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42341por Wadensten, Towe, Nyström, Emma, Franzén, Karin, Lindam, Anna, Wasteson, Elisabet, Samuelsson, Eva“…Cure was defined as no leakages per the bladder diary. Intention-to-treat analysis was performed. RESULTS: Between April 2017 and March 2018, 123 women (mean age 58.3, SD 9.6 years) were randomized to the treatment (n=60, 2 lost to follow-up) or information (n=63) group. …”
Publicado 2021
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42342por Mollan, Susan P., Mitchell, James L., Ottridge, Ryan S., Aguiar, Magda, Yiangou, Andreas, Alimajstorovic, Zerin, Cartwright, David M., Grech, Olivia, Lavery, Gareth G., Westgate, Connar S. J., Vijay, Vivek, Scotton, William, Wakerley, Ben R., Matthews, Tim D., Ansons, Alec, Hickman, Simon J., Benzimra, James, Rick, Caroline, Singhal, Rishi, Tahrani, Abd A., Brock, Kristian, Frew, Emma, Sinclair, Alexandra J.“…MAIN OUTCOMES AND MEASURES: The primary outcome was change in intracranial pressure measured by lumbar puncture opening pressure at 12 months, as assessed in an intention-to-treat analysis. Secondary outcomes included lumbar puncture opening pressure at 24 months as well as visual acuity, contrast sensitivity, perimetric mean deviation, and quality of life (measured by the 36-item Short Form Health Survey) at 12 and 24 months. …”
Publicado 2021
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42343por Peek, Jenny, Hay, Karen, Hughes, Pauline, Kostellar, Adrienne, Kumar, Subodh, Bhikoo, Zaheerodin, Serginson, John, Marshall, Henry M“…Motivation to quit was significantly higher in the intervention arm compared with the control arm (median 6 [IQR 4-8] versus 4 [IQR 4-5], respectively, P=.02). According to the intention-to-treat analysis, smoking abstinence was nonsignificantly higher in the intervention group (4/31 [13%], 95% CI 4%-30%, versus 2/33 [6%], 95% CI 1%-20%; P=.42). …”
Publicado 2021
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42344por Fox, Claudia K, Rudser, Kyle, Clark, Justin, Ryder, Justin R, Gross, Amy C, Nathan, Brandon M, Sunni, Muna, Dengel, Donald R, Billington, Charles John, Bensignor, Megan O, Kelly, Aaron S“…From randomization (post-MRT) to 52-weeks, the exenatide and placebo group mean BMI increased 4.6% and 10.1%, respectively. The prespecified intention-to-treat, last observation carried forward primary analysis demonstrated a placebo-subtracted exenatide treatment effect of -4.1% (95% CI -8.6 to 0.5, p=0.078). …”
Publicado 2021
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42345por Yan, Lijing L., Gong, Enying, Gu, Wanbing, Turner, Elizabeth L., Gallis, John A., Zhou, Yun, Li, Zixiao, McCormack, Kara E., Xu, Li-Qun, Bettger, Janet P., Tang, Shenglan, Wang, Yilong, Oldenburg, Brian“…Analyses were conducted in the intention-to-treat framework at the individual level with clusters and stratified design accounted for by following the prepublished statistical analysis plan. …”
Publicado 2021
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42346por Molnar, Amber O., Harvey, Andrea, Walsh, Michael, Jain, Arsh K., Bosch, Eric, Brimble, K. Scott“…All analyses were performed blinded using an intention to treat approach. We estimated the effect of the ICHA on the odds of the primary outcome using unadjusted logistic regression models. …”
Publicado 2021
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42347por Menon, Usha, Gentry-Maharaj, Aleksandra, Burnell, Matthew, Singh, Naveena, Ryan, Andy, Karpinskyj, Chloe, Carlino, Giulia, Taylor, Julie, Massingham, Susan K, Raikou, Maria, Kalsi, Jatinderpal K, Woolas, Robert, Manchanda, Ranjit, Arora, Rupali, Casey, Laura, Dawnay, Anne, Dobbs, Stephen, Leeson, Simon, Mould, Tim, Seif, Mourad W, Sharma, Aarti, Williamson, Karin, Liu, Yiling, Fallowfield, Lesley, McGuire, Alistair J, Campbell, Stuart, Skates, Steven J, Jacobs, Ian J, Parmar, Mahesh“…The primary outcome was death due to ovarian or tubal cancer (WHO 2014 criteria) by June 30, 2020. Analyses were by intention to screen, comparing MMS and USS separately with no screening using the versatile test. …”
