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  1. 54781
    “…In the IVa-p group (HSIL, severe dysplasia), 67.7% had CIN 2+ and 56.5% had CIN 3+, adenocarcinoma in situ (AIS), and adenocarcinoma. If the histology of the excised tissue specifically based on the colposcope findings was also evaluated, CIN 2+ was found in 79.7% of cases, and CIN 3+ in 67.3% of cases. …”
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    Registry Study of the Working Group on Cervical Pathology and Colposcopy (AGCPC) on the Diagnostic Algorithm for the New Cervical Cancer Screening – Initial Data
  2. 54782
    “…Mechanistically, dual luciferase reporter assays, fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP) and RNA pull-down experiments were performed to confirm the underlying mechanisms of circHERC1. …”
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    CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
  3. 54783
    por Foot, Nathan Chandler
    Publicado 1923
    “…In both cases the cells are, apparently, formed in situ rather than transported to the organs. He says: ‘Such findings suggest the development of a compensatory function on the part of the lymph-nodes and possibly the liver,’ and suggests that, in times of stress ‘the stellate cells of the liver thus assume, in part at least, the function of destroying red blood-corpuscles by phagocytosis.’ …”
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    STUDIES ON ENDOTHELIAL REACTIONS : VIII. CHANGES IN THE DISTRIBUTION OF TUBERCLE BACILLI AND TUBERCLES IN THE ORGANS OF RABBITS FOLLOWING SPLENECTOMY.
  4. 54784
    por Hubbard, Ruth, Wald, George
    Publicado 1952
    “…The retina obtains new supplies of the neo-b isomer: (a) by the isomerization of all-trans retinene in the eye by blue or violet light; (b) by exchanging all-trans vitamin A for new neovitamin Ab from the blood circulation; and (c) the eye tissues may contain enzymes which catalyze the isomerization of retinene and vitamin A in situ. When the all-trans retinene which results from bleaching rhodopsin in orange or yellow light is exposed to blue or violet light, its isomerization is accompanied by a fall in extinction and a shift of absorption spectrum about 5 mµ toward shorter wave lengths. …”
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    CIS-TRANS ISOMERS OF VITAMIN A AND RETINENE IN THE RHODOPSIN SYSTEM
  5. 54785
    por Chalfie, Martin
    Publicado 2010
    “…At the time, all methods of examining localization, such as antibody staining or in situ hybridization, required fixation of the tissue or cells, revealing the location of proteins only at fixed points in time. …”
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    The 2009 Lindau Nobel Laureate Meeting: Martin Chalfie, Chemistry 2008
  6. 54786
    por Tamburini, Christian, Canals, Miquel, Durrieu de Madron, Xavier, Houpert, Loïc, Lefèvre, Dominique, Martini, Séverine, D'Ortenzio, Fabrizio, Robert, Anne, Testor, Pierre, Aguilar, Juan Antonio, Samarai, Imen Al, Albert, Arnaud, André, Michel, Anghinolfi, Marco, Anton, Gisela, Anvar, Shebli, Ardid, Miguel, Jesus, Ana Carolina Assis, Astraatmadja, Tri L., Aubert, Jean-Jacques, Baret, Bruny, Basa, Stéphane, Bertin, Vincent, Biagi, Simone, Bigi, Armando, Bigongiari, Ciro, Bogazzi, Claudio, Bou-Cabo, Manuel, Bouhou, Boutayeb, Bouwhuis, Mieke C., Brunner, Jurgen, Busto, José, Camarena, Francisco, Capone, Antonio, Cârloganu, Christina, Carminati, Giada, Carr, John, Cecchini, Stefano, Charif, Ziad, Charvis, Philippe, Chiarusi, Tommaso, Circella, Marco, Coniglione, Rosa, Costantini, Heide, Coyle, Paschal, Curtil, Christian, Decowski, Patrick, Dekeyser, Ivan, Deschamps, Anne, Donzaud, Corinne, Dornic, Damien, Dorosti, Hasankiadeh Q., Drouhin, Doriane, Eberl, Thomas, Emanuele, Umberto, Ernenwein, Jean-Pierre, Escoffier, Stéphanie, Fermani, Paolo, Ferri, Marcelino, Flaminio, Vincenzo, Folger, Florian, Fritsch, Ulf, Fuda, Jean-Luc, Galatà, Salvatore, Gay, Pascal, Giacomelli, Giorgio, Giordano, Valentina, Gómez-González, Juan-Pablo, Graf, Kay, Guillard, Goulven, Halladjian, Garadeb, Hallewell, Gregory, van