Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

por Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, Hengstler, Jan G.
Publicado 2016

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

por Chaudhari, Umesh, Nemade, Harshal, Wagh, Vilas, Gaspar, John Antonydas, Ellis, James K., Srinivasan, Sureshkumar Perumal, Spitkovski, Dimitry, Nguemo, Filomain, Louisse, Jochem, Bremer, Susanne, Hescheler, Jürgen, Keun, Hector C., Hengstler, Jan G., Sachinidis, Agapios
Publicado 2015

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

por Smirnova, L., Harris, G., Delp, J., Valadares, M., Pamies, D., Hogberg, H. T., Waldmann, T., Leist, M., Hartung, T.
Publicado 2015

Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium

por Fischer, Bettina Maria, Neumann, Daniel, Piberger, Ann Liza, Risnes, Sarah Fremgaard, Köberle, Beate, Hartwig, Andrea
Publicado 2015

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

por Colaianna, Marilena, Ilmjärv, Sten, Peterson, Hedi, Kern, Ilse, Julien, Stephanie, Baquié, Mathurin, Pallocca, Giorgia, Bosgra, Sieto, Sachinidis, Agapios, Hengstler, Jan G., Leist, Marcel, Krause, Karl-Heinz
Publicado 2016

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants

por Hirsch, Cordula, Striegl, Britta, Mathes, Stephanie, Adlhart, Christian, Edelmann, Michael, Bono, Epifania, Gaan, Sabyasachi, Salmeia, Khalifah A., Hoelting, Lisa, Krebs, Alice, Nyffeler, Johanna, Pape, Regina, Bürkle, Alexander, Leist, Marcel, Wick, Peter, Schildknecht, Stefan
Publicado 2016

M3 Macrophages Stop Division of Tumor Cells In Vitro and Extend Survival of Mice with Ehrlich Ascites Carcinoma

por Kalish, Sergey, Lyamina, Svetlana, Manukhina, Eugenia, Malyshev, Yuri, Raetskaya, Anastasiya, Malyshev, Igor
Publicado 2017

Phototoxicity of Liposomal Zn- and Al-phthalocyanine Against Cervical and Oral Squamous Cell Carcinoma Cells In Vitro

por Young, Jason, Yee, Michael, Kim, Hayoung, Cheung, Jennifer, Chino, Takahiro, Düzgüneş, Nejat, Konopka, Krystyna
Publicado 2016

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests

por Shinde, Vaibhav, Hoelting, Lisa, Srinivasan, Sureshkumar Perumal, Meisig, Johannes, Meganathan, Kesavan, Jagtap, Smita, Grinberg, Marianna, Liebing, Julia, Bluethgen, Nils, Rahnenführer, Jörg, Rempel, Eugen, Stoeber, Regina, Schildknecht, Stefan, Förster, Sunniva, Godoy, Patricio, van Thriel, Christoph, Gaspar, John Antonydas, Hescheler, Jürgen, Waldmann, Tanja, Hengstler, Jan G., Leist, Marcel, Sachinidis, Agapios
Publicado 2016

Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients

por Thiel, Christoph, Cordes, Henrik, Conde, Isabel, Castell, José Vicente, Blank, Lars Mathias, Kuepfer, Lars
Publicado 2016

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

por Wink, Steven, Hiemstra, Steven, Herpers, Bram, van de Water, Bob
Publicado 2016

TNF-Alpha Promotes Invasion and Metastasis via NF-Kappa B Pathway in Oral Squamous Cell Carcinoma

por Tang, Daofang, Tao, Detao, Fang, Yuan, Deng, Chao, Xu, Qing, Zhou, Jingping
Publicado 2017

Vascular Graft Impregnation with Antibiotics: The Influence of High Concentrations of Rifampin, Vancomycin, Daptomycin, and Bacteriophage Endolysin HY-133 on Viability of Vascular...

por Herten, Monika, Idelevich, Evgeny A., Sielker, Sonja, Becker, Karsten, Scherzinger, Anna S., Osada, Nani, Torsello, Giovanni B., Bisdas, Theodosios
Publicado 2017

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

por Proctor, William R., Foster, Alison J., Vogt, Jennifer, Summers, Claire, Middleton, Brian, Pilling, Mark A., Shienson, Daniel, Kijanska, Monika, Ströbel, Simon, Kelm, Jens M., Morgan, Paul, Messner, Simon, Williams, Dominic
Publicado 2017

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta

por Pallocca, Giorgia, Nyffeler, Johanna, Dolde, Xenia, Grinberg, Marianna, Gstraunthaler, Gerhard, Waldmann, Tanja, Rahnenführer, Jörg, Sachinidis, Agapios, Leist, Marcel
Publicado 2017

Rat precision-cut liver slices predict drug-induced cholestatic injury

por Starokozhko, Viktoriia, Greupink, Rick, van de Broek, Petra, Soliman, Nashwa, Ghimire, Samiksha, de Graaf, Inge A. M., Groothuis, Geny M. M.
Publicado 2017

Targeting Overexpressed Activating Transcription Factor 1 (ATF1) Inhibits Proliferation and Migration and Enhances Sensitivity to Paclitaxel in Esophageal Cancer Cells

por Hao, Qianyun, Zhao, Xuesong, Zhang, Yi, Dong, Ziming, Hu, Tao, Chen, Ping
Publicado 2017

Tissue Engineered Small Vessel Conduits – The Anti-Thrombotic Effect of Re-Endothelialization of Decellularized Baboon Arteries: A Preliminary Experimental Study

por Meiring, Muriel, Khemisi, Mmakgabu, Laker, Leana, Dohmen, Pascal M., Smit, Francis E.
Publicado 2017

Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells

por Lucendo-Villarin, Baltasar, Filis, Panagiotis, Swortwood, Madeleine J., Huestis, Marilyn A., Meseguer-Ripolles, Jose, Cameron, Kate, Iredale, John P., O’Shaughnessy, Peter J., Fowler, Paul A., Hay, David C.
Publicado 2017

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes

por Chaudhari, Umesh, Nemade, Harshal, Sureshkumar, Poornima, Vinken, Mathieu, Ates, Gamze, Rogiers, Vera, Hescheler, Jürgen, Hengstler, Jan Georg, Sachinidis, Agapios
Publicado 2017