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201por Annunziato, Giannamaria, Spadini, Costanza, Marchetti, Marialaura, Franko, Nina, Pavone, Marialaura, Iannarelli, Mattia, Bruno, Agostino, Pieroni, Marco, Bettati, Stefano, Cabassi, Clotilde Silvia, Campanini, Barbara, Costantino, Gabriele“…Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that O-acetylserine sulfhydrylase (OASS) inhibitors could be used as colistin adjuvants to treat infections caused by critical pathogens spreading worldwide, Escherichia coli, Salmonella enterica serovar Typhimurium, and Klebsiella pneumoniae. …”
Publicado 2022
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202por Noh, Jin-Won, Cheon, Jooyoung, Kim, Kyoung-Beom, Song, Si Eun, Cha, Jiho, Kwon, Young Dae“…Due to political conflict, insurgency, and the COVID-19, the number of displaced households in need of humanitarian support in Iraq has increased. …”
Publicado 2022
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203por Listro, Roberta, Malacrida, Alessio, Ambrosio, Francesca Alessandra, Rossino, Giacomo, Di Giacomo, Marcello, Cavalloro, Valeria, Garbagnoli, Martina, Linciano, Pasquale, Rossi, Daniela, Cavaletti, Guido, Costa, Giosuè, Alcaro, Stefano, Miloso, Mariarosaria, Collina, Simona“…The insurgence of drug resistance in treating Multiple Myeloma (MM) still represents a major hamper in finding effective treatments, although over the past decades new classes of drugs, such as proteasome inhibitors and immunomodulatory drugs, have been discovered. …”
Publicado 2022
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204por Levi Mortera, Stefano, Marzano, Valeria, Vernocchi, Pamela, Matteoli, Maria Cristina, Guarrasi, Valerio, Gardini, Simone, Del Chierico, Federica, Rapini, Novella, Deodati, Annalisa, Fierabracci, Alessandra, Cianfarani, Stefano, Putignani, Lorenza“…Evidence on the correlation between the human gut microbiota (GM) composition and T1D insurgence has been recently reported. In particular, 16S rRNA-based metagenomics has been intensively employed in the last decade in a number of investigations focused on GM representation in relation to a pre-disease state or to a response to clinical treatments. …”
Publicado 2022
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205“…Several microbial species and their metabolites facilitate PCa insurgence through genotoxin-mediated mutagenesis or by driving tumor-promoting inflammation and dysfunctional immunosurveillance. …”
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206por Masuri, Sebastiano, Era, Benedetta, Pintus, Francesca, Cadoni, Enzo, Cabiddu, Maria Grazia, Fais, Antonella, Pivetta, Tiziana“…The design of novel antityrosinase agents appears extremely important in medical and industrial sectors because an irregular production of melanin is related to the insurgence of several skin-related disorders (e.g., melanoma) and the browning process of fruits and vegetables. …”
Publicado 2023
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207por Conti, Emilia, Carlini, Noemi, Piccardi, Benedetta, Allegra Mascaro, Anna Letizia, Pavone, Francesco Saverio“…Furthermore, we observe the insurgence of blood vessel leakage and edema formation in the peri-infarct area. …”
Publicado 2023
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208por Pezzotta, Alex, Brioschi, Loredana, Carbone, Sabrina, Mazzoleni, Beatrice, Bontempi, Vittorio, Monastra, Federica, Mauri, Laura, Marozzi, Anna, Mione, Marina, Pistocchi, Anna, Viani, Paola“…Therefore, efforts have been devoted to the dissection of aberrant pathways involved in GBM insurgence and resistance in order to identify new therapeutic targets. …”
Publicado 2023
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209por Abd-Allah, Israa M., El-Housseiny, Ghadir S., Al-Agamy, Mohamed H., Radwan, Hesham H., Aboshanab, Khaled M., Hassouna, Nadia A.“…INTRODUCTION: The insurgence of antimicrobial resistance is an imminent health danger globally. …”
Publicado 2023
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210por Guzzi, Pietro Hiram, Cortese, Francesca, Mannino, Gaia Chiara, Pedace, Elisabetta, Succurro, Elena, Andreozzi, Francesco, Veltri, Pierangelo“…Variation of gene expression can be correlated to changes in T2DM comorbidities insurgence and progression. Understanding gene expression changes requires the analysis of large heterogeneous data at different scales as well as the integration of different data sources into network medicine models. …”
Publicado 2023
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211“…Due to the limited availability of antifungal drugs, their relevant side effects and considering the insurgence of drug-resistant strains, novel antifungal agents are urgently needed. …”
