“…TRPM7 expression in GBM cells was found to be positively correlated with Notch1 signaling activity and CD133 and ALDH1 expression; briefly, downregulation of TRPM7 by siTRPM7 decreased Notch1 signaling whereas upregulation of TRPM7 increased Notch1 signaling. Interestingly, kinase-inactive mutants (M7-DK and M7-KR) resulted in reduced activation of Notch1 signaling and decreased expression of CD133 and ALDH1 compared to that of wtTRPM7. …”
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“…SETTING: Five UK centres interested in COPD. PARTICIPANTS: Population-based sample including 714 individuals with spirometry-defined COPD, smoked at least 10 pack years and who were clinically stable for >4 weeks. …”
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“…Hazardous alcohol use and PEth results did not predict one-month retention in this small sample CONCLUSION: Young men engaging in risky behavior were interested and willing to engage in PrEP through a community-based PrEP model. …”
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“…Table 1 [Image: see text] Figure 1 [Image: see text] Figure 2 [Image: see text] CONCLUSION: Serious infections common in PWID are increasing in TN and the US; they correlate with HCV rates, which have risen significantly in hospitalized patients. Interestingly, opioid use disorder incidence from discharge data declined from 2001-2014 for both TN and the US, which may be due to coding lapses or shifts in type of opioid use with no well-known billing code. …”
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“…Though several inflammatory markers (d-dimer, CRP, procalcitonin) initially predicted mortality, they failed in multivariate analysis, questioning their role in risk-stratifying COVID-19 hospitalized patients. Interestingly, IL-6 used in those severely ill patients to assess candidacy for IL-6 inhibitor therapy (Tocilizumab) failed to predict mortality in our study. …”
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“…A disproportionate number of patients were African American/Black or Hispanic at 72.2% (n=52). Interestingly, Caucasian race was significantly associated with less severe outcomes (p=0.038). …”
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“…For further support, our institution created a dedicated Addiction medicine consult service March 1, 2019 to assist with initiation of medications for opioid use disorder (MOUD) and linkage to outpatient care for interested patients. METHODS: We performed retrospective review of all patients > 18 years with OUD admitted for procedure/inpatient stay from 1/31/2018 – 1/31/2020 who discharged to medical respite for OPAT. …”
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“…At the mucosal level evaluating the balance within pro anti-inflammatory cytokines and micro-biome will be interesting to study. FSD is detected in more than half of HIV infected women and seems to be related to testosterone levels. …”
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“…CONCLUSION: Admission from a healthcare facility, Pitt bacteremia score ≥ 4, and pulmonary source of bacteremia were associated with increased risk of 30-day mortality. Interestingly, administration of active empiric therapy was not associated with a decreased mortality risk. …”
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“…Table 1: Molecular and Metagenomic Testing of Persons Under Investigation [Image: see text] CONCLUSION: Unbiased mNGS offers the powerful opportunity to streamline testing for PUIs by assessing for SARS-CoV-2 and alternative infections simultaneously; this technique can also be used to identify co-infections, but none were observed in our study population. Interestingly, many PUIs had no infection identified on routine testing or mNGS, which may reflect inadequate sampling, rapid virus clearance, or a non-viral process. …”
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“…Social service workers reported positive experiences with using new technologies in health promotion, and interests in future collaborations involving more ICT. …”
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“…Key motivators for implementation included the GPs’ professional values and interests, but pragmatic considerations were also of importance (coherence). …”
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“…We observed a significant reduction in serum triglycerides [p = 0.045, effect size (ɳ(p)(2)) = 0.15; SBF: −0.26 ± 0.77 mmol/L, LIPA: −0.26 ± 0.51 mmol/L], improved 30 s sit-to-stand (STS) count (p = 0.002, ɳ(p)(2) = 0.32, 2 ± 3 STS) and speed (p = 0.009, ɳ(p)(2) = 0.35, −10 ± 33%), as well as increased average handgrip strength (p = 0.001, ɳ(p)(2) = 0.45, 6 ± 12%), and gait speed (p = 0.005, ɳ(p)(2) = 0.27, 0.09 ± 0.16 m/s) in both groups. Interestingly, SBF caused a greater increase in peak handgrip strength (8 ± 14%), compared to LIPA (2 ± 10%; p = 0.04, ɳ(p)(2) = 0.38). …”
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“…Compared with non-severe patients, severe patients were more likely to have the symptoms of dyspnea, hemoptysis, and the complications of ARDS, shock, secondary infection, acute kidney injury, and acute cardiac injury. Interestingly, the former smokers were more prevalent in severe cases as compared to non-severe cases, but there was no difference between the two groups of ‘current smokers’. …”
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“…Furthermore, the NNMT-related nomogram showed that NNMT shared a larger contribution to OS, compared with debulking status. More interestingly, bevacizumab conferred significant improvements in OS for patients with low NNMT expression (HR: 0.56, 95%CI: 0.31–0.99, Log-rank P = 0.049). …”
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“…It exists in two isomeric forms i.e. 1,2,4-triazole and 1,2,3-triazole and is used as core molecule for the design and synthesis of many medicinal compounds. 1,2,4-Triazole possess broad spectrum of therapeutically interesting drug candidates such as analgesic, antiseptic, antimicrobial, antioxidant, anti-urease, anti-inflammatory, diuretics, anticancer, anticonvulsant, antidiabetic and antimigraine agents. …”
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“…RESULTS: We developed a novel DNMT3a knock-out model to show that sequential knock-out of DNA methyltransferase 3a isoforms (DNMT3aa(−/−) and DNMT3aa(−/−)ab(−/−)) additively decreased survival and increased deformities when cold developmental temperatures in zebrafish offspring mismatched warm temperatures experienced by parents. Interestingly, short-term cold acclimation of parents before breeding rescued DNMT3a knock-out offspring by restoring survival at cold temperatures. …”
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“…CONCLUSIONS: Most MSM were interested in using various potential future HIV prevention products, especially LAI. …”
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“…ERIC-PCR yielded 14 profiles and five main clusters. Interestingly, human and chicken C. jejuni isolates were clustered together in ERIC-PCR clusters II-V, which confirmed the genetic relatedness between the isolates from both origins. …”
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“…Tramadol could protect COVID-19 patient from disease complications by increases the antioxidant enzymes superoxide dismutase and glutathione peroxidase while diminished malondialdehyde. More interestingly, tramadol as an effective analgesic and antitussive may have a beneficial effect on COVID-19 patients suffering from cough, headache, ache, and pain. …”
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