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  1. 42661
    “…Secondary outcomes included miscarriages, livebirth, adverse events, stillbirth, neonatal birth weight, changes in clinical laboratory variables following study drug exposure, major congenital anomalies, preterm births and incidence of anti-drug antibody formation. Analysis was by intention to treat. MAIN RESULTS AND THE ROLE OF CHANCE: A total of 340 participants were screened for eligibility of which 150 women were randomized. 76 women (median age, 32[IQR, 29–34] years; mean BMI, 26.3[SD, 4.2]) and 74 women (median age, 31[IQR, 26–33] years; mean BMI, 25.8[SD, 4.2]) were randomized to placebo. …”
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    Recombinant human granulocyte– colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial
  2. 42662
    “…We analysed data on an intention‐to‐treat basis using a random‐effects model. …”
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    Antiretroviral resistance testing in HIV‐positive people
  3. 42663
    “…Primary analysis was based on the modified intention-to-treat (mITT) population, which included randomly assigned patients who gave informed consent and excluded those without 6-month outcome measures. …”
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    Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS): a multicentre, single-blinded, randomised controlled trial
  4. 42664
    “…One patient in the liraglutide group withdrew consent before having received the study drug and was not included in the intention-to-treat analysis. Liraglutide (n = 23) vs placebo (n = 26) significantly reduced body weight (liraglutide 98.4 ± 13.8 kg to 94.3 ± 14.9 kg; placebo 94.5 ± 13.1 kg to 93.9 ± 13.2 kg; estimated treatment effect −4.5 [95% CI −6.4, −2.6] kg). …”
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    Placebo-controlled randomised trial with liraglutide on magnetic resonance endpoints in individuals with type 2 diabetes: a pre-specified secondary study on ectopic fat accumulation
  5. 42665
    “…All analyses (except safety) were done on the intention-to-treat population. Safety analyses included all randomly assigned patients. …”
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    Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial
  6. 42666
    “…The primary outcome was the diagnosis of Barrett's oesophagus at 12 months after enrolment, expressed as a rate per 1000 person-years, in all participants in the intervention group (regardless of whether they had accepted the offer of the Cytosponge-TFF3 procedure) compared with all participants in the usual care group. Analyses were intention-to-treat. The trial is registered with the ISRCTN registry, ISRCTN68382401, and is completed. …”
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    Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial
  7. 42667
    “…The primary analysis was done in the intention-to-treat population and safety analyses were done in all patients according to treatment received. …”
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    Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial
  8. 42668
    “…Primary outcomes were analysed by intention to treat. Safety outcomes were reported according to as-treated status, for all patients who had received at least one session of CBT or family intervention, or at least one dose of antipsychotics. …”
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    Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
  9. 42669
    “…LIMITATIONS, REASONS FOR CAUTION: We lacked direct information on the intention to conceive and the androgenic biochemical status of the PCOS participants, applying instead the use of anti-androgenic medications as a proxy of hyperandrogenism. …”
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    Early initiation of anti-androgen treatment is associated with increased probability of spontaneous conception leading to childbirth in women with polycystic ovary syndrome: a population-based multiregistry cohort study in Sweden
  10. 42670
    “…Analyses were done in the intention-to-treat population. The acceptable success rate was defined as treatment efficacy in more than 80% of patients. …”
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    Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study
  11. 42671
    “…All outcomes were analysed in the modified intention-to-treat population of all randomly assigned participants except those whose for whom consent was withdrawn. …”
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    BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial
  12. 42672
    “…The coprimary endpoints were time to first self-reported recovery, and hospitalisation or death related to COVID-19, both measured over 28 days from randomisation and analysed by intention to treat. This trial is ongoing and is registered with ISRCTN, 86534580. …”
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    Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
  13. 42673
    “…MATÉRIELS ET MÉTHODES: Chez des patient(e)s suivi(e)s pour une infection à VIH, une enquête a été réalisée prospectivement et de façon exhaustive, entre septembre et décembre 2020, avant la mise à disposition des vaccins, pour connaître les intentions de vaccination contre la COVID-19. La notion de vaccination grippale et la perception du sur-risque lié à l’infection à VIH étaient également évaluées. …”
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    Les patients infectés par le VIH sont-ils défiants vis-à-vis de la vaccination COVID-19 ?
