“…We evaluated the performance of the models through simulations and illustrated application of the methods using Alzheimer’s gene expression datasets. …”
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“…Further experiments illustrated that the regulation of committed HSC differentiation by Dlk1 was mediated by the AKT and MAPK signaling pathways. …”
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“…In this hypothesis, epigenetics appears as a hub by which non‐genetically inherited environmentally induced variation in traits can become genetically encoded over generations, in a form of epigenetically facilitated mutational assimilation. Finally, we illustrate some of the major implications of our hypothetical framework, concerning mutation randomness, the central dogma of molecular biology, concepts of inheritance and the curing of inherited disorders, as well as for the emergence of the inclusive evolutionary synthesis.…”
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“…Ducks likely use less energy for movement than currently predicted and management, including distribution and configuration of essential habitat, may require reconsideration. Our study illustrates how fine-scale movement data from tracking help understand and inform various other fields of research. …”
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“…RESULTS: The 8-Step Scoping Framework was described using the example of the local government organization Flying Start to illustrate how each step contributes to finding projects suitable for process and outcome evaluation: (1) formulating overarching key questions that encompass all programs offered by an organization, (2) gaining an in-depth understanding of the work and provision of an organization and engaging staff, (3) completing a data template per project/program offered, (4) assessing the robustness/validity of data across all programs, (5) deciding on projects suitable for evaluation and those requiring additional data, (6) negotiating with chosen project leads, both within and outside the organization, (7) developing individual project evaluation protocols, and (8) applying for ethical approval from the university and partner organization. …”
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“…The deleterious and compensatory effects of individual amino acid substitutions at positions 4008 and 3060 and in several different domains of VP2 illustrated that the chain-based spatial interaction patterns of VP1, VP2, and VP3 (VP1-3), as well as between the internal VP4 and the three external capsid proteins of FMDV, might contribute to the assembly of eventually viable viruses. …”
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“…This application of DNA sequencing technologies illustrates at a new level the highly dynamic nature of ST131 genomes.…”
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“…Blocking studies using Octreotide illustrated receptor-mediated uptake of [(47)Sc]Sc-DOTATOC in AR42J cells. …”
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“…The relationship between personality changes and panhypopituitarism is yet to be understood. This case illustrates the need to keep a high index of suspicion for endocrine and metabolic disorders in older adults with atypical presentation of delirium and self-neglect.References1. …”
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“…Since the patients have a history of poorly controlled diabetes and had hepatomegaly on ultrasound, GH was considered the most likely cause of the hepatomegaly. Our cases illustrate the following points: a. hepatomegaly in poorly controlled T1DM is likely GH. b. elevated lactate levels favor GH as elevated lactate levels are not seen in steatohepatitis, the caveat being that ultrasound cannot discriminate between the two conditions c. …”
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“…Initial biochemical testing to exclude conditions like PCC should always be considered prior to invasive procedures involving masses close to the adrenal gland, as manipulation or biopsy of a pheochromocytoma may have dreadful consequences. Our case illustrates the necessity of maintaining a broad differential when evaluating cases with RUQ abdominal masses which are close to the adrenal gland, and to consider other modalities of testing depending on the index of suspicion prior to biopsy of the mass.…”
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“…TB causes adrenal destruction in a gradual manner, targeting the medulla and cortex secondarily as illustrated here by this HIV-negative latent TB patient. …”
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“…Conclusion: This case illustrates the importance of close attention to lab parameters such as gamma gap and total protein and to musculoskeletal symptoms in patients presenting with a sellar mass that were later found to be secondary to MM. …”
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“…Background: Amiodarone-induced thyrotoxicosis (AIT) with concomitant amiodarone-induced isolated hyperbilirubinemia is rare, making it a diagnostic and therapeutic challenge. We report a case illustrating the complexities involved in managing such a patient. …”
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“…Overall plasma octreotide exposures for the test and reference drugs were comparable whilst subjects receiving MTD201 illustrated lower initial spike in plasma octreotide (burst; 0.12ng/mL and 0.99ng/mL for MTD201 and SLAR, respectively), a more linear, consistent profile, and lower variability across the intended dose interval (28 days). …”
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“…Conclusion: this case illustrates the feasibility of cortical sparing surgery in the long-term preservation of adrenocortical function, avoiding the potential risks associated with adrenal insufficiency, and could be considered as a first-line treatment approach.…”
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“…Introduction: This case illustrates an uncommon initial presentation of cardiomyopathy in a pregnant woman who was later found to have Pheochromocytoma. …”
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“…There are case reports of pituitary adenoma diagnosed through evaluation of sexual dysfunction and frequent hot flashes. This case illustrates the importance of considering broad etiologies when evaluating new onset hot flashes in middle-aged men, especially in the absence of other presenting features of pituitary macroadenoma and when symptoms of hypogonadism (like erectile dysfunction, low libido, impaired concentration and fatigue) go unreported to physicians.…”
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“…By reporting this case, we hope to raise the physician awareness about this rare phenomenon, and illustrate the potential mechanisms behind such change. …”
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“…This patient’s case illustrates the female predominance (1.5-2.5:1) and typical time of diagnosis (fifth-to-sixth decade) reported in adult cases of ACC. …”
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