Haren, Hans, Hartman, Joris, Heijboer, Aart J., Hello, Yann, Hernández-Rey, Juan Jose, Herold, Bjoern, Hößl, Jurgen, Hsu, Ching-Cheng, de Jong, Marteen, Kadler, Matthias, Kalekin, Oleg, Kappes, Alexander, Katz, Uli, Kavatsyuk, Oksana, Kooijman, Paul, Kopper, Claudio, Kouchner, Antoine, Kreykenbohm, Ingo, Kulikovskiy, Vladimir, Lahmann, Robert, Lamare, Patrick, Larosa, Giuseppina, Lattuada, Dario, Lim, Gordon, Presti, Domenico Lo, Loehner, Herbert, Loucatos, Sotiris, Mangano, Salvatore, Marcelin, Michel, Margiotta, Annarita, Martinez-Mora, Juan Antonio, Meli, Athina, Montaruli, Teresa, Moscoso, Luciano, Motz, Holger, Neff, Max, Nezri, Emma nuel, Palioselitis, Dimitris, Păvălaş, Gabriela E., Payet, Kevin, Payre, Patrice, Petrovic, Jelena, Piattelli, Paolo, Picot-Clemente, Nicolas, Popa, Vlad, Pradier, Thierry, Presani, Eleonora, Racca, Chantal, Reed, Corey, Riccobene, Giorgio, Richardt, Carsten, Richter, Roland, Rivière, Colas, Roensch, Kathrin, Rostovtsev, Andrei, Ruiz-Rivas, Joaquin, Rujoiu, Marius, Russo, Valerio G., Salesa, Francisco, Sánchez-Losa, Augustin, Sapienza, Piera, Schöck, Friederike, Schuller, Jean-Pierre, Schussler, Fabian, Shanidze, Rezo, Simeone, Francesco, Spies, Andreas, Spurio, Maurizio, Steijger, Jos J. M., Stolarczyk, Thierry, Taiuti, Mauro G. F., Toscano, Simona, Vallage, Bertrand, Van Elewyck, Véronique, Vannoni, Giulia, Vecchi, Manuela, Vernin, Pascal, Wijnker, Guus, Wilms, Jorn, de Wolf, Els, Yepes, Harold, Zaborov, Dmitry, De Dios Zornoza, Juan, Zúñiga, Juan
    Publicado 2013
    “…In a setting where dense water formation events are likely to decline under global warming scenarios enhancing ocean stratification, in situ observatories become essential as environmental sentinels for the monitoring and understanding of deep-sea ecosystem shifts.…”
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    Deep-Sea Bioluminescence Blooms after Dense Water Formation at the Ocean Surface
  7. 54787
    “…The presence of up to 80 % of surrounding non-tumor tissue including in situ carcinoma did not affect the assay output. Sixteen out of 20 RNXtract eluates yielded more than 50 ng/μl of RNA (average RNA output: 233 ng/μl), whereas DNA contamination per sample was restricted to less than 15 ng/μl. …”
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    Technical validation of an RT-qPCR in vitro diagnostic test system for the determination of breast cancer molecular subtypes by quantification of ERBB2, ESR1, PGR and MKI67 mRNA levels from formalin-fixed paraffin-embedded breast tumor specimens
  8. 54788
    por Liu, Philip K., Liu, Christina H.
    Publicado 2016
    “…To validate the MRI results we used ex vivo methods including in situ hybridization, RT-PCR, immunohistochemistry, and transmision electron microscopy. …”
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    Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling
  9. 54789
    “…METHODS: MiR (miR-23a-3p, 27a-3p, 29a-3p, 100-5p, 127-3p and 486-5p) expression in the villi, decidual tissues and peripheral blood plasma and serum were validated by qPCR, and the localization of miRs in the villi and decidual tissues of RM and normal pregnancy (NP) women were detected by in situ hybridization. The invasiveness of HTR8/SVneo cells was determined using a Transwell assay. …”
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    Association of the peripheral blood levels of circulating microRNAs with both recurrent miscarriage and the outcomes of embryo transfer in an in vitro fertilization process
  10. 54790
    por Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O’Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E., Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon-Puay, Larsson, Susanna C., Linet, Martha S., Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A., Milne, Roger L., Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J.
