“…Yet, there are no standardized protocols of the frequency of thyroid function monitoring in patients treated with these drugs. Interestingly, the onset of thyroid dysfunction occurred on an average within first 7 weeks and 3-4 doses of treatment initiation. …”
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“…Of these adverse events 5 (5.7%) were secondary to estrogen, 2 (2.3%) were secondary to testosterone, and 1 (1.1%) was secondary to spironolactone. Interestingly, only 5 (5.7%) were symptomatic (venous thromboembolism, myocardial infarction, hyperkalemia) while 3 (3.4%) were asymptomatic (elevated hematocrit, elevated prolactin). …”
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“…Clinicians reported considering the following factors for LT4 treatment decision: TSH level, TPO-Abs, history of miscarriages, and guidelines recommendations. Interestingly, 70-80% of the clinicians who would start LT4, consider treatment would have a small impact (10-20% reduction) or very small impact (<10% reduction) on maternofetal complications regardless the clinical scenario. …”
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“…Introduction: Pheochromocytomas (PCCs) are rare catecholamine-producing neuroendocrine tumors, mostly arising from the adrenal medulla (85%). We present an interesting case of a young woman with developmental delay who was diagnosed with pheochromocytoma after presenting with abdominal distention as the only initial complaint. …”
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“…Urology recommended gonadectomy followed by hormone replacement therapy but patient was not interested. Despite a multidisciplinary approach, GI or GD was never addressed throughout the 10-year follow up. …”
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“…High throughput sequencing (HTS) could be an interesting tool to identify these rare variants. OBJECTIVE: To identify rare genetic variants through HTS in a selection of patients with PCOS clinical relevant phenotypes or familial PCOS clusters. …”
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“…We describe the clinical course and associated findings in this family and discuss the evaluation and management of this interesting condition.…”
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“…A significant increase in both Muscle- and Skin-SC at follow-up compared to first diagnosis was detected (19.4 vs. 14, p<0.05 and 19.3 vs. 12.1, p<0.05), consistent with a significant decrease in PRC (200 vs. 31.2 ng/l, p<0.05). Interestingly, patients with chronic PAI under replacement therapy exhibited significantly higher Muscle-SC compared to controls. …”
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“…Low levels of 11-oxyandrogens were detected in dogs, cows, sheep and horses. Interestingly, pigs and guinea pigs had significant circulating levels of 11-oxyandrogens. …”
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“…Knocked-down expression of CPAP decreased the HBx-mediated tumorigenic effects, including cytokines secretion. Interestingly, overexpressed CPAP maintained the HBx protein stability in an NF-κB-dependent manner; and the expression levels of CPAP and HBx were positively correlated with the activation status of NF-κB in HCC. …”
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“…Conclusions: ACROVAL® detected disease activity in 51.8% of patients. Interestingly, although S-DA patients were likely to be in the process of being controlled, action was not always taken in these patients. …”
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“…HSQC peak intensities of PTH residues 21-34 are significantly reduced in the presence of ECD, suggesting that the flexibility of helical PTH(21-34) is compromised upon binding to ECD. Interestingly, peaks of L15 and S17, which participate in the hinge, disappear in the presence of ECD. …”
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“…Spectral karyotyping revealed a variable number of chromosomes amongst cells, a result confirmed by shallow single-cell DNA sequencing in LβT2 cells. Interestingly, STR genotyping of several LβT2 batches obtained regularly throughout the past 20 years in our laboratory as well as in other laboratories identified a strain (#2) with a profile distinct from our reference line (#1). …”
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“…Mean LH concentrations were significantly increased after kisspeptin injection in animals treated with saline (saline, pre: 3.8 ± 0.6 vs. post: 7.8 ± 0.5 ng/ml). Interestingly, the LH response to kisspeptin in animals treated with insulin was also markedly increased (insulin, pre: 3.2 ± 0.6 vs. post: 6.4 ± 0.3 ng/ml), but not significantly different from animals treated with saline. …”
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“…CONCLUSION: Early diagnosis of CAIS is important as this helps guide pharmacotherapies, surgery, malignancy surveillance, genetic counseling, and psychosocial support; all of which help determine a patient’s sexual identity. This case is interesting because the patient was diagnosed far past menarche in her fourth decade, which proved to be psychologically distressing given the patient was unaware of the presence of testes. …”
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“…TRα plays an important role in the maintenance of muscle mass and skeletal muscle regeneration after injury with aging, and loss of skeletal muscle mass with aging in TRα1PV mice was reported to be associated with loss of SC pool {1,2}. Interestingly, overexpression of the nuclear orphan receptor Chicken Ovalbumin Upstream Promoter-factor II (COUP-TFII or NR2F2) in murine satellite cells have been shown to induce a similar skeletal muscle phenotype, including skeletal muscle loss with aging, and inhibit myogenesis through modulation of Myf5 and MyoD expression {3}. …”
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“…Rarely, diabetic neuropathy affects the intercostal neural roots causing severe and difficult to treat thoracic and abdominal pain. We present an interesting case where diagnosis of thoracic radiculopathy was made 8 years later. …”
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“…Adipocytes collected from female rats cultured in fulvestrant and T (Fulv + T) had increased transcript levels of Insr, Irs1, Akt2 in VWAT and SCWAT. Interestingly, Fulv + T increased protein phosphorylation of AKT and FOXO1 only in VWAT adipocytes from females. …”
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“…Background: Vasomotor symptoms such as hot flashes and sweating, typical of the menopausal syndrome in women, are less commonly seen in males after loss of testicular function. We present an interesting case of a middle-aged man who was evaluated for progressive episodes of hot flashes, sweating and flushing and was eventually diagnosed with pituitary macroadenoma causing secondary hypogonadism. …”
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“…Inhibition of the NFkB inflammatory pathway (PS1145) or iNOS (L-NAME or TRIM) did not abrogate the BPA-mediated Npy induction, demonstrating that inflammation and iNOS do not appear to upregulate Npy. Interestingly, treatment of the mHypoA-59 cells with BPA in an antioxidant-rich media, neurobasal A (NBA), mitigated the BPA-induced increase in Npy. …”
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