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  1. 42361
    “…The primary analysis of OS followed the intent-to-treat principle. Other secondary end points included objective response rate, safety and tolerability, and quality of life. …”
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    Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial
  2. 42362
    “…Data were collected from September 2020 to February 2021 and analyzed using intention-to-treat analysis. The analytic data set included participants (18/101, 17.8% clinic patients; 83/101, 82.1% community) who completed at least one study survey: ER (50/101, 49.5%) and WLC (51/104, 49%). …”
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    Efficacy of a Single-Session “Empowered Relief” Zoom-Delivered Group Intervention for Chronic Pain: Randomized Controlled Trial Conducted During the COVID-19 Pandemic
  3. 42363
    “…Methods: The protocol-based, international IMIGASTRIC (International study group on Minimally Invasive surgery for Gastric Cancer) registry was queried to retrieve data on patients undergoing laparoscopic or open gastrectomy with D2 lymphadenectomy for gastric cancer with curative intent from January 2000 to December 2014. Eleven predefined, demographical, clinical, and pathological variables were used to conduct a 1:1 propensity score matching (PSM) analysis to investigate intraoperative and recovery outcomes, complications, pathological findings, and survival data between the two groups. …”
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    Laparoscopic Compared with Open D2 Gastrectomy on Perioperative and Long-Term, Stage-Stratified Oncological Outcomes for Gastric Cancer: A Propensity Score-Matched Analysis of the IMIGASTRIC Database
  4. 42364
    “…Primary analysis was by intention-to-treat with NMR and post-24-hour NMR as the primary outcomes. …”
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    Effect of sunflower seed oil emollient therapy on newborn infant survival in Uttar Pradesh, India: A community-based, cluster randomized, open-label controlled trial
  5. 42365
    “…BACKGROUND: Over a million adolescents die globally each year from preventable or treatable causes, with injuries (intentional and unintentional) being the leading cause of these deaths. …”
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    The relationship between psychosocial circumstances and injuries in adolescents: An analysis of 87,269 individuals from 26 countries using the Global School-based Student Health Survey
  6. 42366
    “…Interestingly, there was a paradoxical increase in the number of intentional interpersonal injuries [1]. In fact, the number of domestic assault cases grew by at least 5% during this time at the national level [2]. …”
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    How has the COVID-19 Pandemic Impacted the Clinical Volume and Variety of an Academic Oral and Maxillofacial Surgery Program?
  7. 42367
    “…We reviewed medical records and collected clinicopathologic factors for OPC patients treated with curative intent RT. The Kaplan-Meier method was used to estimate time-to-event outcomes. …”
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    Oropharyngeal Cancer Early Outcomes and Challenges During the COVID-19 Pandemic
  8. 42368
    “…From 3/1/2020-1/29/2021, mean age was 4.9 y (range 5.5 m - 19.0 y), 41/78 (52.6%) were male, and 2/78 (2.6%) received 2 courses of RT under GA, for a total of 80 courses. 24/80 (30.0%) courses were delivered to the chest, abdomen, and/or pelvis, 21/80 (26.3%) craniospinal axis, 17/80 (21.3%) brain, 9/80 (11.3%) total body irradiation, 5/80 (6.3%) head/neck, and 4/80 (5%) other. 64/80 (80%) of courses were delivered with curative intent. 39/80 (48.8%) used proton therapy, 18/80 (22.5%) photons, and 23/80 (28.8%) both modalities. …”
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    General Anesthesia for Pediatric Radiotherapy in the Era of COVID-19
  9. 42369
    “…RESULTS: A total of 671 patients were included in the intent-to-treat population. The ratio of ORR was 0.96 [confidence interval (CI) 0.83, 1.12] and the difference in ORR was −1.6 (CI −9.0, 5.9) between treatment arms; CIs were within the predefined equivalence margins. …”
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    Phase III double-blind study comparing the efficacy and safety of proposed biosimilar MYL-1402O and reference bevacizumab in stage IV non-small-cell lung cancer
  10. 42370
    “…Summary of Dosing and Pharmacokinetic Sampling Schedule by Age Cohort [Image: see text] RESULTS: A total of 94 participants were randomized 3:1; 91 were treated with C/T + MTZ (n=70) or MEM (n=21) comprising the modified intent-to-treat (MITT) population. The clinically evaluable population included 78 participants at EOT (C/T + MTZ, n=59; MEM, n=19) and 77 participants at TOC (C/T + MTZ, n=58; MEM, n=19). …”
