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42521“…LIMITATIONS, REASONS FOR CAUTION: Although the use of contraceptive methods was already high and no change was noted, the ZIKV outbreak may have changed the pregnancy intentions of Brazilian women. Consequently, the number of women planning pregnancy may be lower than that recorded. …”
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42522por Patel, Vikram, Weobong, Benedict, Weiss, Helen A, Anand, Arpita, Bhat, Bhargav, Katti, Basavraj, Dimidjian, Sona, Araya, Ricardo, Hollon, Steve D, King, Michael, Vijayakumar, Lakshmi, Park, A-La, McDaid, David, Wilson, Terry, Velleman, Richard, Kirkwood, Betty R, Fairburn, Christopher G“…Primary outcomes were depression symptom severity on the Beck Depression Inventory version II and remission from depression (PHQ-9 score of <10) at 3 months in the intention-to-treat population, assessed by masked field researchers. …”
Publicado 2017
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42523por Glynne-Jones, Robert, Sebag-Montefiore, David, Meadows, Helen M, Cunningham, David, Begum, Rubina, Adab, Fawzi, Benstead, Kim, Harte, Robert J, Stewart, Jill, Beare, Sandy, Hackshaw, Allan, Kadalayil, Latha“…We analysed both the overall trial population and a subgroup of patients who had attended each of the three assessments by modified intention-to-treat. This study is registered at controlled-trials.com, ISRCTN 26715889. …”
Publicado 2017
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42524por Cunningham, David, Stenning, Sally P, Smyth, Elizabeth C, Okines, Alicia F, Allum, William H, Rowley, Sam, Stevenson, Laura, Grabsch, Heike I, Alderson, Derek, Crosby, Thomas, Griffin, S Michael, Mansoor, Wasat, Coxon, Fareeda Y, Falk, Stephen J, Darby, Suzanne, Sumpter, Kate A, Blazeby, Jane M, Langley, Ruth E“…The primary outcome for the phase 3 stage of the trial was overall survival (defined as the time from randomisation until death from any cause), analysed in the intention-to-treat population. Here, we report the primary analysis results of the trial; all patients have completed treatment and the required number of primary outcome events has been reached. …”
Publicado 2017
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42525por Orwig, D, Mangione, KK, Baumgarten, M, Terrin, M, Fortinsky, R, Kenny, AM, Gruber-Baldini, AL, Beamer, B, Tosteson, ANA, Shardell, M, Magder, L, Binder, E, Koval, K, Resnick, B, Craik, RL, Magaziner, J“…ANALYSIS: Analyses for all aims will be performed according to the intention-to-treat paradigm. Except for testing of the primary hypothesis, all statistical tests will be two-sided and not adjusted for multiple comparisons. …”
Publicado 2016
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42526por Boone, Peter, Eble, Alex, Elbourne, Diana, Frost, Chris, Jayanty, Chitra, Lakshminarayana, Rashmi, Mann, Vera, Mukherjee, Rohini, Piaggio, Gilda, Reddy, Padmanabh“…Primary analyses followed the intention to treat principle. In all, 14,137 women were enrolled in 232 control villages, and 15,532 in 232 intervention villages. …”
Publicado 2017
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42527“…Fifty eight out of the total 60 intention-to-treat (ITT) patients in the reference group achieved SVR12 (96.67% (95% confidence interval (CI): 88.64–99%). …”
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42528por Faivre-Finn, Corinne, Snee, Michael, Ashcroft, Linda, Appel, Wiebke, Barlesi, Fabrice, Bhatnagar, Adityanarayan, Bezjak, Andrea, Cardenal, Felipe, Fournel, Pierre, Harden, Susan, Le Pechoux, Cecile, McMenemin, Rhona, Mohammed, Nazia, O'Brien, Mary, Pantarotto, Jason, Surmont, Veerle, Van Meerbeeck, Jan P, Woll, Penella J, Lorigan, Paul, Blackhall, Fiona“…The primary endpoint was overall survival, defined as time from randomisation until death from any cause, analysed by modified intention-to-treat. A 12% higher overall survival at 2 years in the once-daily group versus the twice-daily group was considered to be clinically significant to show superiority of the once-daily regimen. …”
