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503por Tsang, Erica S., Aggarwal, Rahul R., Dhawan, Mallika S., Bergsland, Emily K., Alvarez, Edwin A., Calabrese, Susan, Pacaud, Romain, Garcia, Jose, Fattah, Delaire, Thomas, Scott, Grabowsky, Jennifer, Moasser, Mark M., Munster, Pamela N.“…The PI3K pathway may be a potential mechanism to overcome cisplatin resistance. We conducted a phase Ib trial of alpelisib and cisplatin for patients with solid tumor malignancies with planned dose expansion in HPV-associated tumors. …”
Publicado 2022
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504por Sun, Zhangyin, Wang, Xuejiao, Feng, Shangsheng, Xie, Chaoju, Xing, Yu, Guo, Liang, Zhao, Jingyu, Ji, Changchun“…Irritable bowel syndrome (IBS) is a common digestive disorder observed in clinics. …”
Publicado 2023
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505por Simeone, Paola, Liani, Rossella, Tripaldi, Romina, Ciotti, Sonia, Recchiuti, Antonio, Abbonante, Vittorio, Porro, Benedetta, Del Boccio, Piero, di Castelnuovo, Augusto, Lanuti, Paola, Camera, Marina, Pieragostino, Damiana, Lee-Sundlov, Melissa, Luongo, Myriam, Auciello, Raffaella, Bologna, Giuseppina, Cufaro, Maria Concetta, Tremoli, Elena, Hoffmeister, Karin M., Cipollone, Francesco, Balduini, Alessandra, Santilli, Francesca“…Here we show that reduced PLT glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin (TPO) production and higher rates of newly formed PLT, escaping aspirin inhibition over 24 hours. …”
Publicado 2022
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506por Russo, Francesco, Riezzo, Giuseppe, Linsalata, Michele, Orlando, Antonella, Tutino, Valeria, Prospero, Laura, D'Attoma, Benedetta, Giannelli, GianluigiEnlace del recurso
Publicado 2023
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507“…OBJECTIVE: To evaluate association of preoperative conization with recurrences after laparoscopic radical hysterectomy (LRH) for FIGO 2018 stage IB1 cervical cancer. METHODS: This is a retrospective single-center study. …”
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508“…BACKGROUND: This study aimed to develop a novel predictive nomogram to identify specific stage IB non-small cell lung cancer (NSCLC) populations who could benefit from adjuvant chemotherapy (ACT). …”
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509por Du, Liqing, Zhang, Zhaozhou, Zhai, Lixiang, Xu, Shujun, Yang, Wei, Huang, Chunhua, Lin, Chengyuan, Zhong, Linda L. D., Bian, Zhaoxiang, Zhao, Ling“…BACKGROUND: Dysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel syndrome (IBS-D). Traditional Chinese Medicine (TCM), instructed by pattern differentiation, is effective in treating IBS-D, in which liver depression and spleen deficiency (LDSD) is the most prevalent pattern. …”
Publicado 2023
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510por Nadal, Ernest, Saleh, Mansoor, Aix, Santiago Ponce, Ochoa-de-Olza, Maria, Patel, Sandip Pravin, Antonia, Scott, Zhao, Yumin, Gueorguieva, Ivelina, Man, Michael, Estrem, Shawn T., Liu, Jiangang, Avsar, Emin, Lin, Wen Hong, Benhadji, Karim A., Gandhi, Leena, Guba, Susan C., Diaz, Inmaculada Ales“…BACKGROUND: In this phase Ib/II open-label study, tumor immune suppression was targeted in patients with advanced refractory solid tumors and patients with recurrent/refractory non-small cell lung cancer (NSCLC) using galunisertib with nivolumab. …”
Publicado 2023
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511por Ghosh, Subhajit, Johanns, Tanner M, Chheda, Milan G, Liu, Eric, Butt, Omar, Abraham, Christopher, Badiyan, Shahed, Huang, Yi, DeNardo, David, Kim, Albert H, Hallahan, Dennis, Thotala, Dinesh, Huang, Jiayi“…The primary objective of this pilot phase Ib study was to validate the on-target effect of tadalafil on inhibiting MDSCs in peripheral blood and its safety when combined with chemoradiotherapy in GBM patients. …”
