An, Sheu, Bor-Ching, Kuo, Sung-Hsin“…However, the optimal adjuvant treatment for stage IB endometrial cancer is not well-defined. We aimed to study the benefit of modern adjuvant radiotherapy for women with stage IB endometrial cancer. …”
Publicado 2021
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229por Halligan, Rebecca, White, Fiona J., Schwahn, Bernd, Stepien, Karolina M., Kamarus Jaman, Nazreen, McSweeney, Mel, Kitchen, Steve, Gribben, Joanna, Dawson, Charlotte, Lewis, Katherine, Cregeen, David, Mundy, Helen, Santra, Saikat“…Glycogen storage disease type Ib (GSDIb) is characterized by hepatomegaly and fasting hypoglycaemia as well as neutropaenia and recurrent infections. …”
Publicado 2021
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230“…Secondary hyperparathyroidism (sHPT) was a common complication in maintenance hemodialysis patients with CRF. Nuclear factor IB (NFIB) was a newly found tumor suppressor gene in various cancers. …”
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231“…BACKGROUND: Visceral hypersensitivity in irritable bowel syndrome (IBS) is still poorly understood, despite that chronic abdominal pain is the most common symptoms in IBS patients. …”
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232“…We report here the nearly complete genome sequences of two human BK polyomavirus (BKV) strains recovered from two Vietnamese renal allograft recipients and belonging to subtypes IVc1 (strain VN_PBK185) and Ib1 (strain VN_PBK212). The genome sequences of VN_PBK185 and VN_PBK212 were highly similar (99.9% nucleotide identity) to the reference BKV strains VNM-1 and VNM-9, respectively.…”
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233por Abreu, Damien, Stone, Stephen I., Pearson, Toni S., Bucelli, Robert C., Simpson, Ashley N., Hurst, Stacy, Brown, Cris M., Kries, Kelly, Onwumere, Chinyere, Gu, Hongjie, Hoekel, James, Tychsen, Lawrence, Van Stavern, Gregory P., White, Neil H., Marshall, Bess A., Hershey, Tamara, Urano, Fumihiko“…METHODS: Based on results from preclinical studies on dantrolene sodium and ongoing longitudinal studies, we assembled what we believe is the first-ever clinical trial in pediatric and adult Wolfram syndrome patients with an open-label phase Ib/IIa trial design. The primary objective was to assess the safety and tolerability of dantrolene sodium in adult and pediatric Wolfram syndrome patients. …”
Publicado 2021
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234por De Meulenaere, Astrid, Vermassen, Tijl, Creytens, David, De Keukeleire, Stijn, Delahaye, Tim, Deron, Philippe, Duprez, Fréderic, Fung, Samson, Pauwels, Patrick, Ferdinande, Liesbeth, Rottey, SylvieEnlace del recurso
Publicado 2021
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235por Rahma, Osama E, Tyan, Kevin, Giobbie-Hurder, Anita, Brohl, Andrew S, Bedard, Philippe L, Renouf, Daniel J, Sharon, Elad, Streicher, Howard, Hathaway, Emma, Cunningham, Rachel, Manos, Michael, Severgnini, Mariano, Rodig, Scott, Stephen Hodi, F“…We report results from a phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors. …”
Publicado 2022
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236por Zhai, Wenyu, Gong, Li, Zheng, Yuzhen, Yan, Qihang, Lai, Renchun, Liang, Dachuan, Wong, Wingshing, Dai, Shuqin, Wang, Junye“…However, studies investigating its value in the related stage IB–IIA lung adenocarcinoma (LUAD) remains lacking. …”
Publicado 2022
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237por Chi, Ping, Qin, Li-Xuan, Camacho, Niedzica, Kelly, Ciara M., D'Angelo, Sandra P., Dickson, Mark A., Gounder, Mrinal M., Keohan, Mary L., Movva, Sujana, Nacev, Benjamin A., Rosenbaum, Evan, Thornton, Katherine A., Crago, Aimee M., Francis, Jasmine H., Martindale, Moriah, Phelan, Haley T., Biniakewitz, Matthew D., Lee, Cindy J., Singer, Samuel, Hwang, Sinchun, Berger, Michael F., Chen, Yu, Antonescu, Cristina R., Tap, William D.“…PURPOSE: This phase Ib trial was designed to evaluate the safety and early efficacy signal of the combination of imatinib and binimetinib in patients with imatinib-resistant advanced gastrointestinal stromal tumors (GISTs). …”
Publicado 2022
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238“…Further, we examine how IBS is related to these SRH measures. METHODS: The sample included 5288 Norwegian twins aged 40–80, of whom 575 (10.9%) suffer from IBS. …”
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239por Nagasawa, Saya, Kasahara, Makiko, Aoki, Yuji, Kusunoki, Soshi, Sugimori, Yayoi, Matsuoka, Shozo, Ogura, Kanako, Ogishima, DaikiEnlace del recurso
Publicado 2021
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240por Schuler, Martin, Zimmer, Lisa, Kim, Kevin B., Sosman, Jeffrey A., Ascierto, Paolo A., Postow, Michael A., De Vos, Filip Y.F.L., van Herpen, Carla M.L., Carlino, Matteo S., Johnson, Douglas B., Berking, Carola, Reddy, Micaela B., Harney, Allison S., Berlin, Jordan D., Amaria, Rodabe N.“…PATIENTS AND METHODS: This is a phase Ib/II, open-label study of ribociclib + binimetinib in patients with NRAS-mutant melanoma (NCT01781572). …”
Publicado 2022
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