Publicado 2017
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42529por Nair, Nirmala, Tripathy, Prasanta, Sachdev, H S, Pradhan, Hemanta, Bhattacharyya, Sanghita, Gope, Rajkumar, Gagrai, Sumitra, Rath, Shibanand, Rath, Suchitra, Sinha, Rajesh, Roy, Swati Sarbani, Shewale, Suhas, Singh, Vijay, Srivastava, Aradhana, Costello, Anthony, Copas, Andrew, Skordis-Worrall, Jolene, Haghparast-Bidgoli, Hassan, Saville, Naomi, Prost, Audrey“…The primary outcome was children's length-for-age Z score at 18 months of age. Analyses were by intention to treat. Due to the nature of the intervention, participants and the intervention team were not masked to allocation. …”
Publicado 2017
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42530por Wakelee, Heather A., Dahlberg, Suzanne E., Keller, Steven M., Tester, William J., Gandara, David R., Graziano, Stephen L., Adjei, Alex, Leighl, Natasha B., Aisner, Seena C., Rothman, Jan M., Patel, Jyoti D., Sborov, Mark D., McDermott, Sean R., Perez-Soler, Roman, Traynor, Anne M., Butts, Charles, Evans, Tracey, Shafqat, Atif, Chapman, Andrew E., Kasbari, Samer S., Horn, Leora, Ramalingam, Suresh S., Schiller, Joan“…The primary endpoint was overall survival, which was defined as the time from randomisation to death from any cause, and patients who were thought to be alive at the time of final analysis were censored at the last date of contact with analysis done based on intention to treat. This is final analysis of the primary endpoint of overall survival of E1505 (NCT00324805). …”
Publicado 2017
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42531“…NVSS-M variables include decedent characteristics (sex, age, and race/ethnicity) and information on intent (unintentional, suicide, homicide, or undetermined), location of death (medical facility, in a home, or other [including nursing homes, hospices, unknown, and other locations]) and county of residence (metropolitan/nonmetropolitan). …”
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42532por de Boer, Stephanie M, Powell, Melanie E, Mileshkin, Linda, Katsaros, Dionyssios, Bessette, Paul, Haie-Meder, Christine, Ottevanger, Petronella B, Ledermann, Jonathan A, Khaw, Pearly, Colombo, Alessandro, Fyles, Anthony, Baron, Marie-Helene, Jürgenliemk-Schulz, Ina M, Kitchener, Henry C, Nijman, Hans W, Wilson, Godfrey, Brooks, Susan, Carinelli, Silvestro, Provencher, Diane, Hanzen, Chantal, Lutgens, Ludy C H W, Smit, Vincent T H B M, Singh, Naveena, Do, Viet, D'Amico, Romerai, Nout, Remi A, Feeney, Amanda, Verhoeven-Adema, Karen W, Putter, Hein, Creutzberg, Carien L“…We used the Kaplan-Meier method, log-rank test, and Cox regression analysis for final analysis by intention to treat and adjusted for stratification factors. …”
Publicado 2018
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42533“…MAIN RESULTS AND THE ROLE OF CHANCE: Amongst the 159 participants included in the intention-to-treat analysis, four women conceived before treatment and six were lost-to-follow-up. …”
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42534por Beigel, John H, Voell, Jocelyn, Kumar, Parag, Raviprakash, Kanakatte, Wu, Hua, Jiao, Jin-An, Sullivan, Eddie, Luke, Thomas, Davey, Richard T“…The primary outcome was safety, and immunogenicity was a secondary outcome. We analysed the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT02788188. …”
Publicado 2018