Publicado 2023
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512por Macaulay, Valentine M., Lord, Simon, Hussain, Syed, Maroto, José Pablo, Jones, Robert Hugh, Climent, Miguel Ángel, Cook, Natalie, Lin, Chia-Chi, Wang, Shian-Shiang, Bianchini, Diletta, Bailey, Mark, Schlieker, Laura, Bogenrieder, Thomas, de Bono, Johann“…Primary endpoints in the Phase Ib escalation, Phase Ib expansion and Phase II parts were maximum tolerated dose (MTD), prostate-specific antigen response and investigator-assessed progression-free survival (PFS), respectively. …”
Publicado 2023
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513“…BACKGROUND: The purpose of this study was to investigate the role of preoperative lymphocytes, albumin, neutrophils, and LANR in the prognosis of patients with stage IB-IIA cervical cancer (CC). METHODS: We made a retrospective analysis of the clinical information and related materials of 202 patients with stage IB-IIA primary cervical cancer who had undergone a radical hysterectomy in the Department of Gynecology at the Affiliated Hospital of Jiangnan University between January 2017 and December 2018. …”
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514por Olyaiee, Alireza, Yadegar, Abbas, Mirsamadi, Elnaz Sadat, Sadeghi, Amir, Mirjalali, Hamed“…Irritable bowel syndrome (IBS) is a prevalent gastrointestinal (GI) tract disorder. …”
Publicado 2023
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515por Asselbergs, Folkert W, Moore, Jason H, van den Berg, Maarten P, Rimm, Eric B, de Boer, Rudolf A, Dullaart, Robin P, Navis, Gerjan, van Gilst, Wiek H“…Using the MDR method, the best genotype-phenotype models included the combination of micro- or macroalbuminuria and CETP TaqIB polymorphism, CRP >3 mg/L and CETP TaqIB polymorphism, renal dysfunction and the CETP TaqIB polymorphism, and ischemic heart disease and CETP TaqIB polymorphism (1000 fold permutation testing, P < 0.05). …”
Publicado 2006
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516por Yan, Jingbo, Parekh, Vrajesh V., Mendez-Fernandez, Yanice, Olivares-Villagómez, Danyvid, Dragovic, Srdjan, Hill, Timothy, Roopenian, Derry C., Joyce, Sebastian, Van Kaer, Luc“…Cell surface expression of the class Ia molecules H-2K(b) and H-2D(b) and of the class Ib molecule Qa-2 was significantly reduced in these animals. …”
Publicado 2006
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517Publicado 1994“…Unlike the highly polymorphic major histocompatibility complex (MHC) class Ia molecules, which present a wide variety of peptides to T cells, it is generally assumed that the nonpolymorphic MHC class Ib molecules may have evolved to function as highly specialized receptors for the presentation of structurally unique peptides. …”
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518por Simon, Daniel I., Chen, Zhiping, Xu, Hui, Li, Chester Q., Dong, Jing-fei, McIntire, Larry V., Ballantyne, Christie M., Zhang, Li, Furman, Mark I., Berndt, Michael C., López, José A.“…Here, we identify the platelet counterreceptor as glycoprotein (GP) Ibα, a component of the GP Ib-IX-V complex, the platelet von Willebrand factor (vWf) receptor. …”
Publicado 2000
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520por Punt, C. J., Voest, E. E., Tueni, E., Van Oosterom, A. T., Backx, A., De Mulder, P. H., Hecquet, B., Lucas, C., Gerard, B., Bleiberg, H.Enlace del recurso
Publicado 1997
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