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88361por Huang, Ming, Dong, Wen, Xie, Ruihui, Wu, Jilin, Su, Qiao, Li, Wuguo, Yao, Kai, Chen, Yuelong, Zhou, Qianghua, Zhang, Qiang, Li, Wenwen, Cheng, Liang, Peng, Shengmeng, Chen, Siting, Huang, Jian, Chen, Xu, Lin, Tianxin“…Herein, we aimed to illustrate the clinical roles and mechanisms of HSF1 in the lymphatic metastasis of bladder cancer and explore its therapeutic potential. …”
Publicado 2022
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88362por Dolciami, Daniela, Villasclaras-Fernandez, Eloy, Kannas, Christos, Meniconi, Mirco, Al-Lazikani, Bissan, Antolin, Albert A.“…Finally, we identify canonicalization enrichment in FDA-approved drugs, illustrating the benefits of our approach. RESULTS: We created a chemical registration and standardization pipeline in KNIME and made it freely available to the research community. …”
Publicado 2022
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88363por Silenou, Bernard C, Verset, Carolin, Kaburi, Basil B, Leuci, Olivier, Ghozzi, Stéphane, Duboudin, Cédric, Krause, Gérard“…OBJECTIVE: This study aims to describe the essential visualizations, surveillance indicators, and epidemiological parameters implemented in the SORMAS-Stats application and illustrate the application of SORMAS-Stats in response to the COVID-19 outbreak. …”
Publicado 2022
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88364por Huang, Jez, Li, Ying Betty, Charlebois, Claudie, Nguyen, Tina, Liu, Ziying, Bloemberg, Darin, Zafer, Ahmed, Baumann, Ewa, Sodja, Caroline, Leclerc, Sonia, Fewell, Gwen, Liu, Qing, Prabhakarpandian, Balabhaskar, McComb, Scott, Stanimirovic, Danica B., Jezierski, Anna“…The described BBB assay was able to discriminate the cytotoxic efficacies of different EGFRvIII-CARs and provide a measure of potential alterations to BBB integrity. Collectively, we illustrate how BBB models in vitro can be a valuable tool in deciphering the mechanisms of CAR-T–induced BBB disruption, accompanying toxicity and effector function on post-barrier target cells. …”
Publicado 2022
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88365por Helleputte, Simon, Van Bortel, Luc, Verbeke, Francis, Op ‘t Roodt, Jos, Calders, Patrick, Lapauw, Bruno, De Backer, Tine“…Cf-PWV strongly associates with the STENO risk score for future CV events and with cardiovascular imaging and function outcomes, thereby illustrating the clinical importance of arterial stiffness. …”
Publicado 2022
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88366por Zhang, Rui, Zhang, Qingqing, Chen, Yanni, Zhao, Qing, Zhang, Bo, Wang, Ling, Zhou, Chungen, Zhang, Qi, Chen, Kun, Zhang, Yuqing, Hou, Xiaotao, Chen, Hao, Liu, Xingyin, Ni, Min, Jiang, Bin“…Besides, we established that the combination of ADSC + Rg1 restored immunological balance more effectively than either ADSC or Rg1 alone, illustrating that Rg1's modulatory function on the gut microbiota may boost the impact of ADSCs in restoration of the immune balance. …”
Publicado 2022
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88367por Delahunt, Anna, Conway, Marie C., O’Brien, Eileen C., Geraghty, Aisling A., O’Keeffe, Linda M., O’Reilly, Sharleen L., McDonnell, Ciara M., Kearney, Patricia M., Mehegan, John, McAuliffe, Fionnuala M.“…CONCLUSIONS: In this cohort, the ecological factors examined had an influence on children’s eating behaviours aged 5-years-old. Our results illustrate the complexity of the relationship between the child’s environment, eating behaviour and children’s body composition. …”
Publicado 2022
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88368por Reid, Hadley Woodruff, Proeschold-Bell, Rae Jean, Makarushka, Christina, Melgar Vega, Katherine Dayllan, Huchko, Megan, Jeronimo, Jose, Vasudevan, Lavanya“…OBJECTIVE: We presented a case study on the use of an implementation science framework in mHealth design. In particular, we illustrated the usability of the Consolidated Framework for Implementation Research (CFIR) for organizing and interpreting formative research findings during the design of the mobile Inspección Visual con Ácido Acético (mIVAA) system in Lima, Peru. …”
Publicado 2022
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88369“…The results of ESTIMATE and CIBERSORT illustrated that there was a positive correlation between PD-L1 expression and immune infiltration, especially regulatory T cells and M1 macrophages. …”
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88370por Eissman, Jaclyn M, Dumitrescu, Logan, Mahoney, Emily R, Smith, Alexandra N, Mukherjee, Shubhabrata, Lee, Michael L, Scollard, Phoebe, Choi, Seo Eun, Bush, William S, Engelman, Corinne D, Lu, Qiongshi, Fardo, David W, Trittschuh, Emily H, Mez, Jesse, Kaczorowski, Catherine C, Hernandez Saucedo, Hector, Widaman, Keith F, Buckley, Rachel F, Properzi, Michael J, Mormino, Elizabeth C, Yang, Hyun Sik, Harrison, Theresa M, Hedden, Trey, Nho, Kwangsik, Andrews, Shea J, Tommet, Douglas, Hadad, Niran, Sanders, R Elizabeth, Ruderfer, Douglas M, Gifford, Katherine A, Zhong, Xiaoyuan, Raghavan, Neha S, Vardarajan, Badri N, Pericak-Vance, Margaret A, Farrer, Lindsay A, Wang, Li San, Cruchaga, Carlos, Schellenberg, Gerard D, Cox, Nancy J, Haines, Jonathan L, Keene, C Dirk, Saykin, Andrew J, Larson, Eric B, Sperling, Reisa A, Mayeux, Richard, Cuccaro, Michael L, Bennett, David A, Schneider, Julie A, Crane, Paul K, Jefferson, Angela L, Hohman, Timothy J“…Overall, we identified sex differences in the genetic architecture of resilience, identified a female-specific resilience locus and highlighted numerous sex-specific molecular pathways that may underly resilience to Alzheimer’s disease pathology. This study illustrates the need to conduct sex-aware genomic analyses to identify novel targets that are unidentified in sex-agnostic models. …”
