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  1. 4161
    “…METHODS: We present a framework for assessing the appropriateness of extrapolation using trastuzumab, an anti-HER2 antibody, for HER2-amplified tumors where trastuzumab use would be off-label as an illustrative example. RESULTS: The following should be considered for the tumor type where trastuzumab would be off-label: (a) reliability of the NGS assay for detecting HER2 amplification; (b) criteria for defining HER2 positivity; (c) strength of evidence supporting the actionability of HER2 amplification and trastuzumab; (d) whether better clinical outcomes with trastuzumab are due to a more favorable natural history rather than trastuzumab effect; (e) signals of trastuzumab activity and whether it translates to clinically meaningful benefit; (f) whether the safety profile of trastuzumab differs from established indications; and (g) discussion points for shared decision making (SDM) to facilitate informed consent. …”
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    Next-generation sequencing, should I use anti-HER2 therapy for HER2-amplified tumors off-label? Illustrating an extrapolation framework
  2. 4162
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    Calcium pyrophosphate dihydrate crystal deposition disease and retro-odontoid pseudotumor rupture managed via posterior occipital cervical instrumented fusion: illustrative case
  3. 4163
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    Use of transcarotid artery revascularization for mechanical thrombectomy and treatment of symptomatic high-grade carotid artery stenosis associated with free-floating thrombus: illustrative case
  4. 4164
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    Through-and-through stab wound of the cervical spinal canal with retained weapon but no neurological repercussions: an exceptionally rare injury and the case for direct withdrawal. Illustrative case
  5. 4165
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    Intracranial hypotension due to ventral thoracic dural tear secondary to osteophyte complex: resolution after transdural thoracic microdiscectomy with dural repair. Illustrative case
  6. 4166
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    Concomitant central venous sinus thrombosis and subdural hematoma in acute promyelocytic leukemia: middle meningeal artery embolization enables safe anticoagulation. Illustrative case
  7. 4167
    por Santos, Madalena S.
    Publicado 2020
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    An illustration of how harmful the degree of freedom of the researcher is using the article entitled “Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents” as an example
  8. 4168
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    Successful shrinkage of anterior communicating artery aneurysm after ACA–ACA bypass with interposed occipital artery graft in pediatric moyamoya disease: illustrative case
  9. 4169
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    JNK pathway‐associated phosphatase illustrates low expression and negative correlations with inflammation, disease activity, and T‐helper 17 cells in inflammatory bowel disease children
  10. 4170
    Publicado 1888
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    An Illustrated Encyclopœdic Medical Dictionary: Being a Dictionary of the Technical Terms Used by Writers on Medicine and the Collateral Sciences, in the Latin, English, French and German Languages
  11. 4171
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    PMMA Cranioplasty Making by Using Оpen-Source CAD Software, PLA Printers, and Silicone Rubber Molds: Technical Note with Two Illustrative Cases
  12. 4172
    Publicado 1891
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    An Illustrated Encyclopedic Medical Dictionary: Being a Dictionary of the Technical Terms Used by Writers on Medicine and the Collateral Sciences, in the Latin, English, French and German Languages
  13. 4173
    “…The effectiveness of the proposed methodology is revealed in an illustrative case study based on the analysis of the GPS data of Taxicabs recorded during nights over a one-year-long period in Budapest.…”
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    Goal-oriented possibilistic fuzzy C-Medoid clustering of human mobility patterns—Illustrative application for the Taxicab trips-based enrichment of public transport services
  14. 4174
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    Malignant transformation of a cerebral dermoid cyst into a squamous cell carcinoma with malignant intraperitoneal spreading along a ventriculoperitoneal shunt: illustrative case
  15. 4175
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    A multi-reference poly-conformational method for in silico design, optimization, and repositioning of pharmaceutical compounds illustrated for selected SARS-CoV-2 ligands
  16. 4176
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    Development of a sigmoid sinus dural arteriovenous fistula secondary to sigmoid sinus thrombosis after resection of a foramen magnum meningioma: illustrative case
  17. 4177
    Publicado 1891
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    A Compend of Anatomy and Physiology: Illustrated by the New Model Anatomical Manikin, Including a Key, a Glossary of Medical Terms, and Incidental Notes of Pathology
  18. 4178
    por Upham, J. Baxter
    Publicado 1863
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    Cases Illustrative of the So-called “Congestive Fever,” or Cerebro-Spinal Affection: Which Has Recently Appeared in the Camps in and around the Town of Newbern, N. C.
  19. 4179
    por Hou, Simeng, Xiao, Yuanyuan, Li, Yibin
    Publicado 2022
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    Spontaneous Retinal Reperfusion of Capillary Nonperfusion Areas in Diabetic Retinopathy: A Comparative Angiographic Illustration by Fluorescence Fundus Angiography and Optic Coherence Tomography Angiography
  20. 4180
    Publicado 1847
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    Chemistry of the Four Seasons—Spring, Summer, Autumn, and Winter: An Essay Principally Concerning Natural Phenomena, Admitting of Interpretation by Chemical Science, and Illustrating Passages of Scripture
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