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264381por Watson, Joshua, Wang, Tianfang, Ho, Kun-Lin, Feng, Yuan, Mahawan, Tanakamol, Dobbin, Kevin K., Zhao, Shaying“…Further analysis reveals that these ER−PR+ canine tumors harbor additional basal-like features, including upregulation of genes of interferon-γ response and of the Wnt-pluripotency pathway. Interestingly, we observed an association of PGR expression with gene silencing in all canine tumors and with the expression of T cell exhaustion markers (e.g., PDCD1) in ER−PR+ canine tumors. …”
Publicado 2023
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264382por Wang, Xianwei, Liu, Lu, Jiang, Xiaohua, Saredy, Jason, Xi, Hang, Cueto, Ramon, Sigler, Danni, Khan, Mohsin, Wu, Sheng, Ji, Yong, Snyder, Nathaniel W., Hu, Wenhui, Yang, Xiaofeng, Wang, Hong“…Through further combinatory analysis with transcriptome from MG Aβ phagocytosis model, we identified 130 functional-validated Aβ phagocytic AD MG DEGs (20 in human AD, 110 in mouse AD), which reflected a compensatory activation of Aβ phagocytosis. Interestingly, we identified 14 human Aβ phagocytic AD MG DEGs which represented impaired MG Aβ phagocytosis in human AD. …”
Publicado 2023
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264383por Khan, A., Inkster, A. M., Peñaherrera, M. S., King, S., Kildea, S., Oberlander, T. F., Olson, D. M., Vaillancourt, C., Brain, U., Beraldo, E. O., Beristain, A. G., Clifton, V. L., Del Gobbo, G. F., Lam, W. L., Metz, G. A. S., Ng, J. W. Y., Price, E. M., Schuetz, J. M., Yuan, V., Portales-Casamar, É., Robinson, W. P.“…Cell composition estimates varied both within and between cohorts, as well as over very long placental processing times. Interestingly, the ratio of cytotrophoblast to syncytiotrophoblast proportion decreased with increasing gestational age, and differed slightly by both maternal ethnicity (lower in white vs. non-white) and genetic ancestry (lower in higher probability European ancestry). …”
Publicado 2023
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264384por He, Xue, Shao, Guoqing, Du, Xiaodi, Hua, Ruiqi, Song, Hongyu, Chen, Yanxin, Zhu, Xiaowei, Yang, Guangyou“…RESULTS: In this study, we identified four EgANXBs with conserved protein structures and calcium-dependent phospholipid binding activities. rEgANXBs were recognized by serum from sheep infected with E. granulosus and distributed in the germinal layer of fertile cysts. Interestingly, transcription levels of the four EgANXBs were significantly higher in protoscoleces than in 28-day strobilated worms. …”
Publicado 2023
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264385por Wu, Lei, Li, Hui, Chen, Huanzhen, Fan, Chunyu, Lu, Yan, Wei, Ruipeng, Yang, Guangzhao, Jia, Yongping“…Longitudinally, CDC42 decreased from baseline to D1 and then gradually increased to D7 (P < 0.001) in SV-CAD patients after DCB. Interestingly, high CDC42 (cut-off value = 500 pg/mL) at baseline (P = 0.047), D3 (P = 0.046), and D7 (P = 0.008) was associated with a lower accumulating target lesion failure (TLF) rate; high CDC42 at D3 (P = 0.037) and D7 (P = 0.041) was related to a lower accumulating major adverse cardiovascular event (MACE) rate in SV-CAD patients underwent DCB. …”
Publicado 2023
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264386por Fan, Yongliang, Jin, Long, He, Zhiping, Wei, Tiantian, Luo, Tingting, Zhang, Jiaman, Liu, Can, Dai, Changjiu, A, Chao, Liang, Yan, Tao, Xuan, Lv, Xuebin, Gu, Yiren, Li, Mingzhou“…After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. …”
Publicado 2023
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264387por Sharaf, Mahmoud S., Othman, Ahmad A., Abd El Ghaffar, Amira E., Ali, Dareen M., Eid, Mohamed M.“…However, the ivermectin-treated group showed incomplete histopathological and biochemical resolution. Interestingly, both clinical cure and negative skin scrapings were noticed earlier in the fluralaner-treated group, with no apparent side effects. …”
Publicado 2023
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264388por De Meulenaere, Katlijn, Cuypers, Bart, Gamboa, Dionicia, Laukens, Kris, Rosanas-Urgell, Anna“…To minimize the number of core genome variants in non-South American samples, PvW1 is most suited for Southeast Asian isolates, both PvPAM and PvW1 are suited for South Asian isolates, and PvPAM is recommended for African isolates. Interestingly, non-South American samples still contained the least subtelomeric variants when mapped to PvPAM, indicating high quality of the PvPAM subtelomeric regions. …”
Publicado 2023
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264389por Sanna, Cinzia, Chiocchio, Ilaria, Mandrone, Manuela, Bonvicini, Francesca, Gentilomi, Giovanna A., Trincia, Simona, Poli, Ferruccio“…Samples collected in this season were also the most active ones as antibacterial. Moreover, an interesting metabolomic profile enriched in catechins and flavonols was observed in leaves collected in winter on flowering branches which were endowed with high antioxidant potential. …”
Publicado 2023
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264390por Amano, Masayuki, Otsu, Sachiko, Uemura, Yukari, Ichikawa, Yasuko, Matsumoto, Shota, Higashi-Kuwata, Nobuyo, Matsushita, Shuzo, Shimada, Shinya, Mitsuya, Hiroaki“…However, neutralization-activity of sera post-5th-(bv)BNT-dose was low against BQ.1.1/XBB/XBB.1.5. Interestingly, participants receiving (bv)BNT following breakthrough (BT) infection during Omicron-wave had significantly enhanced neutralization-activity against SCoV2(Wuhan)/BA.2/BA.5 with ~ 4.6-/~ 6.3-/~ 8.1-fold greater gMean-NT(50), respectively, compared to uninfected participants receiving (bv)BNT. …”
