“…This case demonstrates a challenging diagnostic dilemma and reveals subtle nuances in the workup and management of a post-partum patient with hypoglycemia. It also raises interesting questions regarding the effects of pregnancy hormones on the growth and presentation of insulinomas.…”
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“…This effect of DHT on HIF1α protein level was blocked by flutamide (AR inhibitor), LY294002 (PI3K inhibitor) as well as cyclohexamide (protein translational inhibitor). Interestingly the 5’ prime end of JMJD3 have HIF1α response elements (HRE) and it is well established that several JMJDs are induced by HIF1α under both normal conditions and hypoxic stress. …”
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“…Breast and lung cancer are the most common primary cancer of PM. We report an interesting case of metastatic breast cancer with pituitary gland involvement debuting with diabetes insipidus as the initial symptom. …”
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“…We found no association between AAC and serum creatinine, serum calcium, serum 25(OH)D, beta-crosslaps, and bone specific alkaline phosphatase. Interestingly, we found that as PTH increased over time, the odds of calcification (AAC >=5) also increased (p-value for time and PTH interaction was 0.009). …”
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“…When we examined female MSI-null somatotrope animals, a much smaller cohort of genes showed a change in expression (153 genes, FDR <0.05). Interestingly, 38 genes were altered in both mutant males and females suggesting shared regulation by MSI. …”
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“…Female mice that received bilateral intracerebroventricular injections at postnatal day (PND) 1 with recombinant virus expressing Mkrn3 had delayed vaginal opening and first estrus, compared to control-virus injected animals, with subsequent normal cyclicity and fertility. Interestingly, male mice did not exhibit delayed puberty onset, determined by preputial separation, following Mkrn3 overexpression through the same paradigm. …”
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“…Adipocytes exposed to monocytes or to monocyte media elevated miR106b by 7 to 12-fold (n=8, p<0.01). Interestingly, cord blood plasma miR106b levels were found to inversely correlate with 25(OH)D levels (n=27, Spearman r=-0.41, p<0.04). …”
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“…Patients with positive Nek2B expression were less sensitive to paclitaxel-containing neoadjuvant chemotherapy. Interestingly, in a panel of established TNBC cell line, Nek2B and β-catenin were highly expressed in cells exhibiting paclitaxel resistance. …”
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“…It was shown in our cell model that JAG2 was involved in the regulation of migration and invasion independent of the canonical Notch signaling pathway. More interestingly, JAG2 also promoted the migration and invasion of colon cancer cells in a non-EMT pathway. …”
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“…Sevelamer carbonate could represent an interesting option to limit the elevation of gut-derived uremic toxins. …”
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“…However, details of study delivery and additional outcome criteria vary to accommodate local contexts, interests and priorities. The studies will be analysed separately, but with the option to compare and combine findings. …”
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“…More clinicians who reported feeling “great/good” said they always/sometimes had enough time to spend with patients (66.1%) compared to those that hardly ever/never had enough time (26.3%), χ(2)(1, N = 75) = 6.62, P = .0101; CMH row mean scores differ statistic). Interestingly, 40.3% of patients preferred a paternalistic style of decision-making compared to 6.3% of clinicians, χ(2)(2, N = 146) = 27.46, P < .0001; χ(2) test. …”
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“…This model might identify Nanos3 as an interesting target in cancer therapeutics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-019-5807-x) contains supplementary material, which is available to authorized users.…”
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“…We studied the regulation of C/EBP homologous protein (CHOP), a proapoptotic ER-stress-related transcription factor (TF) in AECII-like cells. Interestingly, single or combined overexpression of the active ER stress transducers activating transcription factor-4 (Atf4) and activating transcription factor-6 (p50Atf6) or spliced x-box-binding protein-1 (sXbp1) in MLE12 cells did not result in a substantial Chop induction, as compared to the ER stress inducer thapsigargin. …”
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“…We integrated gene expression analyses with genome-wide ARID1A occupancy and epigenomic mapping data to decipher ARID1A-dependent transcriptional regulatory mechanisms. RESULTS: Interestingly, we found that CRC cell lines harboring KRAS mutations are critically dependent on ARID1A function. …”
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“…Heterogeneous expression of 30 candidate cDNAs from the GH5 family in E. coli BL21 showed that 17 of the tested proteins had endoglucanase activity, while 7 exhibited exoglucanase activity. Interestingly, two of the GH5 proteins (Cel5A-h28 and Cel5A-h11) showed high specific activity against carboxymethylcellulose (CMC) and p-nitrophenyl-β-d-cellobioside (pNPC) (222.2 and 142.8 U/mg), respectively. …”
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“…These properties of BglucLEH make it an interesting tool to reduce cost, to improve the efficiency of biocatalyst and potentially to enhance the degradation of lignocellulosic biomass. …”
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“…Regression analysis revealed that age (P=.04) and missing information owing to the use of SDs (P=.02) were major predictors of committing an error in the ED. Interestingly, more than 40% of the respondents were significantly addicted to using SDs and more than one-third felt the need to cut down their use. …”
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“…Determination of CER could be an interesting addition to the imaging technique armamentarium available and applied for evaluation of muscle mass in clinical intervention studies and observational studies.…”
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“…Here, we investigated the role of CX(3)CR1 in the neuroinflammation induced by infection with Japanese encephalitis virus (JEV), a neurotrophic virus. Interestingly, CX(3)CR1 deficiency strongly enhanced susceptibility to JEV only after peripheral inoculation via footpad. …”
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