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  1. 262941
    “…However, no typical dose-dependent positive association between type 2 diabetes mellitus incidence and the TG levels was observed across the TG tertiles. Interestingly, a U-shaped association between TG concentration and risk of incident type 2 diabetes mellitus was revealed by the two-piecewise linear regression analysis. …”
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    U-shaped association between triglyceride and risk of incident diabetes in normoglycemic males with NAFLD: A population-base cohort study
  2. 262942
    por Syeda, Asma, Kantorovich, Vitaly
    Publicado 2023
    “…Next Generation Sequencing of the surgical specimen was positive for ATM gene deletion. Interestingly, immunohistochemistry stained strongly for insulin, glucagon and INSM1 suggestive of nesidioblastosis although the patient did not have preoperative hypoglycemia that would raise a clinical suspicion. …”
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    THU521 A Case Of Multifocal Pancreatic Neuroendocrine Tumor With Multiple Twists
  3. 262943
    por Lee, Jihyun
    Publicado 2023
    “…But some express more than one single hormone, and cells containing insulin and glucagon (Ins+:Glu+ cells) are seen during prenatal pancreas development. Interestingly, Ins+:Glu+ cells have been observed in adult islets from diabetic mice or type 2 diabetes (T2D) human cadavers. …”
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    SAT067 Bone Marrow-induced Epithelial-Mesenchymal Transition In Beta Cells
  4. 262944
    “…Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have been linked with FG. Interestingly, multiple studies have found no significantly increased risk of FG with SGLT2i use. …”
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    THU282 Improved Fournier’s Gangrene Outcomes With Prior SGLT2i Or Metformin Usage
  5. 262945
    “…Other mutational characteristics such as mutational signatures and CNVs also differed, suggesting the independent subclonal evolution of the paired MT from the PTM1 after metastasis. Interestingly, the frequency of mutations including driver, TERT promoter, and other mutations was lower in primary tumors without metastases (PTM0). …”
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    THU484 Distinct Genetic Characteristics In Follicular Thyroid Cancer With Different Metastatic Potentials
  6. 262946
    por Yuen, Alexa, Owen, Randall, Saul, Shira R
    Publicado 2023
    “…Post-operatively, she received 100 millicurie of radioactive iodine and was started on levothyroxine. Interestingly, the patient reported as strong family history of varying cancers, notably colon, breast, uterine, and thyroid. …”
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    SAT512 Familial Thyroid Cancer With Negative Pre-operative Genetic Screening
  7. 262947
    “…We observed MDA-MD-231 cells had a 50% reduction of estradiol from 160 ng/ml to 100 ng/ml following stress for 45 minutes. Interestingly MDA-MD-231-AIPB cells synthesized only 62 ng/ml, which is an 18.75% reduction. …”
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    THU555 Stress Induced AIPB Expression In Triple Negative (ER-/PR-/Her2-) Breast Tumors Reduces Estradiol
  8. 262948
    “…In prostate cancer (PCa), CYR61 contributes to cell growth and survival through its interactions with extracellular ligands, such as integrins avb3 and a6b4, in the extracellular matrix space. Interestingly, CYR61 contains an insulin-like growth factor-binding protein domain suggesting that it may interact with insulin-like growth factor-1 (IGF1). …”
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    THU502 CYR61, A Member Of The CCN Protein Family, Regulates IGF1 In Metastatic Prostate Cancer
  9. 262949
    “…Lack of symptom improvement despite two courses of antibiotics and A1c over 11% raised clinical suspicion of IFS . Interestingly frozen path did not reveal hyphae that led to her first discharge from hospital. …”
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    THU355 Tingling Over Cheek, An Atypical Presentation Of Invasive Fungal Sinusitis In An Ambulatory Patient With Type 2 Diabetes
  10. 262950
