“…Conclusion: The case above illustrates prolonged action of degludec causing hypoglycemia 10 days after stopping prescription dose (0.1U/kg) of degludec, which has not been previously reported before.Reduced oral intake potentiated hypoglycemic episodes. …”
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“…More broadly, this study demonstrates how deep intronic mutations may be a cause of false negative genetic test results and illustrates the expanding utility of NGS methodologies across heritable disorders.…”
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“…Shannon index was associated with site (lower nasal diversity than oral and sputum diversity, p<0.001), but not age, ICS use, FEV1pp, tobacco use, or edentulous state. β-diversity was illustrated by principal coordinate analysis using Bray-Curtis dissimilarity and PERMANOVA analyses, showing sample clustering by anatomic site (p = 0.001) with nasal samples forming a cluster separate from the combined oral wash samples and sputum samples. …”
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“…In these first main-group metal–prehnitene complexes, the distorted η(6) arene π-bonding to the tin atoms of the Sn(2)Cl(2) (2+) moieties in the centre of [{1,2,3,4-(CH(3))(4)C(6)H(2)}(2)Sn(2)Cl(2)][MCl(4)](2) repeating units (site symmetry [Image: see text]) is characterized by: (i) a significant ring slippage of ca 0.4 Å indicated by the dispersion of Sn—C distances [1: 2.881 (2)–3.216 (2) Å; 2: 2.891 (3)–3.214 (3) Å]; (ii) the non-methyl-substituted arene C atoms positioned closest to the Sn(II) central atom; (iii) a pronounced tilt of the plane of the arene ligand against the plane of the central (Sn(2)Cl(2))(2+) four-membered ring species [1: 15.59 (11)°, 2: 15.69 (9)°]; (iv) metal–arene bonding of medium strength as illustrated by application of the bond-valence method in an indirect manner, defining the π-arene bonding inter­action of the Sn(II) central atoms as s(Sn(II)—arene) = 2 − Σs(Sn(II)—Cl), that gives s(Sn(II)—arene) = 0.37 and 0.38 valence units for the aluminate and the gallate, respectively, indicating that comparatively strong main-group metal–arene bonding is present and in line with the expectation that [AlCl(4)](−) is the slightly weaker coordinating anion as compared to [GaCl(4)](−).…”
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“…CONCLUSION: The development and implementation of the Pantothenate Kinase-Associated Neurodegeneration–Activities of Daily Living scale in the FOsmetpantotenate Replacement Therapy trial illustrates the feasibility and potential patient benefit of putting into practice the current regulatory guidance on the use of patient-reported outcomes in clinical trials. …”
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“…CONCLUSIONS: Our findings illustrate the vulnerabilities of children born to foreign women from low and middle-income countries. …”
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“…In this study, we aimed to investigate the implications of alternative strategies for offering blood pressure treatment, using the UK as an illustrative example. METHODS: We did a retrospective cohort study in primary care patients aged 30–79 years without cardiovascular disease, using data from the UK's Clinical Practice Research Datalink linked to Hospital Episode Statistics and Office for National Statistics mortality. …”
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“…KEY LEARNING POINTS: This case highlights the importance of considering ’undifferentiated systemic autoinflammatory disorder’ or ’atypical adult-onset Still’s disease’ as a potential diagnosis for the subgroup of patients presenting atypically who do not fulfil any current classification or diagnostic criteria for a specific autoinflammatory disease. This case also illustrates that IL-1 blockade is potentially a viable treatment option in these patients. …”
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“…The richness and complexity of these organizational linkages illustrates the decentralized nature of Informatics at the institution and the promise of the cluster approach. …”
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“…With a large proportion of our sample having an AIDS diagnosis at enrollment, we illustrate the ongoing challenge of late HIV diagnosis in DC. …”
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“…Finally, the 4-day HIV-infection protection study result illustrates IC(50) in case of XFCCR5-FTC+DTG NP and XFCCR5 NP to be as low as 0.0069 and 0.0031 µg/mL, respectively, compared with 1.771 µg/mL for XFCCR5 mAb (Figure 1, TZM-bl and Figure 2, PBMCs). …”
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“…CONCLUSION: nAb against CMV PC-mediated cell entry did not appear to play a critical role in viral clearance in SL CMV infection after CMV D+/R- allogeneic HCT. Our study illustrates the potential for clearance of relatively low CMV DNAemia after HCT without the addition of antivirals. …”
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“…Although there is increasing evidence regarding the efficacy of such approaches, as illustrated by quantitative systematic reviews, the literature has also highlighted challenges with implementation factors, including high attrition rates and variable user engagement. …”
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“…GIP also modified adipogenesis by accelerating MCE, upregulating core transcription factor (PPARγ and C/EBPα), increasing beige-related markers (UCP1, PGC1α, PRDM16, et al) while suppressing white-related genes (ZFP423 and TLE3). In summary, we illustrated the efficacies of GIP on proliferation, apoptosis and adipogenesis (especially the beige adipocyte formation) of ADSCs, providing evidence of the additional metabolic benefits of GIP/GLP-1 dual-target agonist over GLP-1 agonist monotherapy in vivo.…”
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“…The patient was started on a regimen of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine, with excellent clinical response. This case illustrates an atypical, hypercalcemia-driven initial presentation of Hodgkin’s lymphoma. …”
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“…This scenario was most consistent with hyperglycemia due to insulin resistance and subsequent relative insulin deficiency during stress, with continued PTx function. This illustrates the importance of detailed assessment and personalized treatment in patients with post-PTx hyperglycemia.…”
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“…However, resolution of hypercalcemia with resection of the mass supports a diagnosis of hypercalcemia of malignancy. This case illustrates that hypercalcemia due to primary cutaneous SCC typically, but not always, results in an elevated serum PTHrP level.…”
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“…Pembrolizumab, a programmed death 1 (PD-1) inhibitor used for advanced malignancies, can be associated with thyroid dysfunction.(1-2) Specifically, thyroiditis occurs in nearly 2.3% of individuals.(2) The hyperthyroid phase is typically non-severe, requiring only beta blockers. Our case illustrates that conservative therapies may be ineffective in pembrolizumab-induced severe thyroiditis. …”
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“…Most patients have benefited clinically post-ablation. This is illustrated by a 65-year-old man with previously uncontrolled hypertension despite 4 antihypertensive medications, including spironolactone. …”
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“…Conclusion: Although Swyer syndrome is uncommon with an incidence of 1 in 80,000, this case illustrates that suspicion for Swyer Syndrome should be high in patients with slow progression of puberty and primary amenorrhea (1). …”
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