Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity

por Reffatto, V., Rasinger, J. D., Carroll, T. S., Ganay, T., Lundebye, A.-K., Sekler, I., Hershfinkel, M., Hogstrand, C.
Publicado 2017

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

por Nemade, Harshal, Chaudhari, Umesh, Acharya, Aviseka, Hescheler, Jürgen, Hengstler, Jan Georg, Papadopoulos, Symeon, Sachinidis, Agapios
Publicado 2018

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

por Wink, Steven, Hiemstra, Steven W., Huppelschoten, Suzanne, Klip, Janna E., van de Water, Bob
Publicado 2018

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

por Piao, Mei Jing, Ahn, Mee Jung, Kang, Kyoung Ah, Ryu, Yea Seong, Hyun, Yu Jae, Shilnikova, Kristina, Zhen, Ao Xuan, Jeong, Jin Woo, Choi, Yung Hyun, Kang, Hee Kyoung, Koh, Young Sang, Hyun, Jin Won
Publicado 2018

Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence

por Lee, Jia-Ying Joey, Miller, James Alastair, Basu, Sreetama, Kee, Ting-Zhen Vanessa, Loo, Lit-Hsin
Publicado 2018

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

por Harris, Georgina, Eschment, Melanie, Orozco, Sebastian Perez, McCaffery, J. Michael, Maclennan, Richard, Severin, Daniel, Leist, Marcel, Kleensang, Andre, Pamies, David, Maertens, Alexandra, Hogberg, Helena T., Freeman, Dana, Kirkwood, Alfredo, Hartung, Thomas, Smirnova, Lena
Publicado 2018

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

por Karhu, S. Tuuli, Välimäki, Mika J., Jumppanen, Mikael, Kinnunen, Sini M., Pohjolainen, Lotta, Leigh, Robert S., Auno, Samuli, Földes, Gábor, Boije af Gennäs, Gustav, Yli-Kauhaluoma, Jari, Ruskoaho, Heikki, Talman, Virpi
Publicado 2018

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

por Rashidi, Hassan, Luu, Nguyet-Thin, Alwahsh, Salamah M., Ginai, Maaria, Alhaque, Sharmin, Dong, Hua, Tomaz, Rute A., Vernay, Bertrand, Vigneswara, Vasanthy, Hallett, John M., Chandrashekran, Anil, Dhawan, Anil, Vallier, Ludovic, Bradley, Mark, Callanan, Anthony, Forbes, Stuart J., Newsome, Philip N., Hay, David C.
Publicado 2018

MicroRNA-32 Regulates Development and Progression of Hepatocellular Carcinoma by Targeting ADAMTS9 and Affects Its Prognosis

por Li, Shengmian, Li, Tingting, Li, Xiaoming, Yao, Yue, Jiang, Xiaojia, Zhao, Lianmei, Guo, Wei
Publicado 2018

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

por Gutbier, Simon, May, Patrick, Berthelot, Sylvie, Krishna, Abhimanyu, Trefzer, Timo, Behbehani, Mehri, Efremova, Liudmila, Delp, Johannes, Gstraunthaler, Gerhard, Waldmann, Tanja, Leist, Marcel
Publicado 2018

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

por Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., Park, B. Kevin
Publicado 2018

Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen

por Windt, Tímea, Tóth, Szilárd, Patik, Izabel, Sessler, Judit, Kucsma, Nóra, Szepesi, Áron, Zdrazil, Barbara, Özvegy-Laczka, Csilla, Szakács, Gergely
Publicado 2019

Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity

por Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus
Publicado 2020

TatS: a novel in vitro tattooed human skin model for improved pigment toxicology research

por Hering, Henrik, Zoschke, Christian, Kühn, Markus, Gadicherla, Ashish K., Weindl, Günther, Luch, Andreas, Schreiver, Ines
Publicado 2020

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

por Krebs, Alice, van Vugt-Lussenburg, Barbara M. A., Waldmann, Tanja, Albrecht, Wiebke, Boei, Jan, ter Braak, Bas, Brajnik, Maja, Braunbeck, Thomas, Brecklinghaus, Tim, Busquet, Francois, Dinnyes, Andras, Dokler, Joh, Dolde, Xenia, Exner, Thomas E., Fisher, Ciarán, Fluri, David, Forsby, Anna, Hengstler, Jan G., Holzer, Anna-Katharina, Janstova, Zofia, Jennings, Paul, Kisitu, Jaffar, Kobolak, Julianna, Kumar, Manoj, Limonciel, Alice, Lundqvist, Jessica, Mihalik, Balázs, Moritz, Wolfgang, Pallocca, Giorgia, Ulloa, Andrea Paola Cediel, Pastor, Manuel, Rovida, Costanza, Sarkans, Ugis, Schimming, Johannes P., Schmidt, Bela Z., Stöber, Regina, Strassfeld, Tobias, van de Water, Bob, Wilmes, Anja, van der Burg, Bart, Verfaillie, Catherine M., von Hellfeld, Rebecca, Vrieling, Harry, Vrijenhoek, Nanette G., Leist, Marcel
Publicado 2020

Potentials and pitfalls of transient in vitro reporter bioassays: interference by vector geometry and cytotoxicity in recombinant zebrafish cell lines

por Lungu-Mitea, Sebastian, Lundqvist, Johan
Publicado 2020

Microbially competent 3D skin: a test system that reveals insight into host–microbe interactions and their potential toxicological impact

por Lemoine, Lisa, Dieckmann, Ralf, Al Dahouk, Sascha, Vincze, Szilvia, Luch, Andreas, Tralau, Tewes
Publicado 2020

A novel human pluripotent stem cell-based assay to predict developmental toxicity

por Lauschke, Karin, Rosenmai, Anna Kjerstine, Meiser, Ina, Neubauer, Julia Christiane, Schmidt, Katharina, Rasmussen, Mikkel Aabech, Holst, Bjørn, Taxvig, Camilla, Emnéus, Jenny Katarina, Vinggaard, Anne Marie
Publicado 2020

Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics

por Kasteel, Emma E. J., Nijmeijer, Sandra M., Darney, Keyvin, Lautz, Leonie S., Dorne, Jean Lou C. M., Kramer, Nynke I., Westerink, Remco H. S.
Publicado 2020

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

por Delp, Johannes, Cediel-Ulloa, Andrea, Suciu, Ilinca, Kranaster, Petra, van Vugt-Lussenburg, Barbara MA, Munic Kos, Vesna, van der Stel, Wanda, Carta, Giada, Bennekou, Susanne Hougaard, Jennings, Paul, van de Water, Bob, Forsby, Anna, Leist, Marcel
Publicado 2021