    “…It is well-known that bone fragility is the hallmark feature of osteogenesis imperfecta. Interestingly, other HCTDs, including Ehlers-Danlos syndrome (EDS), Marfan’s syndrome (MFS) and Loeys-Dietz syndrome (LDS) are shown to be associated with bone fragility. …”
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    THU411 Fracture And Osteoporosis In Hereditary Connective Tissue Disorders: A Systematic Review And Meta-analysis
  11. 262951
    “…Wild-type mice, when challenged with WD supplemented with fiber, were protected from this effect with only a mild increase in body weight and insulin resistance. Interestingly, F2,3-dKO mice, fed WD + 20% FOS were insensitive to fiber induced metabolic benefits. …”
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    FRI013 Free Fatty Acid Receptors 2 And 3 Mediate The Beneficial Effects Of Fiber
  12. 262952
    “…This explained her intermittent hypotension along with mental and behavioral changes. Interestingly, she was found to be on megestrol acetate which is notorious for causing secondary adrenal insufficiency. …”
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    FRI202 A Curious Case Of Psychosis
  13. 262953
    “…Abdominal imaging was unremarkable with a normal-appearing pancreas. Interestingly, the patient's daughter had similar gastric inflammatory symptoms and multiple members of the family have early-onset DM. …”
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    SAT079 A Novel Variant In The Carboxyl Ester Lipase (CEL) Gene Causing MODY
  14. 262954
    “…Results indeed showed few episodes of hypoglycemia with glucose levels in the 40s. Interestingly, she also had postprandial hyperglycemia with glucose level above 180 following an episode of hypoglycemia. …”
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    SAT172 Unmasking A Pediatric Disease In Adult, A Belated Diagnosis
  15. 262955
    “…We manipulated the levels of H19X in tamoxifen-resistant ER+ breast cancer cells to generate a comprehensive list of direct transcripts using 4sU-RNA-seq. Interestingly, H19X regulates the expression of estrogen-driven intergenic, divergent, and antisense transcripts whose promoters are bound by ER-alpha (ERα) binding sites. …”
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    OR22-06 Functional Characterization Of X-linked Genes In Regulating Epigenetic Landscape In Endocrine-resistant Breast Cancer
  16. 262956
    “…This hypothesis is being tested in vitro using primary HESCs. Interestingly, in the pregnant mouse, GPBAR1 mRNA is barely expressed at the implantation site on E7.5, and therefore unlikely plays a role in stromal cell decidualization in the mouse. …”
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    OR09-05 GPBAR1- Understanding Its Function In The Secretory Endometrium
  17. 262957
    “…Conclusion: This is an interesting case of primary hypoparathyroidism possibly of autoimmune origin. …”
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    SAT227 A 17-year old Teenager With Recurrent Syncopes In The Setting of Hypocalcemia
  18. 262958
    “…Survey data suggests that men are not only interested in male contraception but that a self-administered transdermal gel is desired by many men as an optimal form of contraceptive delivery. …”
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    FRI436 Design Of An International Male Contraceptive Efficacy Trial Using A Self-administered Daily Topical Gel Containing Testosterone And Nestorone™
  19. 262959
    “…Estradiol levels measured two days after cessation of vaginal bleeding normalized (7pg/mL) while LH/FSH remained prepubertal. Interestingly, two weeks after the bleeding stopped her pelvic ultrasound showed significantly enlarged ovaries (R 4.1mL, L 4.3mL), while her estradiol remained normal (5pg/mL). …”
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    THU197 Peripheral Precocious Puberty In A 6-year-old Girl With Extreme Estradiol Elevation With Rapid Normalization: A Case Report
  20. 262960
    por Alkwatli, Kenda, Khan, Leila Zeinab
    Publicado 2023
    “…Mild cases can present in adulthood and can be misdiagnosed. We present an interesting patient who was clinically diagnosed with hypophosphatasia despite negative molecular genetic testing. …”
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    THU459 Hypophosphatasia With Normal ALPL Gene Test; A Case Report
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