Publicado 2022
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88371por Oehme, Stephan, Moewis, Philippe, Boeth, Heide, Bartek, Benjamin, Lippert, Annika, von Tycowicz, Christoph, Ehrig, Rainald, Duda, Georg N., Jung, Tobias“…No significant differences were observed for the rotational (16.3 ± 3.7° vs. 15.2 ± 3.6°, p = 0.43) and translational (17.0 ± 5.4 mm vs. 16.1 ± 2.8 mm, p = 0.55) range of anterior–posterior and rotational tibiofemoral motion during level walking conditions for PCL insufficient knees compared to CL knees respectively. The present study illustrates that patients with PCL insufficiency show a substantial increased passive tibiofemoral laxity, not only in tibiofemoral translation but also in tibiofemoral rotation. …”
Publicado 2022
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88372por Kamstra, Regina J M, Boorsma, André, Krone, Tanja, van Stokkum, Robin M, Eggink, Hannah M, Peters, Ton, Pasman, Wilrike J“…In addition, the correlation between the 2 app-based questionnaires was high (>0.73; P<.001), illustrating a high test-retest reliability, indicating it to be a reliable replacement for the paper-based questionnaire. …”
Publicado 2022
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88373“…CONCLUSION: Cette observation illustre la diversité des formes cliniques et la gravité de la COVID-19. …”
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88374por Amodan, Bob Omoda, Kisakye, Annet, Okumu, Patricia Thiwe, Ahirirwe, Sherry Rita, Kadobera, Daniel, Driwale, Alfred, Ario, Alex Riolexus“…We evaluated the trends in achieving the targeted NPAFP and SA rates from 2015–2020. We used QGIS to illustrate patterns in NPAFP and SA rates across districts and subregions. …”
Publicado 2022
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88375por Chiavi, Deborah, Haag, Christina, Chan, Andrew, Kamm, Christian Philipp, Sieber, Chloé, Stanikić, Mina, Rodgers, Stephanie, Pot, Caroline, Kesselring, Jürg, Salmen, Anke, Rapold, Irene, Calabrese, Pasquale, Manjaly, Zina-Mary, Gobbi, Claudio, Zecca, Chiara, Walther, Sebastian, Stegmayer, Katharina, Hoepner, Robert, Puhan, Milo, von Wyl, Viktor“…CONCLUSIONS: This study illustrates the timely and efficient applicability of an NLP pipeline and thereby serves as a precedent for applied researchers. …”
Publicado 2022
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88376por Nuccio, Erin E., Blazewicz, Steven J., Lafler, Marissa, Campbell, Ashley N., Kakouridis, Anne, Kimbrel, Jeffrey A., Wollard, Jessica, Vyshenska, Dariia, Riley, Robert, Tomatsu, Andy, Hestrin, Rachel, Malmstrom, Rex R., Firestone, Mary, Pett-Ridge, Jennifer“…CONCLUSIONS: Our semi-automated HT-SIP approach decreases operator time and improves reproducibility by targeting the most labor-intensive steps of SIP—fraction collection and cleanup. We illustrate this approach in a unique and understudied soil microhabitat—generating MAGs of actively growing microbes living in the AMF hyphosphere (without plant roots). …”
Publicado 2022
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88377por Quinones, Sarah, Palermo, Tia, Gavrilovic, Maja, Vinci, Vincenzo, Otchere, Frank, Mussa, Essa Chanie“…Qualitative data were analysed using thematic analysis combining both a fluid and more structured coding processes to unpack the important topics within the data supported by illustrative quotes. RESULTS: Our results show that knowledge of and interaction with SWs is limited while many knew of and interacted with HEWs quite regularly. …”
Publicado 2022
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88378por Verma, Shefali S., Keat, Karl, Li, Binglan, Hoffecker, Glenda, Risman, Marjorie, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Dudek, Scott, Verma, Anurag, Klein, Teri E., Ritchie, Marylyn D., Tuteja, Sony“…CONCLUSIONS: Clinically actionable PGx alleles are highly prevalent in our health system and many patients were prescribed medications that could be affected by PGx alleles. These results illustrate the potential utility of preemptive genotyping for tailoring of medications and implementation of PGx into routine clinical care. …”
Publicado 2022
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88379“…Bioinformatic analysis illustrated the 3′UTRs of glycolysis enzymes contained multiple PTBP1 binding sites, which were further verified by RNA pull-down and RNA immunoprecipitation assays. …”
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88380por Pakravan, Katayoon, Mossahebi-Mohammadi, Majid, Ghazimoradi, Mohammad H., Cho, William C., Sadeghizadeh, Majid, Babashah, Sadegh“…Western blotting, enzyme-linked immunosorbent assay, RT-qPCR, flow cytometry staining, migration assay, immunohistochemical staining, and bioinformatics analysis were performed to reveal the underlying mechanisms. RESULTS: We illustrated that primary CAFs recruited monocytes and established pro-tumoral M2 macrophages. …”
Publicado 2022
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