“…In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy.…”
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“…CONCLUSIONS: This retrospective study illustrated that age, anemia status, zinc deficiency and vitamin D were associated with anti-HBs expression in specific age groups of children, which could serve as a reference for the prevention of HBV. …”
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“…In this review, we summarize the latest studies on various types of RNA biomarkers, especially extracellular RNAs, in cancer diagnosis and prognosis, and illustrate several well-known RNA biomarkers of clinical utility. …”
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“…Together, these findings illustrate the neural correlates of orthographic access for Mandarin Chinese writing, shedding new light on the cognitive architecture of writing across various writing systems.…”
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“…Periodic mutation profiling of patient's circulating tumor DNA (ctDNA) by next generation sequencing (NGS) revealed a number of genetic alterations including re-occurrence of MET amplification, multiple secondary MET mutations, a dramatic increase of FGFR2 gene relative copy number as well as mutations in other downstream and bypassing elements, which may collectively related to the patient's cancer progression. Our results illustrate the complex and heterogeneous molecular mechanisms for crizotinib resistance in this patient, and demonstrate the great potential of ctDNA profiling for treatment decision-making and prognosis in clinical practice.…”
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“…METHODS: We assess how the two established decomposition methods yield varying results with three-factor factorial experimental designs, illustrating that they are sensitive to the choice of the reference group. …”
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“…Phylogenetic analysis illustrates that C. minima is closely related to other Asteraceae species, including Helianthus annuus subsp. texanus, Tithonia diversifolia and Xanthium sibiricum with a strong bootstrap value of 100.…”
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“…The results from the current study illustrated a well-established bioinks system with the potential to construct different tissues through 3D bioprinting.…”
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“…These simulation results illustrate the feasibility of integrating NVCTs into functional circuits and provide a theoretical method for future on-chip vacuum transistors applied in logic or radio-frequency (RF) devices.…”
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“…We additionally conducted an in-depth, two-generation pedigree analysis to further illustrate the mode of inheritance in this case.…”
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“…These high-resolution structures illustrate the molecular details of the extensive hydrophobic interactions and the network of main chain hydrogen bonds formed between the NNRTIs and the RT inhibitor-binding pocket, and provide valuable insights into the favorable structural features that can be employed for designing NNRTIs that are broadly active against drug-resistant HIV-1 variants.…”
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“…The in vitro degradation and drug release evaluation illustrated the potential for long-term release of DP. …”
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“…First, the working mechanism of DPP-BOTDA is introduced to illustrate the reason that the DPP-BOTDA, compared to traditional BOTDA technique, can significantly improve the spatial resolution of distributed strain sensing, which is critical for structural crack detection. …”
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“…Regarding BAW devices, we give particular attention to film bulk acoustic resonators (FBARs), due to their advantages in terms of high frequency operation and integrability. Examples illustrating their application as RF filters, physical sensors and actuators, and biochemical sensors are presented. …”
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“…Experimental results illustrate that the peak strength is observed under single-stage aging at 180 °C × 3 h, with a tensile strength of 332.5 MPa, Brinell hardness of 133.0 HB, and elongation of 5.56%. …”
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“…It remains unknown what and how the underlying risk factors were involved in the bird-to-human cross-species transmission. To illustrate the dynamics of viral spread, we created a thematic map displaying the distribution of affected counties and plotted epidemic curves for the three most affected provinces and the whole country. …”
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“…Opposing exchange kinetics, suitable for the special structure of the fiber, were developed for describing the exchange process with the help of thermodynamics, which illustrated that the load was controlled by an ionic reaction. …”
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“…The accelerated age-related hearing loss (ARHL) of the Ocm KO illustrates the importance of Ca(2+) signaling in maintaining hearing health. …”
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“…Here, we use porcine epidemic diarrhea virus (PEDV) as a model of CoVs to illustrate the reciprocal regulation between CoV infection and pyroptosis. …”
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“…Overall, our results illustrated the clear indicative role of wastewater surveillance in combating COVID-19 and provided a practical basis for rapidly expanding the feasibility and value of routine wastewater surveillance for future emerging infectious diseases.…”
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