    Publicado 2018
    “…MAIN OUTCOMES AND MEASURES: Invasive or in situ premenopausal breast cancer. RESULTS: Among the 758 592 premenopausal women (median age, 40.6 years; interquartile range, 35.2-45.5 years) included in the analysis, inverse linear associations of BMI with breast cancer risk were found that were stronger for BMI at ages 18 to 24 years (HR per 5 kg/m(2) [5.0-U] difference, 0.77; 95% CI, 0.73-0.80) than for BMI at ages 45 to 54 years (HR per 5.0-U difference, 0.88; 95% CI, 0.86-0.91). …”
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    Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women
  11. 54791
    “…Viability and cytotoxicity were determined by cell cycle and quantitative real-time PCR analyses were used to quantify levels of miR-200c and its target genes. In situ hybridization was used to visualize patterns of expression of miR-200c and others in the lung and many organs. …”
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    Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells
  12. 54792
    “…METHODS: About 1195 consecutive surgically resected CRCs were analyzed by immunohistochemical staining (IHC) to assess HER2 protein expression, and 141 selected tumors were further evaluated by fluorescence in situ hybridization (FISH) to assess HER2 gene amplification. …”
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    Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas
  13. 54793
    “…The HDC treatment was 15 mg/mL type-I collagen mixed with 0.06mM riboflavin, injected at the defect site and crosslinked in situ with blue light. The NP injection was HA modified with C16 side chains to increase the viscosity of the hydrogel (HYADD 4®)6. …”
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    3013 Combined Annulus Fibrosus and Nucleus Pulposus Repair Prevents Degeneration in the Ovine Lumbar Spine
  14. 54794
    “…At 4 years follow-up, the HPV vaccines reduced HPV-related carcinoma in situ (367 in the HPV vaccine group vs. 490 in the comparator group, RR 0.73 [95% confidence interval, CI, 0.53 to 1.00], number needed to vaccinate [NNV] 387, P = 0.05, I(2) = 67%) and HPV-related treatment procedures (1018 vs. 1416, RR 0.71 [95% CI 0.63 to 0.80], NNV 75, P < 0.00001, I(2) = 45%). …”
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    Benefits and harms of the human papillomavirus (HPV) vaccines: systematic review with meta-analyses of trial data from clinical study reports
  15. 54795
    “…Once inside the cell, Cys combines with glutamate (Glu) to initiate GSH synthesis in a reaction that is catalyzed by gamma-glutamyl cysteine ligase (GCL), the rate-limiting enzyme. Likely due to the in situ reaction of NAC-supplied Cys with Glu to spur GSH synthesis, NAC is believed to have anti-glutamatergic properties. …”
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    T165. ANTI-GLUTAMATERGIC PROPERTY OF N-ACETYLCYSTEINE DOCUMENTED IN VIVO WITH 1H MRS
  16. 54796
    “…TargetScan was used for in situ prediction of miR-203 targets and in vitro heterologous reporter assays using the wild-type and miR-203 seed mutant of the 3′ Untranslated region (UTR) of USP26 were used to investigate whether USP26 is a target of miR-203. …”
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    Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1’s pro-metastatic functions in esophageal cancer
  17. 54797
    “…MATÉRIELS ET MÉTHODES: Nous avons récolté des données sur la réponse épidémique dans un hôpital prenant en charge des patients infectés par le SARS-CoV-2 à l’aide de plusieurs sources : entretiens individuels semi-structurés, périodes d’observation ethnographique in situ et analyse documentaire. Les entretiens ont été réalisés auprès des différents professionnels de l’hôpital. …”
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    Quelles sont les conséquences de l’épidémie COVID-19 sur l’organisation des soins ?
