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  1. 263441
    “…After learning about the project through community agencies or social/sexual networking applications, gbMSM interested in PrEP will use a uniquely coded card to access an online information module that includes coaching on how to discuss their HIV risk with their FP. …”
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    Decentralizing the delivery of HIV pre-exposure prophylaxis (PrEP) through family physicians and sexual health clinic nurses: a dissemination and implementation study protocol
  2. 263442
    “…Fatigue is also frequently reported by IBS patients and the condition is considered as a common comorbidity of IBS. Therefore, it is interesting to see whether these two conditions share the same pathophysiological mechanism. …”
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    Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue
  3. 263443
    “…Radical and rapid action is required to achieve a better quality of life for older populations and to remain true to the principles of medical professionalism and evidence-based medicine that place patients’ interests and autonomy at the fore. This first International Group for Reducing Inappropriate Medication Use & Polypharmacy position statement briefly details the causes, consequences, and extent of inappropriate medication use and polypharmacy. …”
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    International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action
  4. 263444
    “…RESULTS: Using qRT-PCR, the T8-cultured SSc circulating fibrocytes which had not been treated with CTLA4-Ig showed higher gene expression for CD86, αSMA, S100A4, TGFβ, and COL I compared with HS circulating fibrocytes. Interestingly, αSMA/COL I gene expression was significantly lower only in the SSc circulating fibrocytes treated with CTLA4-Ig for 3 h (p < 0.01, p < 0.05). …”
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    Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay
  5. 263445
    “…This coincided with the evidence that cells expressing His6GFP could maintain their growth pattern in a similar fashion as that of the control cells even in the presence of harmful cadmium. Interestingly, overexpression of either OmpA or His-OmpA in E. coli cells has also been proven to confer protection against cadmium toxicity as comparable to that observed in cells expressing His6GFP. …”
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    Metal complexation by histidine-rich peptides confers protective roles against cadmium stress in Escherichia coli as revealed by proteomics analysis
  6. 263446
    “…PP16 induced low levels of specific IgG that increased 1 year after immunization. Interestingly, a low frequency of reactivity was found against SV11 in naturally infected dogs (symptomatic and asymptomatic), while 83.3% of vaccinated dogs presented positive responses 1 year after immunization. …”
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    Leishmania infantum Virulence Factor A2 Protein: Linear B-Cell Epitope Mapping and Identification of Three Main Linear B-Cell Epitopes in Vaccinated and Naturally Infected Dogs
  7. 263447
    “…At day 3 there was a major down-regulation of miRNA levels, which was partially recovered by day 14 post-injury. Interestingly, bone injury led to a significant up-regulation of let-7a, let-7d and miR-21 in plasma and splenocytes at day 14 relative to day 3 after bone injury, but not in sham operated animals. …”
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    Profiling the circulating miRnome reveals a temporal regulation of the bone injury response
  8. 263448
    “…Most previous T2D loci discovered in European studies did not associate with GDM in North India, indicative of different genetic etiology or alternately, differences in the linkage disequilibrium (LD) structure between populations in which the associated SNPs were identified and Northern Indian women. Interestingly some T2D risk variants were in fact indicative of being protective for GDM in these Indian women. …”
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    Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women
  9. 263449
    por Mathieson, Iain, Roodenberg, Songül Alpaslan, Posth, Cosimo, Szécsényi-Nagy, Anna, Rohland, Nadin, Mallick, Swapan, Olalde, Iñigo, Broomandkhoshbacht, Nasreen, Candilio, Francesca, Cheronet, Olivia, Fernandes, Daniel, Ferry, Matthew, Gamarra, Beatriz, Fortes, Gloria González, Haak, Wolfgang, Harney, Eadaoin, Jones, Eppie, Keating, Denise, Krause-Kyora, Ben, Kucukkalipci, Isil, Michel, Megan, Mittnik, Alissa, Nägele, Kathrin, Novak6, Mario, Oppenheimer, Jonas, Patterson, Nick, Pfrengle, Saskia, Sirak6, Kendra, Stewardson, Kristin, Vai, Stefania, Alexandrov, Stefan, Alt1, Kurt W., Andreescu, Radian, Antonović, Dragana, Ash, Abigail, Atanassova, Nadezhda, Bacvarov, Krum, Gusztáv, Mende Balázs, Bocherens, Hervé, Bolus, Michael, Boroneanţ, Adina, Boyadzhiev, Yavor, Budnik, Alicja, Burmaz, Josip, Chohadzhiev, Stefan, Conard, Nicholas J., Cottiaux, Richard, Čuka, Maja, Cupillard, Christophe, Drucker, Dorothée G., Elenski, Nedko, Francken, Michael, Galabova, Borislava, Ganetsovski, Georgi, Gély, Bernard, Hajdu, Tamás, Handzhyiska, Veneta, Harvati, Katerina, Higham, Thomas, Iliev, Stanislav, Janković, Ivor, Karavanić, Ivor, Kennett, Douglas J., Komšo, Darko, Kozak, Alexandra, Labuda, Damian, Lari, Martina, Lazar, Catalin, Leppek, Maleen, Leshtakov, Krassimir, Vetro, Domenico Lo, Los, Dženi, Lozanov, Ivaylo, Malina, Maria, Martini, Fabio, McSweeney, Kath, Meller, Harald, Menđušić, Marko, Mirea, Pavel, Moiseyev, Vyacheslav, Petrova, Vanya, Price, T. Douglas, Simalcsik, Angela, Sineo, Luca, Šlaus, Mario, Slavchev, Vladimir, Stanev, Petar, Starović, Andrej, Szeniczey, Tamás, Talamo, Sahra, Teschler-Nicola, Maria, Thevenet, Corinne, Valchev, Ivan, Valentin, Frédérique, Vasilyev, Sergey, Veljanovska, Fanica, Venelinova, Svetlana, Veselovskaya, Elizaveta, Viola, Bence, Virag, Cristian, Zaninović, Joško, Zäuner, Steve, Stockhammer, Philipp W., Catalano, Giulio, Krauß, Raiko, Caramelli, David, Zariņa, Gunita, Gaydarska, Bisserka, Lillie, Malcolm, Nikitin, Alexey G., Potekhina, Inna, Papathanasiou, Anastasia, Borić, Dušan, Bonsall, Clive, Krause, Johannes, Pinhasi, Ron, Reich, David
