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382por Zhang, Pei, Duan, Jianchun, Bai, Hua, Wang, Zhijie, Gao, Shugeng, Tan, Fengwei, Gao, Yushun, Wang, Xin, Wan, Rui, Xu, Jiachen, He, Xiran, Feng, Xiaoshuang, Yu, Ruofei, Sun, Jing, Zhao, Zhe, Fei, Kailun, Li, Ni, He, Jie, Wang, Jie“…BACKGROUND: The role of adjuvant chemotherapy (ACT) for patients with stage IB–IIA non‐small cell lung cancer (NSCLC) according to the eighth edition of the AJCC TNM staging system remains controversial. …”
Publicado 2020
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383por Küsters, Kira, Pohl, Martina, Krauss, Ulrich, Ölçücü, Gizem, Albert, Sandor, Jaeger, Karl-Erich, Wiechert, Wolfgang, Oldiges, Marco“…Comprehensive morphology and enzymatic activity analyses were performed for the ten EcLDCc-CatIB variants and a wild type EcLDCc control to identify the CatIB variant with the highest activity for the decarboxylation of l-lysine to 1,5-diaminopentane. …”
Publicado 2021
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384por Cibert-Goton, Vincent, Lam, Ching, Lingaya, Melanie, Falcone, Yirga, Wood, John N., Bulmer, David C., Spiller, Robin“…INTRODUCTION: Despite heterogeneity, an increased prevalence of psychological comorbidity and an altered pronociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome (IBS). Our aim was to study these phenomena by comparing gut-related symptoms, psychological scores, and biopsy samples generated from a detailed diarrhea-predominant IBS patient (IBS-D) cohort before their entry into a previously reported clinical trial. …”
Publicado 2021
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385por Zhang, Baojian, Ren, Maomao, Xiong, Yang, Li, Haonan, Wu, Yong, Fu, Ying, Zhangsun, Dongting, Dong, Shuai, Luo, Sulan“…α-Conotoxin TxIB, a selective antagonist of α6/α3β2β3 nicotinic acetylcholine receptor, could be a potential therapeutic agent for addiction and Parkinson’s disease. …”
Publicado 2021
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386por Du, Caiqi, Li, Zhuoguang, Wei, Hong, Zhang, Min, Hu, Minghui, Zhang, Cai, Luo, Xiaoping, Liang, Yan“…BACKGROUND: To investigate the clinical and genetic characteristics of patients with glycogen storage disease type Ib (GSD Ib). CASE PRESENTATION: This report retrospectively analyzed the clinical data of 3 patients with GSD Ib admitted into our hospital, and summarized their onset characteristics, clinical manifestations, related examinations and treatment as well as mutational spectrum. …”
Publicado 2021
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387por Pinato, David J., Cortellini, Alessio, Sukumaran, Ajithkumar, Cole, Tom, Pai, Madhava, Habib, Nagy, Spalding, Duncan, Sodergren, Mikael H., Martinez, Maria, Dhillon, Tony, Tait, Paul, Thomas, Robert, Ward, Caroline, Kocher, Hemant, Yip, Vincent, Slater, Sarah, Sharma, Rohini“…Here, we describe the design and rationale of PRIME-HCC, a two-part, multi-centre, phase Ib study to assess safety and bioactivity of the nivolumab/ipilimumab combination prior to LR in early-stage HCC. …”
Publicado 2021
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388por Khurshed, Mohammed, Molenaar, Remco J., van Linde, Myra E., Mathôt, Ron A., Struys, Eduard A., van Wezel, Tom, van Noorden, Cornelis J. F., Klümpen, Heinz-Josef, Bovée, Judith V. M. G., Wilmink, Johanna W.“…Conclusion: Treatment of advanced IDH1-mutated solid tumors with metformin and chloroquine was well tolerated but did not induce a clinical response in this phase Ib clinical trial.…”
Publicado 2021
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389por Schneider, Marcel A., Linecker, Michael, Fritsch, Ralph, Muehlematter, Urs J., Stocker, Daniel, Pestalozzi, Bernhard, Samaras, Panagiotis, Jetter, Alexander, Kron, Philipp, Petrowsky, Henrik, Nicolau, Claude, Lehn, Jean-Marie, Humar, Bostjan, Graf, Rolf, Clavien, Pierre-Alain, Limani, Perparim“…Here, we report the results of an unrandomized, open-labeled, 3 + 3 dose-escalation phase Ib study (NCT02528526) including 28 patients with advanced primary hepatopancreatobiliary malignancies and liver metastases of colorectal cancer receiving nine 8h-infusions of ITPP over three weeks across eight dose levels (1'866-14'500 mg/m(2)/dose), followed by standard chemotherapy. …”