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42535por Cox, Sharon E, Ellins, Elizabeth A, Marealle, Alphonce I, Newton, Charles R, Soka, Deogratias, Sasi, Philip, Luca Di Tanna, Gian, Johnson, William, Makani, Julie, Prentice, Andrew M, Halcox, Julian P, Kirkham, Fenella J“…Analyses were done on the eligible intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01718054; and with ISRCTN74331412. …”
Publicado 2018
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42536por Protopopoff, Natacha, Mosha, Jacklin F, Lukole, Eliud, Charlwood, Jacques D, Wright, Alexandra, Mwalimu, Charles D, Manjurano, Alphaxard, Mosha, Franklin W, Kisinza, William, Kleinschmidt, Immo, Rowland, Mark“…FINDINGS: 7184 (68·0%) of 10 560 households were selected for post-intervention survey, and 15 469 (89·0%) of 17 377 eligible children from the four surveys were included in the intention-to-treat analysis. Of the 878 households visited in the two indoor residual spraying groups, 827 (94%) had been sprayed. …”
Publicado 2018
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42537por Mallewa, Jane, Szubert, Alexander J, Mugyenyi, Peter, Chidziva, Ennie, Thomason, Margaret J, Chepkorir, Priscilla, Abongomera, George, Baleeta, Keith, Etyang, Anthony, Warambwa, Colin, Melly, Betty, Mudzingwa, Shepherd, Kelly, Christine, Agutu, Clara, Wilkes, Helen, Nkomani, Sanele, Musiime, Victor, Lugemwa, Abbas, Pett, Sarah L, Bwakura-Dangarembizi, Mutsa, Prendergast, Andrew J, Gibb, Diana M, Walker, A Sarah, Berkley, James A“…The primary outcome was mortality at week 24, analysed by intention to treat. Secondary outcomes included absolute changes in weight, BMI, and mid-upper-arm circumference (MUAC). …”
Publicado 2018
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42538por Saville, Naomi M., Shrestha, Bhim P., Style, Sarah, Harris-Fry, Helen, Beard, B. James, Sen, Aman, Jha, Sonali, Rai, Anjana, Paudel, Vikas, Sah, Raghbendra, Paudel, Puskar, Copas, Andrew, Bhandari, Bishnu, Neupane, Rishi, Morrison, Joanna, Gram, Lu, Pulkki-Brännström, Anni-Maria, Skordis-Worrall, Jolene, Basnet, Machhindra, de Pee, Saskia, Hall, Andrew, Harthan, Jayne, Thondoo, Meelan, Klingberg, Sonja, Messick, Janice, Manandhar, Dharma S., Osrin, David, Costello, Anthony“…Only children born to permanent residents between 4 June 2014 and 20 June 2015 were eligible for intention to treat analyses (n = 10936), while in-migrating women and children born before interventions had been running for 16 weeks were excluded. …”
Publicado 2018
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42539por Prudhomme O’Meara, Wendy, Menya, Diana, Laktabai, Jeremiah, Platt, Alyssa, Saran, Indrani, Maffioli, Elisa, Kipkoech, Joseph, Mohanan, Manoj, Turner, Elizabeth L.“…Analyses followed the intention-to-treat principle using generalized estimating equations (GEEs) to account for clustering with prespecified adjustment for gender, age, education, and wealth. …”
Publicado 2018
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42540por Menant, Jasmine C., Migliaccio, Americo A., Sturnieks, Daina L., Hicks, Cameron, Lo, Joanne, Ratanapongleka, Mayna, Turner, Jessica, Delbaere, Kim, Titov, Nickolai, Meinrath, Daniela, McVeigh, Catherine, Close, Jacqueline C. T., Lord, Stephen R.“…Data from 274 participants (90%; 137 per group) were included in the intention-to-treat analysis. At trial completion, the DHI scores in the intervention group (pre and post mean [SD]: 25.9 [19.2] and 20.4 [17.7], respectively) were significantly reduced compared with the control group (pre and post mean [SD]: 23.0 [15.8] and 21.8 [16.4]), when controlling for baseline scores (mean [95% CI] difference between groups [baseline adjusted]: −3.7 [−6.2 to −1.2]; p = 0.003). …”
Publicado 2018
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