  14. 42674
    “…Analysis was performed by both intention-to-treat and per-protocol principles. RESULTS: A total of 646 FETs were completed. …”
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    Immediate versus delayed frozen embryo transfer in women following a failed IVF-ET attempt: a multicenter randomized controlled trial
  15. 42675
    “…FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). With the intention of expediting dissemination of this trial, the conventional formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. …”
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    Anti-COVID property of subcutaneous ivermectin in synergy with zinc among midlife moderately symptomatic patients: a structured summary of a study protocol for a randomised controlled trial
  16. 42676
    “…Analyses were done on an intention-to-treat basis. Local and unsolicited systemic reactions and humoral responses were also assessed. …”
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    Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial
  17. 42677
    “…Week 144 analyses assessed non-inferiority (NI) with a 4% NI margin for Snapshot virologic failure (VF) and 8% for virologic success (VS; FDA Snapshot algorithm, intention-to-treat–exposed [ITT-E] population). RESULTS: Of 741 randomized/exposed pts (DTG/3TC: 369; TBR: 372), most pts entered the study on EVG/c (66%). …”
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    900. Switching to DTG/3TC Fixed-Dose Combination (FDC) Is Non-inferior to Continuing a TAF-Based Regimen (TBR) in Maintaining Virologic Suppression Through 144 Weeks (TANGO Study)
  18. 42678
    por Xiang, Michael, Ma, Ting Martin, Savjani, Ricky, Pollom, Erqi L., Karnes, R. Jeffrey, Grogan, Tristan, Wong, Jessica K., Motterle, Giovanni, Tosoian, Jeffrey J., Trock, Bruce J., Klein, Eric A., Stish, Bradley J., Dess, Robert T., Spratt, Daniel E., Pilar, Avinash, Reddy, Chandana, Levin-Epstein, Rebecca, Wedde, Trude B., Lilleby, Wolfgang A., Fiano, Ryan, Merrick, Gregory S., Stock, Richard G., Demanes, D. Jeffrey, Moran, Brian J., Huland, Hartwig, Tran, Phuoc T., Martin, Santiago, Martinez-Monge, Rafael, Krauss, Daniel J., Abu-Isa, Eyad I., Alam, Ridwan, Schwen, Zeyad, Pisansky, Thomas M., Choo, C. Richard, Song, Daniel Y., Greco, Stephen, Deville, Curtiland, McNutt, Todd, DeWeese, Theodore L., Ross, Ashley E., Ciezki, Jay P., Boutros, Paul C., Nickols, Nicholas G., Bhat, Prashant, Shabsovich, David, Juarez, Jesus E., Chong, Natalie, Kupelian, Patrick A., Rettig, Matthew B., Zaorsky, Nicholas G., Berlin, Alejandro, Tward, Jonathan D., Davis, Brian J., Reiter, Robert E., Steinberg, Michael L., Elashoff, David, Horwitz, Eric M., Tendulkar, Rahul D., Tilki, Derya, Czernin, Johannes, Gafita, Andrei, Romero, Tahmineh, Calais, Jeremie, Kishan, Amar U.
    Publicado 2021
    “…Data were analyzed from December 2020 to March 2021. EXPOSURES: Curative-intent radical prostatectomy (RP), external beam radiotherapy (EBRT), or EBRT plus brachytherapy (BT), with or without androgen deprivation therapy. …”
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    Performance of a Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography–Derived Risk-Stratification Tool for High-risk and Very High-risk Prostate Cancer
  19. 42679
    “…Nature of disease (slow growing vs fast growing) and the intent of treatment (cure vs control of disease) were shown to significantly affect preferences of patients. …”
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    A Prospective Survey to Understand the Preferences and Perspectives of Patients with Hematological Malignancies in a Tertiary Cancer Care Setting in India (CANCOV SURVEY)
  20. 42680
    “…Two hundred fifty-six patients (49.2%) were of Hispanic or Latino ethnicity; 275 (52.9%) had diabetes; and 248 (47.7%) were receiving statins. In the intention-to-treat analysis, TG levels were reduced by 26.0% (95% CI, 20.5%-31.5%) in the ω-3–PL/FFA group and 15.1% (95% CI, 6.6%-23.5%) in the placebo group at 12 weeks (mean treatment difference, −10.9% [95% CI, −20.4% to −1.5%]; P = .02), with reductions persisting at 26 weeks (mean treatment difference, −12.7% [95% CI, −23.1% to −2.4%]; P = .02). …”
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    Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial
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