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212por Zaghen, Francesca, Sora, Valerio Massimo, Meroni, Gabriele, Laterza, Giulia, Martino, Piera Anna, Soggiu, Alessio, Bonizzi, Luigi, Zecconi, Alfonso“…Thanks to their genetic flexibility, several virulent and drug-resistant strains have evolved mainly due to horizontal gene transfer and insurgence of point mutations. Infections caused by the colonization of such strains are particularly problematic due to frequently occurring antibiotic resistance, particulary methicillin-resistant S. aureus (MRSA), and are characterized by increased mortality, morbidity, and hospitalization rates compared to those caused by methicillin-sensitive S. aureus (MSSA). …”
Publicado 2023
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213por Suwanvanichkij, Voravit“…Vast areas of traditional Shan homelands have been systematically depopulated by the Burmese military regime as part of its counter-insurgency policy, which also employs widespread abuses of civilians by Burmese soldiers, including rape, torture, and extrajudicial executions. …”
Publicado 2008
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214por Aguilera, Óscar, González-Sancho, José Manuel, Zazo, Sandra, Rincón, Raúl, Fernández, Agustín F., Tapia, Olga, Canals, Francesc, Morte, Beatriz, Calvanese, Vincenzo, Orgaz, José L., Niell, Núria, Aguilar, Susana, Freije, José M., Graña, Osvaldo, Pisano, David G., Borrero, Aurea, Martínez-Useros, Javier, Jiménez, Benilde, Fraga, Mario F., García-Foncillas, Jesús, López-Otín, Carlos, Lafarga, Miguel, Rojo, Federico, Muñoz, Alberto“…Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/β-catenin signaling. …”
Publicado 2015
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215por Ruscitti, Piero, Cipriani, Paola, Masedu, Francesco, Romano, Silvio, Berardicurti, Onorina, Liakouli, Vasiliki, Carubbi, Francesco, Di Benedetto, Paola, Alvaro, Saverio, Penco, Maria, Valenti, Marco, Giacomelli, Roberto“…Our analysis showed that the insurgence of both SAH and MS, during the follow up, the older age, the CVE familiarity and the lack of clinical response, were associated with a significantly increased risk to experience CVEs and to develop subclinical atherosclerosis. …”
Publicado 2017
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216por Xu, Zhaolong, Raza, Qasim, Xu, Ling, He, Xiaolan, Huang, Yihong, Yi, Jinxin, Zhang, Dayong, Shao, Hong-Bo, Ma, Hongxiang, Ali, Zulfiqar“…Plant WRKY transcription factors (TFs) are active guardians against pathogens’ insurgency, key components in developmental processes, contributors in signal transduction pathways, and regulators of diverse biotic and abiotic stress responses. …”
Publicado 2018
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217“…Several questions regarding the comorbidity between these two disorders are still unanswered. If the insurgence of RLS/WED may precede the onset of PD, or if RLS/WED could represent a secondary condition of PD and if impaired dopaminergic pathway may represent a bridge between these two conditions are still debatable issues. …”
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218por Nkwogu, Loveday, Shuaib, Faisal, Braka, Fiona, Mkanda, Pascal, Banda, Richard, Korir, Charles, Bawa, Samuel, Mele, Sule, Saidu, Mahmud, Mshelia, Hyelni, Shettima, Aliyu, Tegegne, Sisay G., Yehualashet, Yared G., Adamu, Usman, Nsubuga, Peter, Vaz, Rui G., Wondimagegnehu, Alemu“…BACKGROUND: Nigeria was polio free for almost 2 years but, with the recent liberation of areas under the captivity of insurgents, there has been a resurgence of polio cases. …”
Publicado 2018
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219por Smaldone, Giovanni, Balasco, Nicole, Pirone, Luciano, Caruso, Daniela, Di Gaetano, Sonia, Pedone, Emilia Maria, Vitagliano, Luigi“…Genetic analyses have shown that the disease is caused by missense mutations of the KCTD1 protein, although the functional/structural basis of SEN insurgence is hitherto unknown. With the aim of unravelling the molecular basis of the SEN syndrome associated with KCTD1 mutations we here expressed and characterized several disease causing mutants. …”
Publicado 2019
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220por Pirrello, Carlotta, Mizzotti, Chiara, Tomazetti, Tiago C., Colombo, Monica, Bettinelli, Paola, Prodorutti, Daniele, Peressotti, Elisa, Zulini, Luca, Stefanini, Marco, Angeli, Gino, Masiero, Simona, Welter, Leocir J., Hausmann, Ludger, Vezzulli, Silvia“…We also aim to provide a survey on methods for phenotyping disease symptoms in fields, greenhouse and lab conditions, and for disease control underlying the insurgence of pathogen resistance to fungicide. Thus, we discuss fungal genetic variability, highlighting the usage and development of molecular markers and barcoding, coupled with genome sequencing. …”
Publicado 2019
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