“…PATIENTS AND METHODS: This phase Ib study evaluated atezolizumab + radium-223 in men with mCRPC and bone and lymph node and/or visceral metastases that progressed after androgen pathway inhibitor treatment. …”
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“…The effect of various factors on complex formation between the monensinate A anion and group IA and IB metal ions was assessed. Competition between Na(+) taken as a reference and monovalent metal cations was estimated using the Gibbs free energy for substituting the ligand-bound Na(+) with its rival ions in the process [M(+)-solution] + [Mon(−)Na(+)] → [Mon(−)M(+)] + [Na(+)-solution] (M(+) = Li(+), K(+), Rb(+), Cs(+), Cu(+), Ag(+) and Au(+)). …”
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“…BACKGROUND: Glycogen storage disease type Ib (GSD Ib) is a severe disorder of carbohydrate metabolism due to bi-allelic variants in SLC37A4. …”
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“…Parsaclisib, a potent, selective, next‐generation PI3Kδ inhibitor, has shown clinical benefit in patients with relapsed or refractory B‐cell lymphoma. We undertook a phase Ib study (CITADEL‐111) evaluating safety, pharmacokinetics, and efficacy of parsaclisib in Japanese patients with relapsed or refractory B‐cell malignancies. …”
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“…The primary aim of the mind and yoga for IBS randomised controlled trial is to determine the effects of an 8-week virtual meditation and yoga intervention on IBS symptom severity compared with an advice-only active control group. …”
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“…BACKGROUND: Subcutaneous tocilizumab (TCZ SC) is approved globally for giant cell arteritis (GCA). This phase Ib study investigated the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of intravenous (IV) TCZ 6 and 7 mg/kg in patients with GCA. …”
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“…OBJECTIVES: To investigate the relationships and differences in lifestyle factors including anxiety level, physical activity, diet, and sleep on breath hydrogen and gastrointestinal symptoms in individuals with and without IBS after consumption of gluten and Inulin. METHODS: A double-blind, randomized, controlled crossover design was conducted with 24 non-IBS and 14 IBS participants. …”
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“…INTRODUCTION: Recently published case reports suggest the benefit of empagliflozin use in subjects with glycogen storage disease Ib (GSD Ib). METHODS: We present the clinical and laboratory data of 2 adult brothers with GSD Ib treated with empagliflozin for 12 months. …”
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“…We evaluated safety, tolerability, and the pharmacodynamic interaction between vericiguat and nitroglycerin, coadministered in patients with CCSs. In this phase Ib, double‐blind, randomized, multicenter study, 36 patients with CCSs received either vericiguat 2.5 mg (up‐titrated every 2 weeks to 5 mg and 10 mg) or placebo. …”
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“…Agrobacterium rhizogenes-mediated in vivo transgenic technology, non-invasive micro-measuring technology (NMT) and Na(+) fluorescence imaging technology were then combined to quickly study the potential function of IbIPUT1 in salt tolerance. The data showed that IbIPUT1 was involved in the regulation of root cell Na(+) balance, and the overexpression of IbIPUT1 could not promote sweet potato root cell Na(+) efflux under salt stress, but it could significantly inhibit the Na(+) absorption of root cells, thereby reducing the accumulation of Na(+) in root cells under salt stress. …”
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“…OBJECTIVE: Irritable bowel syndrome (IBS) is a chronic disease leading to abdominal pain that is often related to psychological distress. …”
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“…METHODS: A total of 149 patients with IB2 and IIA2 SCC who underwent pretreatment MRI and DWI scan were included. …”
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“…Particle-mediated transient transformation of onion epidermal cells showed IbMYB48 is localized in the nucleus. Transactivation activity assay in yeast cells revealed that IbMYB48 has transactivation activity, and its active domain is located in the carboxyl (C)-terminal region. …”
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“…Our objective was to evaluate the effects of a multistrain probiotic on IBS symptoms, gut permeability and gut microbiota in patients with diarrhoea-predominant IBS (IBS-D). …”
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“…APPROACH AND RESULTS: In this pooled analysis of two single‐center, phase Ib clinical trials (TQB2450‐Ib‐05 and TQB2450‐Ib‐08 trials), 66 patients with advanced BTCs who had progressed or declined or were ineligible for first‐line chemotherapy were included. …”
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“…This is the phase Ib part of the phase I/II CAMILLA trial evaluating cabozantinib plus durvalumab in advanced chemo-refractory proficient mismatch repair or microsatellite stable (pMMR/MSS) gastrointestinal malignancies including gastric/gastroesophageal junction/esophageal (G/GEJ/E) adenocarcinoma, colorectal cancer (CRC), and hepatocellular carcinoma (HCC). …”
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Materias: “…Management Costs of IBS…”
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