Publicado 2021
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390“…Glycogen storage disease (GSD) Ib is a rare genetic metabolic disorder caused by gene mutation in the glucose 6-phosphate transport gene SLC37A4 (OMIM# 602671). …”
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391por Wang, Peng, Du, Chao, Chen, Fei-Xue, Li, Chang-Qing, Yu, Yan-Bo, Han, Ting, Akhtar, Suhail, Zuo, Xiu-Li, Tan, Xiao-Di, Li, Yan-QingEnlace del recurso
Publicado 2021
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392por Strati, Paolo, de Vos, Sven, Ruan, Jia, Maddocks, Kami J., Flowers, Christopher R., Rule, Simon, Patel, Priti, Xu, Yan, Wei, Helen, Frigault, Melanie M., Calvo, Roser, Dyer, Martin J.S.Enlace del recurso
Publicado 2021
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393“…Functional gut symptoms, including irritable bowel syndrome (IBS), is one cause of persistent symptoms in CD patients. …”
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394por van Heerden, Peter Vernon, Abutbul, Avraham, Sviri, Sigal, Zlotnick, Eitan, Nama, Ahmad, Zimro, Sebastian, el-Amore, Raja, Shabat, Yehudit, Reicher, Barak, Falah, Batla, Mevorach, Dror“…The primary aim of this phase IB study was to determine the safety profile of Allocetra™-OTS (early apoptotic cell) infusion in subjects presenting to the emergency room with sepsis. …”
Publicado 2021
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395por Hawkes, Eliza A., Phillips, Tycel, Budde, Lihua Elizabeth, Santoro, Armando, Saba, Nakhle S., Roncolato, Fernando, Gregory, Gareth P., Verhoef, Gregor, Offner, Fritz, Quero, Cristina, Radford, John, Giannopoulos, Krzysztof, Stevens, Don, Thall, Aron, Huang, Bo, Laird, A. Douglas, Sandner, Robin, Ansell, Stephen M.“…METHODS: This was a multicenter, randomized, open-label, parallel-arm study with a phase Ib and a phase III component. Reported here are the results from the phase Ib study, wherein 29 adult patients with DLBCL were randomized 1:1:1 to receive avelumab in combination with utomilumab (an immunoglobulin G2 4-1BB agonist) and rituximab (arm A), avelumab in combination with utomilumab and azacitidine (arm B), or avelumab in combination with bendamustine and rituximab (arm C). …”
Publicado 2021
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396por Saito, Takuro, Kurose, Koji, Kojima, Takashi, Funakoshi, Takeru, Sato, Eiichi, Nishikawa, Hiroyoshi, Nakajima, Jun, Seto, Yasuyuki, Kakimi, Kazuhiro, Iida, Shinsuke, Doki, Yuichiro, Oka, Mikio, Ueda, Ryuzo, Wada, Hisashi“…KW-0761 (Mogamulizumab) is a humanized anti-CCR4 monoclonal antibody that could eliminate activated Tregs with high immunosuppressive activity that express CCR4. In this phase Ib trial, KW-0761 was used as a cancer immunotherapeutic reagent to deplete Tregs in patients with advanced or recurrent solid CCR4-negative tumors. …”
Publicado 2021
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397por Gaughan, Erin, Quinn, Tom, Bruce, Annya, Antonelli, Jean, Young, Vikki, Mair, Joanne, Akram, Ahsan, Hirani, Nik, Koch, Oliver, Mackintosh, Claire, Norrie, John, Dear, James W, Dhaliwal, KevinEnlace del recurso
Publicado 2021
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398por Jeong, Soo Young, Park, Byung Kwan, Choi, Chel Hun, Lee, Yoo-Young, Kim, Tae-Joong, Lee, Jeong-Won, Kim, Byoungi-Gie“…SIMPLE SUMMARY: 3T MRI can estimate more precisely the tumor volume of early cervical cancer than physical examination. Women with IB1 cervical cancer, which is invisible on 3T MRI, have no parametrial invasion so that parametrectomy can be skipped or minimized. …”
Publicado 2022
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399“…The primary outcome was severity of IBS symptoms (IBS-Symptom Severity Score, IBS-SSS). …”
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400“…OBJECTIVES: To assess the risk factors of lymph node metastasis (LNM) in patients with FIGO stage (2009) IB1 cervical cancer (CC). METHODS: Patients with FIGO stage IB1 CC who underwent radical resection between 2012 and 2018 were recruited. …”
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