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  1. 264741
    por Nam, Hyung-song, Capecchi, Mario R.
    Publicado 2023
    “…RESULTS: We observed the Lrig1-lineage labeled cells with morphologies consistent with neurogenic stem cell identity in postnatal, juvenile, and adult mouse brains. Interestingly, when induced at postnatal or juvenile ages, morphologically distinct cells were revealed, including cells with the canonical B1 type stem cell morphology. …”
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    Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation
  2. 264742
    “…VN1, VN4, O1 lines were selected considering the agronomic evaluations and the RPGR% results as the most interesting for commercial exploitation. A physiological characterization was conducted by evaluating salt tolerance under hydroponic conditions. …”
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    Marker-Assisted Introgression of the Salinity Tolerance Locus Saltol in Temperate Japonica Rice
  3. 264743
    por Link, Tobias, Ehrmann, Matthias A.
    Publicado 2023
    “…Both strains, have a great overlap in their response to the culture conditions but some strain specific features such as the utilization of glycerol, sorbitol and arginine contribute to the overall fitness of the strain TMW 2.2256. Interestingly, although both strains have two non-identical copies of the tagatose-6P pathway and the Leloir pathway increased under the same conditions, TMW 2.2256 prefers the degradation via the tagatose-6P pathway while TMW 2.2254 does not. …”
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    Transcriptomic profiling reveals differences in the adaptation of two Tetragenococcus halophilus strains to a lupine moromi model medium
  4. 264744
    “…METHODS: We searched PubMed, Embase and clinicaltrials.gov to identify randomised controlled trials (RCTs), controlled before-after (CBAs) studies, and interrupted time series (ITS) studies assessing population-level infrastructure or policy and regulatory interventions to increase physical activity. We were interested in the effects of these interventions on physical activity, body weight and related measures, blood pressure, and CVD and type 2 diabetes morbidity and mortality, and on other secondary outcomes. …”
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    Infrastructure, policy and regulatory interventions to increase physical activity to prevent cardiovascular diseases and diabetes: a systematic review
  5. 264745
    “…The lack of proper control and quality monitoring may also negatively affect the interests of patients and their rights to receive adequate information about their health status.…”
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    Exploring the factors impacting physicians’ attitudes toward health information exchange with patients in Jordanian hospitals
  6. 264746
    “…BACKGROUND: Astrephomene is an interesting green algal genus that, together with Volvox, shows convergent evolution of spheroidal multicellular bodies with somatic cells of the colonial or multicellular volvocine lineage. …”
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    Cryopreservation of two species of the multicellular volvocine green algal genus Astrephomene
  7. 264747
    “…In addition, most adults planning to quit were interested in trying complementary approaches to facilitating tobacco cessation, which is currently lacking. …”
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    Reducing tobacco-associated lung cancer risk: a study protocol for a randomized clinical trial of AB-free kava
  8. 264748
    “…Moreover, LPPC/MP/CD28 complexes could eliminate metastatic B16F10 melanoma cells in the lung more efficiently than LPPC/MP. Interestingly, the melanoma resistance of mice treated with LPPC/MP/CD28 complexes would be reversed to susceptible after administration with LPPC/MP/CTLA4 complexes. …”
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    A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy
  9. 264749
    “…Cluster analysis revealed two clusters with low and relatively high activity in both dimensions (cluster 2 and 3). Interestingly, a third cluster (cluster 1) was characterized by high activity and low extent of ambulation. …”
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    The relationship between self-reported physical frailty and sensor-based physical activity measures in older adults – a multicentric cross-sectional study
  10. 264750
    “…Comparisons with ATAC-seq and RNA-seq data demonstrate that reduced methylation is associated with increased expression of fiber cell abundant genes, including crystallins, intermediate filament (Bfsp1 and Bfsp2) and gap junction proteins (Gja3 and Gja8), marked by high levels of histone H3.3 within their transcribed regions. Interestingly, Pax6-binding sites exhibited predominantly DNA hypomethylation in lens chromatin. …”
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    Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
  11. 264751
    “…Of patients with positive genetic findings (N = 325), 67.7% were less than 5 years of age, and 60% were offered modified management and/or intervention plans. Interestingly, 24% of patients with positive genetic findings received delayed diagnoses (average age, 12.4 years; range 7–37 years), most likely due to a lack of access to genomic investigations in this region. …”
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    The genomic landscape of rare disorders in the Middle East
  12. 264752
    “…Logistic regression analysis showed H-HbA1c was the independent risk factor for the development of OF in AP. Interestingly, in patients with presence history of diabetes and HbA1c <6.5%, the severity of AP was significantly lower than that in H-HbA1c group. …”
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    Elevated serum HbA1c level, rather than previous history of diabetes, predicts the disease severity and clinical outcomes of acute pancreatitis
  13. 264753
    “…Two small-molecule compounds and one antibody could be used as therapeutic drugs for GBM. Interestingly, the Wnt signaling pathway appeared in both KEGG and GO functional terms. …”
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    FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report
  14. 264754
    “…CONCLUSIONS: Specifying the components of SAIA provides improved conceptual clarity to enhance reproducibility for other researchers and practitioners interested in applying the SAIA across novel settings. …”
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    The Systems Analysis and Improvement Approach: specifying core components of an implementation strategy to optimize care cascades in public health
  15. 264755
    “…SDS-PAGE-based analysis of barley lines separated 12 hordein bands between C (four bands) and B (eight bands) subunits. Interestingly bands 52, 46a, and 46b were uniquely conserved in the four naked barley lines (Acc#16809–14,16956–11, 17240–3, 17244–19). …”
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    The association between hordein polypeptide banding and agronomic traits in partitioning genetic diversity in six-rowed Ethiopian barley lines (Hordeum vulgare L.)
  16. 264756
    “…CONCLUSIONS: UL clinical measures were the most important predictors of the subsequent UL performance category in this exploratory analysis regardless of the machine learning algorithm used. Interestingly, cognitive and affective measures emerged as important predictors when the number of input variables was expanded. …”
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    Predicting later categories of upper limb activity from earlier clinical assessments following stroke: an exploratory analysis
  17. 264757
    “…BACKGROUND: Virus-like particles are an interesting vector platform for vaccine development. …”
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    Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice
  18. 264758
    “…Participants believed HIV testing would be a barrier for men interested in accessing PrEP. Men recommended that access to PrEP be convenient, rapid, and community-based (i.e., not clinic-based). …”
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    What motivated men to start PrEP? A cross-section of men starting PrEP in Buffalo city municipality, South Africa
  19. 264759
    “…However, a putative disadvantage of implementing the contrast of high- versus low-calorie stimuli might be the omission of some interesting outcomes due to lower statistical power. …”
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    Evaluation of visual food stimuli paradigms on healthy adolescents for future use in fMRI studies in anorexia nervosa
  20. 264760
    “…There were 649 transcripts commonly expressed between the potato cultivars and time points, of which 627 and 22 were up- and down-regulated, respectively. Interestingly, overall the up-regulated DEGs were twice in number as compared to down-regulated ones in all the potato cultivars and time points, except Kuras at 36 h post-inoculation. …”
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    Comprehensive transcriptome analysis of different potato cultivars provides insight into early blight disease caused by Alternaria solani
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