    Publicado 2018
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    The Genomic History of Southeastern Europe
  10. 263450
    “…Whole genome gene expression analysis confirmed inflammation as a key mechanism of bilirubin neurotoxicity in the auditory pathway and shared gene expression hallmarks induced by exposure to bacterial lipopolysaccharide (LPS) a well-characterized inducer of neuroinflammation. Interestingly, bilirubin caused more severe damage to the auditory system than LPS in this model, but consistent with our hypothesis of neuroinflammation being a primary part of bilirubin toxicity, the hearing loss was protected by perturbing the inflammatory response. …”
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    Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model
  11. 263451
    “…However, forkhead box M1 knockdown or overexpression had no effect on manganese superoxide dismutase levels but inhibited or promoted lung cancer stem-like cell functions. Interestingly, forkhead box M1 overexpression alleviated the inhibitory effects of manganese superoxide dismutase knockdown in lung cancer stem-like cells. …”
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    Upregulation of FoxM1 by MnSOD Overexpression Contributes to Cancer Stem-Like Cell Characteristics in the Lung Cancer H460 Cell Line
  12. 263452
    “…Similarly, in the case of tumor necrosis factor (TNF-α) concentration, where after two weeks of treatment with irradiation at a wavelength of 658 nm, a rapid suppression was observed (p=0.001), whereas in the other groups, these results were much slower and not as obvious. Interestingly, again in the case of group C, the change in TNF-α concentration in wound tissue was most intensive (≈75% reduction), whereas the changes in other groups were not as obvious (≈50% reduction). …”
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    Effect of laser therapy on expression of angio- and fibrogenic factors, and cytokine concentrations during the healing process of human pressure ulcers
  13. 263453
    “…Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4(+)/KI67(−) and ALDH1/2(+)/KI67(−)) and only KI67(+) cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region. Smaller spherical (≤ 5 μm) and larger spindle/elliptical shaped (~ 10 μm) cell populations with high nucleo-cytoplasmic ratio were detected across all samples (including normal ovaries) but with variable distribution and characteristic stage-wise marker expression across different tumor stages. …”
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    Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors
  14. 263454
    “…Major differences were found between post-ovulatory and the rest of the stages analyzed for mRNAs. Interesting miRNAs identified in oEVs and showing differential abundance among stages, miR-34c and miR-449a, have been associated with defective cilia in the oviduct and infertility. …”
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    Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo
  15. 263455
    “…Consistently, the overexpression of PAK1 reduces the dexamethasone‐induced expression of MuRF1 in myotubes and increases the phospho‐FOXO3/FOXO3 ratio. Interestingly, the ectopic expression of PAK1 counteracts atrophy in vitro by restraining the IL6‐Stat3 signalling pathway measured in luciferase‐based assays and by reducing rates of protein degradation in atrophying myotubes exposed to IL6. …”
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    Group I Paks support muscle regeneration and counteract cancer‐associated muscle atrophy
  16. 263456
    “…At the transcriptional level, senescence markers (p53, p21, p16, and β-galactosidase), proinflammatory markers (TNF-α, IL6, MCP1, and IL1-β), and epigenetic signature of histone deacetylase-3 (HDAC3) were significantly (p < 0.05) elevated in patients with type 2 diabetes compared to control subjects. Interestingly, mRNA expression of Sirt1 and telomere length were significantly (p < 0.05) decreased in patients with type 2 diabetes compared to control subjects. …”
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    Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes
  17. 263457
    “…BACKGROUND: Recently, we have developed a novel transgenic mouse model by overexpressing prohibitin (PHB) in adipocytes, which developed obesity due to upregulation of mitochondrial biogenesis in adipocytes, hence named “Mito-Ob.” Interestingly, only male Mito-Ob mice developed obesity-related impaired glucose homeostasis and insulin sensitivity, whereas female Mito-Ob mice did not. …”
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    Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis
  18. 263458
    “…Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain disorders, e.g., cognitive impairments. …”
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    The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
  19. 263459
    “…The slMFB emerges as an interesting region for the treatment of major depression (and other psychiatric diseases) with DBS. …”
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    Tractography-assisted deep brain stimulation of the superolateral branch of the medial forebrain bundle (slMFB DBS) in major depression
  20. 263460
    “…The ovaries samples were collected and processed for isobaric tags for relative and absolute quantification analysis (iTRAQ) to screen out our interested proteins of HSPA5 and HSP90AB1, and the decline in their expression were verified by a real-time quantitative PCR and a western blotting assay. …”
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    Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage
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