Publicado 2023
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264391por Eren, Neriman, Gerike, Susanna, Üsekes, Berk, Peters, Oliver, Cosma, Nicoleta-Carmen, Hellmann-Regen, Julian“…While AS did not differentially modulate TREM2 compared to standard fetal calf serum (FCS), AS decreased APOE levels in M2 macrophages but increased levels in M1 macrophages. Interestingly, higher levels of TREM2 and lower levels of APOE were detected in female- than in male- LOAD patients. …”
Publicado 2023
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264392“…Pathway analysis showed significantly affected glycine and serine metabolism, glycolysis, branched-chain amino acid (BCAA) metabolism, and other amino acid metabolisms. Interestingly, no tricarboxylic acid cycle metabolites were affected. …”
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264393“…RESULTS: IgG-IC-induced ALI is attenuated by the PDE4-selective inhibitor, which is due to reduced expressions of cytokine and chemokines. Interestingly, we find that cAMP downstream effector molecule PKA but not Epac is involved in negative regulation of IgG-IC-mediated pro-inflammatory mediators’ productions. …”
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264394por Gao, Yahui, Marceau, Alexis, Iqbal, Victoria, Torres-Vázquez, Jose Antonio, Neupane, Mahesh, Jiang, Jicai, Liu, George E., Ma, Li“…By linking GWAS results and transcriptome data from the CattleGTEx project via TWAS, we detected four and 23 significant gene-trait association pairs for heifer livability and early calving, respectively. Interestingly, we discovered six genes for early calving in the Bovine MHC region, including two genes in lymph node tissue and one gene each in blood, adipose, hypothalamus, and leukocyte. …”
Publicado 2023
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264395por Klupp, Eva-Maria, Knobling, Birte, Franke, Gefion, Belmar Campos, Cristina, Maurer, Philipp M., Knobloch, Johannes K.“…Against Gram-positive microorganisms such as E. faecium, E. faecium (VRE) and methicillin resistant S. aureus the gloves showed only very low antimicrobial activity with a reduction factor < 1 log(10) even after 10 min in bright conditions. Interestingly, comparable results for experiments with A. baumannii and E. faecium were shown under dark conditions. …”
Publicado 2023
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264396por Chen, Yang, Guo, Yanchen, Chang, Hao, Song, Zebu, Wei, Zhi, Huang, Zhao, Zheng, Zezhong, Zhang, Guihong, Sun, Yankuo“…Furthermore, we also found that ferroptosis agonist cisplatin treatment inhibited ASFV replication in a dose-dependent manner and the inhibitory effect of brequinar on ASFV was partially reversed by the ferroptosis inhibitor ferrostatin-1, suggesting that brequinar activates ferroptosis to inhibit ASFV replication. Interestingly, exogenous uridine supplementation attenuated the anti-ASFV activity of brequinar, indicating that brequinar inhibits ASFV replication by inhibiting DHODH activity and the depletion of intracellular pyrimidine pools; however, the induction of ferroptosis by brequinar treatment was not reversed by exogenous uridine supplementation, suggesting that brequinar activation of ferroptosis is not related to the metabolic function of pyrimidines. …”
Publicado 2023
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264397por Moazzeni, Seyyed Saeed, Karimi Toudeshki, Kimia, Ghorbanpouryami, Fatemeh, Hasheminia, Mitra, Azizi, Fereidoun, Pishgahi, Mehdi, Hadaegh, Farzad“…RESULTS: During a median follow-up of 12.2 years, 313 men and 375 women developed T2DM. Interestingly, a significant sex-difference was found (all P-values for sex interaction < 0.025). …”
Publicado 2023
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264398por Zadjelovic, Vinko, Wright, Robyn J., Borsetto, Chiara, Quartey, Jeannelle, Cairns, Tyler N., Langille, Morgan G. I., Wellington, Elizabeth M. H., Christie-Oleza, Joseph A.“…Our genome-centric analysis allowed the assembly of 215 Metagenome Assembled Genomes (MAGs), linking ARGs and other virulence-related genes to their host. Interestingly, a MAG belonging to Escherichia –that clearly predominated in water– harboured more ARGs and virulence factors than any other MAG, emphasising the potential virulent nature of these pathogenic-related groups. …”
Publicado 2023
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264399por Sun, Jing, Chen, Juanjuan, Xie, Qinfang, Sun, Mengjiao, Zhang, Wenjing, Wang, Hongxia, Liu, Ning, Wang, Qi, Wang, Manxia“…The numbers of Th1, Th17, Tfh, and B cells were significantly increased while that of Treg cells was obviously decreased in EAMG mice compared with controls. Interestingly, NaB treatment has reduced the amounts of Th17, Tfh, and B cells but increased that of Treg cells. …”
Publicado 2023
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264400por Wu, Anthony Yan-Tang, Sekar, Ponarulselvam, Huang, Duen-Yi, Hsu, Shu-Hao, Chan, Chi-Ming, Lin, Wan-Wan“…Although PARP-1 inhibitor olaparib increases DNA damage, ROS production, and cell death, it also blocks AMPK activation caused by UVA. Interestingly we found a dramatic nuclear export of AMPK upon UVA irradiation which is blocked by N-acetylcysteine and olaparib. …”
Publicado 2023
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