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  1. 86681
    “…Qualitative findings illustrated the stress of doing postgraduate training with inadequate supervision, lack of ring-fenced training time and pressures on personal and family life. …”
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    Factors influencing trainee doctor emigration in a high income country: a mixed methods study
  2. 86682
    “…Our discovery of a novel H3K9me3–H3K36me2/3 bivalent chromatin state illustrates the power of this approach, and it will stimulate numerous follow-up studies on its biological functions. …”
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    Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state
  3. 86683
    “…CONCLUSIONS: FMISO accumulates in hypoxic cells through reductive metabolism followed by glutathione conjugation. We illustrated the possibility that increased production and decreased excretion of amino-FMISO-GS contribute to FMISO accumulation in tumor cells under hypoxic conditions. …”
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    FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state
  4. 86684
    “…The high validation rate of our model illustrates the advantages of discrete dynamic modeling for complex, nonlinear systems common in biology.…”
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    A new discrete dynamic model of ABA-induced stomatal closure predicts key feedback loops
  5. 86685
    “…However, the Kaplan–Meier analysis illustrated no significant difference in the overall survivals between patients with high and low methylation levels of SOX1 or PAX1 (P>0.5). …”
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    DNA hypermethylated status and gene expression of PAX1/SOX1 in patients with colorectal carcinoma
  6. 86686
    “…Thirty-four (76%) interviewed patients had initiated PrEP, of whom 17 (50%) had subsequently discontinued their medication a mean of 92 days (95% confidence interval [CI]: ± 23.8) following receipt of a prescription. Figure 1 illustrates the PrEP care continuum for our clinic. …”
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    HIV Pre-Exposure Prophylaxis (PrEP) Uptake, Initiation, and Persistence in the Detroit Public Health STD Clinic
  7. 86687
    “…We employed the matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS) to illustrate the spatial distribution of a broad range of Aβ species in human autopsied brains. …”
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    Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry
  8. 86688
    por Wang, Kefeng, Jin, Wei, Song, Yan, Fei, Xiang
    Publicado 2017
    “…RESULTS: In this study, the qRT-PCR results illustrated that lncRNA RP11-436H11.5 was more highly expressed in RCC tissues than in adjacent normal renal tissues. …”
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    LncRNA RP11-436H11.5, functioning as a competitive endogenous RNA, upregulates BCL-W expression by sponging miR-335-5p and promotes proliferation and invasion in renal cell carcinoma
  9. 86689
    “…Western blot analysis of hydrophobic enamel proteins illustrated continuously increasing amelogenin levels from 1 dpn until 8 dpn, while enamelin peaked on days 1 and 2 dpn, and ameloblastin on days 1–5 dpn. …”
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    Integrative Temporo-Spatial, Mineralogic, Spectroscopic, and Proteomic Analysis of Postnatal Enamel Development in Teeth with Limited Growth
  10. 86690
    por Wang, Pei, Chen, Dong, Ma, Hongbing, Li, Yong
    Publicado 2017
    “…However, the molecular mechanism of MEG3 affecting DDP resistance in NSCLC remains to be further illustrated. In this study, we attempted to discuss whether MEG3 also could function as a competing endogenous RNA to regulate DDP resistance in NSCLC. …”
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    LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis
  11. 86691
    “…CONCLUSIONS: This study illustrates the importance of examining structural differences in online social networks as a critical component for network-based interventions and lays the foundation for future research that examines the ways that social networks differ based on individual health behavior. …”
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    An exploration of the Facebook social networks of smokers and non-smokers
  12. 86692
    “…Acute conditions and younger age groups had fewer problems with overall costs but more with not calling for help or going to a facility. An illustrative health systems interpretation suggests extending and promoting existing provisions for transport and financial access in this setting. …”
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    Moving from medical to health systems classifications of deaths: extending verbal autopsy to collect information on the circumstances of mortality
  13. 86693
    “…CONCLUSION: A comparative approach reiterates that evidence is not a uniform concept for which more is obviously better, but rather illustrates how different constructions and pieces of evidence become relevant in relation to the features of specific health policy decisions. …”
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    The many meanings of evidence: a comparative analysis of the forms and roles of evidence within three health policy processes in Cambodia
  14. 86694
    “…Epidemiological data reported through the routine surveillance system from January 2009 to June 2016 were analyzed to illustrate the contribution of case reporting from the private sector. …”
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    Expanding malaria diagnosis and treatment in Lao PDR: lessons learned from a public–private mix initiative
  15. 86695
    “…Importantly, other approaches targeting other conserved pan-CoV functions have not yet proven effective against MERS-CoV, illustrating the broad applicability of targeting viral 2′O-MTase function across CoVs.…”
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    Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis
  16. 86696
    “…Light microscopy and confocal immunofluorescence served to illustrate changes in the urinary sediment over the time course of renal function improvement. …”
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    The urine biomarker panel [IGFBP7]x[TIMP-2] (NephroCheck(®) parameter) does not correlate with IGFBP7 and TIMP-2 gene expression in urinary sediment
  17. 86697
    “…We identified plant species mentioned during interviews by their local Dutch names and illustrated field guides and floras. We hypothesized that people living in rural areas consumed more wild species than urban people. …”
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    Famine food of vegetal origin consumed in the Netherlands during World War II
  18. 86698
    “…CONCLUSIONS: This work illustrates the importance of following the circulating level of biomarker overtime. …”
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    S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study
  19. 86699
    “…Hypertrophic cardiomyopathy led to lower PCr/ATP ratios for high cardiac work rates, which was exacerbated by creatine depletion. Simulations illustrated that when conducting cardiac (31)P-MRS exercise stress testing with large measurement error margins, results obtained under pathophysiologic conditions may still lie well within the 95% confidence interval of normal myocardial PCr/ATP dynamics. …”
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    Human Cardiac (31)P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise
  20. 86700
    “…These results clearly illustrates the importance of simultaneously evaluating both abiotic and biotic factors on ITV(BI). …”
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    Biotic and abiotic drivers of intraspecific trait variation within plant populations of three herbaceous plant species along a latitudinal gradient
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