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    1154. Safety and Efficacy of Ceftolozane/Tazobactam Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-abdominal Infection: A Phase 2, Randomized Clinical Trial
  11. 42371
    “…The microbiologic modified intent-to-treat population (mMITT) included 95 participants in the C/T (n=71) and MEM (n=24) arms; the most common reason for mMITT exclusion was lack of a qualifying baseline uropathogen (28.4%). …”
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    1143. Safety and Efficacy of Ceftolozane/Tazobactam Versus Meropenem in Neonatal and Pediatric Participants With Complicated Urinary Tract Infection, Including Pyelonephritis: A Phase 2, Randomized, Clinical Trial
  12. 42372
    “…Median age was 55 years (range 16 to 97), and most were female (74%). Intention to receive a COVID-19 vaccine increased from 59% to 80% after using Corowa-kun (p < 0.01). …”
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    439. Corowa-kun: Impact of a COVID-19 Vaccine Information Chatbot on Vaccine Hesitancy, Japan 2021
  13. 42373
    “…Participants rated CORE as highly usable and acceptable. Intent-to-treat analyses showed significant treatment×time interactions for the BDI-II (F(1,313)=13.38; P<.001), GAD-7 (F(1,313)=5.87; P=.01), RAS (F(1,313)=23.42; P<.001), RSES (F(1,313)=19.28; P<.001), and SDS (F(1,313)=10.73; P=.001). …”
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    A Smartphone Intervention for People With Serious Mental Illness: Fully Remote Randomized Controlled Trial of CORE
  14. 42374
    “…Linear mixed models provided intention-to-treat analyses, with linear and quadratic effects for time and random intercepts for participants and couples. …”
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    The Baby Steps Web Program for the Well-Being of New Parents: Randomized Controlled Trial
  15. 42375
    “…Analysis was performed on an intention-to-treat basis. INTERVENTIONS: From a list of 11 values, intervention patients wrote about their most important values and control patients wrote about their least important values. …”
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    Effect of Values Affirmation on Reducing Racial Differences in Adherence to Hypertension Medication: The HYVALUE Randomized Clinical Trial
  16. 42376
    “…No differences were observed in the intention-to-treat analysis in the primary outcome, total PANSS score at 6 months (mean difference, 3.57; 95% CI, −1.11 to 8.25; P = .13), or the secondary outcomes at 3 and 6 months (PANSS positive subscore: mean difference, −0.98; 95% CI, −2.23 to 0.27 at 3 months; mean difference, 0.68; 95% CI, −0.69 to 1.99 at 6 months; PANSS negative subscore: mean difference, 0.68; 95% CI, −1.39 to 2.76 at 3 months; mean difference, 1.56; 95% CI, −0.31 to 3.44 at 6 months; and general psychopathology subscore: mean difference, −2.09; 95% CI, −4.36 to 0.18 at 3 months; mean difference, 1.31; 95% CI, −1.42 to 4.05 at 6 months). …”
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    Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis: The DFEND Randomized Clinical Trial
  17. 42377
    “…Repeated-measures and log rank analyses were used in an intention-to-treat approach. RESULTS: Among 500 participants, the mean (SD) age was 73.0 (8.2) years; 314 participants (62.8%) were men. …”
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    Long-term Effectiveness of Adjuvant Treatment With Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared With Dopamine Agonists Among Patients With Parkinson Disease Uncontrolled by Levodopa Therapy: The PD MED Randomized Clinical Trial
  18. 42378
    “…A per-protocol analysis included time, NIATx fidelity, and agency focus as predictors. RESULTS: The intent-to-treat analysis found a statistically significant change in access to addiction versus neither medication, but Cohort1 compared to Cohort2 at Year 1 showed no differences. …”
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    Improving medication access within integrated treatment for individuals with co-occurring disorders in substance use treatment agencies
  19. 42379
    “…Secondary outcomes included pain intensity, quality of life, sleep quality, recommendation of intervention, and minimal clinically important difference. Intention-to-treat and per-protocol analyses were performed. …”
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    Efficacy of Therapeutic Aquatic Exercise vs Physical Therapy Modalities for Patients With Chronic Low Back Pain: A Randomized Clinical Trial
  20. 42380
    “…The analysis used an intention-to-treat approach. INTERVENTIONS: Participants were randomized to receive daily oral supplementation with either 1000 mg urolithin A or placebo for 4 months. …”
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    Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
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