Publicado 2021
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42348por Dijkstra, Madelon, Nieuwenhuizen, Sanne, Puijk, Robbert S., Timmer, Florentine E.F., Geboers, Bart, Schouten, Evelien A.C., Opperman, Jip, Scheffer, Hester J., de Vries, Jan J.J., Swijnenburg, Rutger-Jan, Versteeg, Kathelijn S., Lissenberg-Witte, Birgit I., van den Tol, M. Petrousjka, Meijerink, Martijn R.“…SIMPLE SUMMARY: Between 64 and 85% of patients with colorectal liver metastases (CRLM) develop distant intrahepatic recurrence after curative intent local treatment. The current standard of care for new CRLM is repeat local treatment, comprising partial hepatectomy and thermal ablation. …”
Publicado 2021
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42349por Metwally, Mostafa, Chatters, Robin, Dimairo, Munya, Walters, Stephen, Pye, Clare, White, David, Bhide, Priya, Chater, Tim, Cheong, Ying, Choudhary, Meenakshi, Child, Tim, Drakeley, Andrew, Evbuomwan, Isaac, Gelbaya, Tarek, Grace, Jan, Harris, Philip, Laird, Susan, da Silva, Sarah Martins, Mohiyiddeen, Lamiya, Pemberton, Kirsty, Raine-Fenning, Nick, Rajkhowa, Madhurima, Young, Tracey, Cohen, Judith“…MAIN RESULTS AND THE ROLE OF CHANCE: In total, 1048 women randomised to TAU (n = 525) and ES (n = 523) were available for intention to treat analysis. In the ES group, 453 (86.6%) received the ES procedure. …”
Publicado 2021
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42350por Xiang, Henry, Shen, Jiabin, Wheeler, Krista K., Patterson, Jeremy, Lever, Kimberly, Armstrong, Megan, Shi, Junxin, Thakkar, Rajan K., Groner, Jonathan I., Noffsinger, Dana, Giles, Sheila A., Fabia, Renata B.“…Speaking English as their primary language was an inclusion criterion. Intention-to-treat data analyses were conducted from December 2019 to March 2020. …”
Publicado 2021
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42351por van den Berge, Maarten, De Backer, Jan, Van Holsbeke, Cedric, De Backer, Wilfried, Trivedi, Roopa, Jenkins, Martin, Dorinsky, Paul, Aurivillius, Magnus“…RESULTS: A total of 23 patients were randomized and included in the intent-to-treat analysis (mean age 64.9 years, 78.3% males, 43.5% current smokers, mean predicted post-bronchodilator forced expiratory volume in 1 s [FEV(1)] 63.6%). …”
Publicado 2021
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42352“…A two-sample test of proportion and log-binomial regression analyses were used to compare the outcomes between the study groups. A modified intention-to-treat analysis approach was applied and a one-tailed test was reported, considering the superiority design of the trial. …”
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42353por Ehde, Dawn M., Roberts, Michelle K., Humbert, Andrew T., Herring, Tracy E., Alschuler, Kevin N.“…METHODS: Adults with MS living in the United States (N = 359) completed two online surveys (the first between 10 April 2020 and 06 May 2020; the second between 11 January 2021 and 08 February 2021) about their willingness and intent to obtain a COVID-19 vaccine. Participants also completed measures to assess factors potentially related to vaccine hesitancy, including demographics, MS variables, influenza vaccine history, vaccine concerns, and contextual factors, including perceived risk for SARS-CoV-2 infection, trust in COVID-19 information source, anxiety, and loneliness. …”
Publicado 2021
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42354por Bi, Zhao, Chen, Jia-Jian, Liu, Peng-Chen, Chen, Peng, Wang, Wei-Li, Liu, Yan-Bing, Wang, Chun-Jian, Qiu, Peng-Fei, Lv, Qing, Wu, Jiong, Wang, Yong-Sheng“…The first results from RxPONDER trial suggested that Oncotype DX could be applied to patients with 1-2 positive sentinel lymph nodes (SLNs) without axillary lymph node dissection (ALND), which constituted 37.4% of the intent-to-treat population. However, there was no distinctive research on how to apply genomic tests precisely to HR+/HER2- patients with 1-2 positive SLNs without ALND. …”
Publicado 2021
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42355por Ashburn, Kim, Chouraya, Caspian, Khumalo, Philisiwe, Mpango, Lydia, Mthethwa, Nobuhle, Machekano, Rhoderick, Guay, Laura, Mofenson, Lynne M.“…In the first analysis, all children with missing viral outcome data were excluded from the analysis (modified intent to treat, mITT). The second analysis used inverse probability of missingness weighted logistic regression to estimate the effect of FCCM on 12-month viral outcomes compared to SOC (weighted mITT). …”
Publicado 2021
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42356por Richards, Julie E, Simon, Gregory E, Boggs, Jennifer M, Beidas, Rinad, Yarborough, Bobbi Jo H, Coleman, Karen J, Sterling, Stacy A, Beck, Arne, Flores, Jean P, Bruschke, Cambria, Goldstein Grumet, Julie, Stewart, Christine C, Schoenbaum, Michael, Westphal, Joslyn, Ahmedani, Brian K“…METHODS: Using a key informant interview guide and data collection template, researchers who were embedded in each health care system cataloged and summarized current and future practices supporting ZS, including, (1) the function addressed; (2) a description of practice intent and mechanism of intervention; (3) the target patient population and service setting; (4) when/how the practice was (or will be) implemented; and (5) whether/how the practice was documented and/or measured. …”
Publicado 2021
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42357por Horn, Leora, Wang, Ziping, Wu, Gang, Poddubskaya, Elena, Mok, Tony, Reck, Martin, Wakelee, Heather, Chiappori, Alberto A., Lee, Dae Ho, Breder, Valeriy, Orlov, Sergey, Cicin, Irfan, Cheng, Ying, Liu, Yunpeng, Fan, Yun, Whisenant, Jennifer G., Zhou, Yi, Oertel, Vance, Harrow, Kim, Liang, Chris, Mao, Li, Selvaggi, Giovanni, Wu, Yi-Long“…Efficacy was evaluated in the intent-to-treat (ITT) population as well as a prespecified modified ITT (mITT) population consisting of patients with central laboratory–confirmed ALK-positive NSCLC. …”
Publicado 2021
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42358“…RESULTS: Ninety colorectal cancer resections were performed with curative intent from June 2018 to June 2020. Thirty robotic colorectal cancer resections (RCcR) were performed after adaption of programme and were compared with 60 non-robotic colorectal cancer resections (N-RCcR) prior to implementation of technique. …”
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42359por Keum, Jiyoung, Chung, Moon Jae, Kim, Youngin, Ko, Hyunyoung, Sung, Min Je, Jo, Jung Hyun, Park, Jeong Youp, Bang, Seungmin, Park, Seung Woo, Song, Si Young, Lee, Hee Seung“…The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) and the Patient-Generated Subjective Global Assessment (PG-SGA) were used as paper questionnaires to assess the QoL and nutritional status of the patients. Intention-to-treat and per-protocol analyses were conducted. …”
Publicado 2021
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42360por Hollis, Chris, Hall, Charlotte L, Jones, Rebecca, Marston, Louise, Novere, Marie Le, Hunter, Rachael, Brown, Beverley J, Sanderson, Charlotte, Andrén, Per, Bennett, Sophie D, Chamberlain, Liam R, Davies, E Bethan, Evans, Amber, Kouzoupi, Natalia, McKenzie, Caitlin, Heyman, Isobel, Khan, Kareem, Kilgariff, Joseph, Glazebrook, Cristine, Mataix-Cols, David, Murphy, Tara, Serlachius, Eva, Murray, Elizabeth“…Safety analysis was by intention to treat. Longer term follow-up is ongoing. …”
Publicado 2021
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