  18. 54798
    “…In the real-world setting, no statistically significant differences in long-term outcomes with P vs PCT were observed; a prospective randomized trial addressing the comparative efficacy of P and PCT in different patient subgroups is highly anticipated.List of abbreviations: AE - adverse events; ALK - anaplastic lymphoma kinase gene; ALT - alanine aminotransferase; (a)NSCLC - (advanced) non-small cell lung cancer; AST - aspartate aminotransferase; BRAF - v-Raf murine sarcoma viral oncogene homolog B; BRCA2 - BReast CAncer gene 2; c-Met - tyrosine-protein kinase Met; CTCAE, v. 4.03 - Common Terminology Criteria for Adverse Events, version 4.03; CTLA-4 - cytotoxic T-lymphocyte-associated protein 4; ECOG PS - Eastern Cooperative Oncology Group performance status; EGFR - epidermal growth factor receptor gene; FISH - fluorescent in situ hybridization; HER2 - human epidermal growth factor receptor 2; IC - tumor-infiltrating immune cells; ICI - immune check-point inhibitors; IHC - immunohistochemistry; IQR - interquartile range; irAE - immune related adverse events; ISCORT - Israeli Society for Clinical Oncology and Radiotherapy; KRAS - Kirsten rat sarcoma viral oncogene homolog; (m)TTD -(median) time-to-treatment discontinuation; mo - months; (m)OS - (median) overall survival; (m)PFS - (median) progression-free survival; muts/Mb - mutations per megabase; NA - not specified/not available; NOS - not otherwise specified; NR - not reported/not reached; ORR - objective response rate; P - pembrolizumab; PCR - polymerase chain reaction; PCT - combination of pembrolizumab with platinum-based chemotherapy; PD – progression of disease; PD-1 - programmed cell death-1; PD-L1 - programmed cell death ligand-1; pts - patients; RET - proto-oncogene RET; ROS1 - proto-oncogene tyrosine-protein kinase ROS1; SD - standard deviation; STK11 - serine/threonine kinase 11; TC - tumor cells; TMB - Tumor mutation burden; TPS - tumor proportion score.…”
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    Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data
  19. 54799
    por Delorey, Toni M., Ziegler, Carly G. K., Heimberg, Graham, Normand, Rachelly, Yang, Yiming, Segerstolpe, Asa, Abbondanza, Domenic, Fleming, Stephen J., Subramanian, Ayshwarya, Montoro, Daniel T., Jagadeesh, Karthik A., Dey, Kushal K., Sen, Pritha, Slyper, Michal, Pita-Juárez, Yered H., Phillips, Devan, Bloom-Ackerman, Zohar, Barkas, Nick, Ganna, Andrea, Gomez, James, Normandin, Erica, Naderi, Pourya, Popov, Yury V., Raju, Siddharth S., Niezen, Sebastian, Tsai, Linus T.-Y., Siddle, Katherine J., Sud, Malika, Tran, Victoria M., Vellarikkal, Shamsudheen K., Amir-Zilberstein, Liat, Atri, Deepak S., Beechem, Joseph, Brook, Olga R., Chen, Jonathan, Divakar, Prajan, Dorceus, Phylicia, Engreitz, Jesse M., Essene, Adam, Fitzgerald, Donna M., Fropf, Robin, Gazal, Steven, Gould, Joshua, Grzyb, John, Harvey, Tyler, Hecht, Jonathan, Hether, Tyler, Jane-Valbuena, Judit, Leney-Greene, Michael, Ma, Hui, McCabe, Cristin, McLoughlin, Daniel E., Miller, Eric M., Muus, Christoph, Niemi, Mari, Padera, Robert, Pan, Liuliu, Pant, Deepti, Pe’er, Carmel, Pfiffner-Borges, Jenna, Pinto, Christopher J., Plaisted, Jacob, Reeves, Jason, Ross, Marty, Rudy, Melissa, Rueckert, Erroll H., Siciliano, Michelle, Sturm, Alexander, Todres, Ellen, Waghray, Avinash, Warren, Sarah, Zhang, Shuting, Zollinger, Daniel R., Cosimi, Lisa, Gupta, Rajat M., Hacohen, Nir, Hide, Winston, Price, Alkes L., Rajagopal, Jayaraj, Tata, Purushothama Rao, Riedel, Stefan, Szabo, Gyongyi, Tickle, Timothy L., Hung, Deborah, Sabeti, Pardis C., Novak, Richard, Rogers, Robert, Ingber, Donald E., Jiang, Z. Gordon, Juric, Dejan, Babadi, Mehrtash, Farhi, Samouil L., Stone, James R., Vlachos, Ioannis S., Solomon, Isaac H., Ashenberg, Orr, Porter, Caroline B.M., Li, Bo, Shalek, Alex K., Villani, Alexandra-Chloé, Rozenblatt-Rosen, Orit, Regev, Aviv
    Publicado 2021
    “…We corroborated the compositional and transcriptional changes in lung tissue through spatial analysis of RNA profiles in situ and distinguished unique tissue host responses between regions with and without viral RNA, and in COVID-19 donor tissues relative to healthy lung. …”
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    A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
  20. 54800
    “…After decreasing the level of CHD1L, RNA-seq was conducted, and the circRNA expression profiles were obtained. cirRNAs were then selected and validated by PCR together with Sanger sequencing, fluorescent in situ hybridization (FISH), and reverse transcriptase-quantitative PCR (RT-qPCR). …”
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    circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade
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