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264861“…These stimuli included the gram-positive pathogen Staphylococcus aureus (S. aureus) and its cell wall product peptidoglycan (PGN), a Toll-like receptor 2 (TLR2) agonist; the TLR3 ligand polyinosine-polycytidylic acid (polyI:C), a synthetic mimic of viral double-stranded RNA; lipopolysaccharide (LPS) a TLR4 agonist; and the TLR9 ligand CpG oligonucleotide (CpG-ODN), a synthetic form of bacteria/viral DNA. RESULTS: Interestingly, the relative numbers of microglia recovered from mixed glial cultures following the initial harvest were not influenced by GM-CSF. …”
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264862por Joslin, Elliott P.“…The amount of urine was increased by more than 50 per cent in the bile period. It is interesting to note that the amount was about the same during this bile period as in the second experiment when the bile was again taking its natural course. …”
Publicado 1901
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264863“…Among the base substitutions, G:C --> T:A, G:C --> A:T and G:C --> C:G were also noticed. Interestingly, NQO1 competed with P450 reductase and specifically prevented the P450 reductase-activated BP-3,6-Q-induced mutations. …”
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264864“…Similarly was IL-10 level (74.13 ± 52.99 vs 2.64 ± 0.92 ng/ml, p < 0.00001) that correlated negatively with T3 (r = -0.512, p < 0.0001) but not T4. Interestingly, both interleukins correlated positively (r = 0.770, p = <0.001). …”
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264865“…In humans and mice, there are two major alternately spliced isoforms of the Moe orthologue, Erythrocyte Protein Band 4.1-Like 5 (Epb4.1l5), which we have named Epb4.1l5(long )and Epb4.1l5(short), that differ after the FERM domain. Interestingly, Moe and both Epb4.1l5 isoforms have a putative C' terminal Type-I PDZ-Binding Domain (PBD). …”
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264866por Brand, Richard A.“…This, he suggested, allowed functional motion within 6 months in the two cases he described. Interestingly, in his “Operative Orthopaedics” published in 1939, he recommends covering the exposed bony surfaces with fascia lata, and does not describe attaching the flap of the triceps to the anterior capsule, but rather suggests attaching “at a lower point than its former attachment to permit free play of the joint in flexion” [3]. …”
Publicado 2008
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264867“…CONCLUSION: The mt-genome of C. hongkongensis shares some similarity with, and interesting differences to, other Crassostrea species and bivalves. …”
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264868por Raji, B., Dansault, A., Vieira, V., de la Houssaye, G., Lacassagne, E., Kobetz, A., Arbogast, L., Dufier, J.L., Blumer, J.B., Menasche, M., Abitbol, M.“…The most striking results obtained concerned the lens, in which mPins protein distribution switched from the anterior to the posterior region of the lens during embryonic development. Interestingly, in the postnatal and adult lens, mPins protein was detected in all lens cells and fibers. …”
Publicado 2008
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264869“…Health care professionals and patients are both interested in utilizing electronic health information. …”
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264870“…We used the values of the clustering coefficient and the transitivity violations to select the optimal choices among those that we tested. Interestingly, this criterion also favours the agreement between automatic and expert classifications. …”
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264871por ten Haaf, Anette, Bektas, Nuran, von Serenyi, Sonja, Losen, Inge, Arweiler, Elfriede Christel, Hartmann, Arndt, Knüchel, Ruth, Dahl, Edgar“…On protein level, nuclear GLI1 expression in breast cancer cells was clearly more abundant than in normal breast epithelial cells (P = 0.008, two-tailed Mann-Whitney U-test) and increased expression of GLI1 protein in breast tumours significantly correlated with unfavourable overall survival (P = 0.019), but also with higher tumour stage (P < 0.001) and an increased number of tumour-positive axillar lymph nodes (P = 0.027). Interestingly, a highly significant correlation was found between GLI1 expression and the expression of SHH, a central upstream molecule of the hedgehog pathway that was previously analysed on the same tissue microarray. …”
Publicado 2009
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264872por Roscioni, Sara S, Kistemaker, Loes EM, Menzen, Mark H, Elzinga, Carolina RS, Gosens, Reinoud, Halayko, Andrew J, Meurs, Herman, Schmidt, Martina“…Treatment of the cells with toxin B-1470 and U0126 significantly reduced bradykinin-induced IL-8 release alone or in combination with the activators of PKA and Epac. Interestingly, inhibition of PKA by Rp-8-CPT-cAMPS and silencing of Epac1 and Epac2 expression by specific siRNAs largely decreased activation of Rap1 and the augmentation of bradykinin-induced IL-8 release by both PKA and Epac. …”
Publicado 2009
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264873por Bozdagi, Ozlem, Sakurai, Takeshi, Papapetrou, Danae, Wang, Xiaobin, Dickstein, Dara L, Takahashi, Nagahide, Kajiwara, Yuji, Yang, Mu, Katz, Adam M, Scattoni, Maria Luisa, Harris, Mark J, Saxena, Roheeni, Silverman, Jill L, Crawley, Jacqueline N, Zhou, Qiang, Hof, Patrick R, Buxbaum, Joseph D“…The reduced glutamatergic transmission that we observed in the Shank3 heterozygous mice represents an interesting therapeutic target in Shank3-haploinsufficiency syndromes.…”
Publicado 2010
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264874por Chapuis, Marie-Pierre, Tohidi-Esfahani, Donya, Dodgson, Tim, Blondin, Laurence, Ponton, Fleur, Cullen, Darron, Simpson, Stephen J, Sword, Gregory A“…We applied their use to studying a target gene that encodes a Ca(2+ )binding glycoprotein, SPARC, which was previously found to be up-regulated in brains of gregarious desert locusts, Schistocerca gregaria. Interestingly, expression of this gene did not vary with rearing density in the same way in brains of the two locust species. …”
Publicado 2011
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264875por McHenry, Peter R, Sears, James C, Herrick, Matthew P, Chang, Peggy, Heckman-Stoddard, Brandy M, Rybarczyk, Megan, Chodosh, Lewis A, Gunther, Edward J, Hilsenbeck, Susan G, Rosen, