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  1. 54681
    “…We were able to salvage some of the failures so that at followup, 90 patients (90 of 101 [89%]) had a MUTARS(®) in situ. CONCLUSIONS: Although no system has yet proved ideal to restore normal function and demonstrate long-term retention of the implant, MUTARS(®) modular endoprostheses represent a reliable long-term option for knee replacement after tumor resection, which seems to be comparable to other modular implants available to surgeons. …”
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    What Are the Long-term Results of MUTARS(®) Modular Endoprostheses for Reconstruction of Tumor Resection of the Distal Femur and Proximal Tibia?
  2. 54682
    por Colafrancesco, Serena, Priori, Roberta, Valesini, Guido, Argolini, Lorenza, Baldissera, Elena, Bartoloni, Elena, Cammelli, Daniele, Canestrari, Giovanni, Cantarini, Luca, Cavallaro, Elena, Cavalli, Giulio, Cerrito, Lucia, Cipriani, Paola, Dagna, Lorenzo, Marchi, Ginevra De, Vita, Salvatore De, Emmi, Giacomo, Ferraccioli, Gianfranco, Frassi, Micol, Galeazzi, Mauro, Gerli, Roberto, Giacomelli, Roberto, Gremese, Elisa, Iannone, Florenzo, Lapadula, Giovanni, Lopalco, Giuseppe, Manna, Raffaele, Mathieu, Alessandro, Montecucco, Carlomaurizio, Mosca, Marta, Piazza, Ilaria, Piga, Matteo, Pontikaki, Irene, Romano, Micol, Rossi, Silvia, Rossini, Maurizio, Ruscitti, Piero, Silvestri, Elena, Stagnaro, Chiara, Talarico, Rosaria, Tincani, Angela, Viapiana, Ombretta, Vitiello, Gianfranco, Fabris, Francesca, Bindoli, Sara, Punzi, Leonardo, Galozzi, Paola, Sfriso, Paolo
    Publicado 2017
    “…Adverse events (AEs) [mainly represented by in situ (28/47, 59.5%) or diffuse (12/47, 25.5%) skin reactions and infections (7/47, 14.8%)] were the main causes for discontinuation. …”
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    Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still’s Disease: A Multicentre Retrospective Observational Study
  3. 54683
    “…OBJECTIVE: The primary objective of both studies is to develop descriptive criteria for in vivo CLE images of urothelial carcinoma (low-grade, high-grade, carcinoma in situ) and normal urothelium by comparing CLE images with corresponding histopathology. …”
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    Confocal Laser Endomicroscopy for the Diagnosis of Urothelial Carcinoma in the Bladder and the Upper Urinary Tract: Protocols for Two Prospective Explorative Studies
  4. 54684
    “…Types of sequence-based taxa, which by default lack a physical specimen or culture, could be designated in four alternative ways: (1) the underlying sample (‘bag’ type), (2) the DNA extract, (3) fluorescent in situ hybridization (FISH), or (4) the type sequence itself. …”
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    Formal description of sequence-based voucherless Fungi: promises and pitfalls, and how to resolve them
  5. 54685
    “…Luciferase reporter, RNA-binding protein immunoprecipitation (RIP), RNA pull-down and fluorescence in situ hybridization (FISH) assays were employed to test the interaction between circPTK2 and miR-429/miR-200b-3p. …”
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    Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer
  6. 54686
    “…METHODS: Our study included 73 women with early-stage breast cancer or ductal carcinoma in situ (DCIS) receiving post-operative RT but not chemotherapy. …”
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    Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer
  7. 54687
    “…Silvicultural management (in situ management in forests) was recorded in all species of mushrooms, as well as in more than 80% of medicinal, ceremonial and ornamental plants, and in more than 50% of the edible plants. …”
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    Cultural, economic, and ecological factors influencing management of wild plants and mushrooms interchanged in Purépecha markets of Mexico
  8. 54688
    “…METHODS: The expression levels of miR-10b-3p in ESCC specimens were analyzed by in situ hybridization (ISH) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. …”
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    Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
  9. 54689
    “…Pretreatment biopsies were used for HPV DNA determination via polymerase chain reaction, in situ hybridization for E6 and E7 messenger RNA (mRNA), and immunohistochemistry for the proteins p16(INK4A) and p53. …”
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    Survival Rates for Patients With Barrett High-grade Dysplasia and Esophageal Adenocarcinoma With or Without Human Papillomavirus Infection
  10. 54690
    “…The subcellular distribution of circPPP1R12A was analyzed by nuclear mass separation assay and fluorescence in situ hybridization (FISH). SDS-PAGE and LC/MS were employed to evaluate the protein-coding ability of circPPP1R12A. …”
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    A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling
  11. 54691
    “…Digital phenotyping refers to moment-by-moment quantification of the individual-level human phenotype in situ using data from personal digital devices, in particular, mobile phones. …”
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    “How Is My Child’s Asthma?” Digital Phenotype and Actionable Insights for Pediatric Asthma
  12. 54692
    “…A Duolink assay was performed to investigate in situ IL-20 receptor protein interactions in HTM or dermal fibroblasts, and Imaris software was used to quantitate the association of the heterodimeric complexes. …”
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    Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture
  13. 54693
    “…The protein and mRNA levels of relevant factors were analyzed using Western blotting, immunofluorescence and real time-quantitative PCR. The in situ expression of KMT2D in both human PDAC and paired adjacent normal tissues was determined by immunohistochemistry. …”
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    KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma
  14. 54694
    “…Finding steep incidence increases of invasive stage (beyond in situ) cases of colorectal cancer from age 49 to 50 years would be consistent with high rates of preexisting, undetected cancers in younger patients ultimately receiving a diagnosis of colorectal cancer after undergoing screening at 50 years. …”
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    Trends in Incidence of Early-Onset Colorectal Cancer in the United States Among Those Approaching Screening Age
  15. 54695
    “…Based on our data, stable left in situ lateral meniscus tears appear to show a better prognosis than medial tears. …”
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    Management of traumatic meniscus tears: the 2019 ESSKA meniscus consensus
  16. 54696
    “…Biopsy was consistent with a mesenchymal tumor and chromogenic in situ hybridization (Mayo Clinic) was positive for FGF23 mRNA. …”
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    SAT-385 A Normal FGF23 Does Not Preclude Tumor Induced Osteomalacia (TIO)
  17. 54697
    “…Incision and drainage (I&D) drained 100 cc of pus and drains were left in situ. Cultures grew MRSA. Patient was treated with vancomycin, clindamycin, and metronidazole. …”
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    MON-463 Thyroid Abscess Due to Intravenous Drug Use: A Rare Cause of Thyroid Storm
  18. 54698
    “…RIMA has a higher preoperative blood flow and a lower value of the PI than LIMA; however, there were no significant difference between RIMA grafted to LAD and LIMA grafted to LAD in terms of MGF, PI and DF. In situ skeletonized RIMA did not increase blood flow compared to pedicled LIMA.…”
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    Use of the right internal mammary artery and the great saphenous vein for left anterior descending artery revascularization in patients whose left internal mammal artery cannot be used: a study based on transit-time flow measurement
  19. 54699
    “…METHODS: Based on the presence of matrix metalloproteinases that are overexpressed at the fracture site, we designed the matrix metalloproteinase–sensitive nanocapsules which were formed by in situ free radical polymerisation on the surface of MiR-21 with 2-(methacryloyloxy) ethyl phosphorylcholine and the bisacryloylated VPLGVRTK peptide. …”
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    MiR-21 nanocapsules promote early bone repair of osteoporotic fractures by stimulating the osteogenic differentiation of bone marrow mesenchymal stem cells
  20. 54700
    “…RESULT: Among the five isolates obtained by in situ enrichment on various substrates, B. aerius CMCPS1, isolated from hot springs, exhibited the maximum hydrolytic activity of 4.11. …”
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    Thermotolerant glycosyl hydrolases-producing Bacillus aerius CMCPS1 and its saccharification efficiency on HCR-laccase (LccH)-pretreated corncob biomass
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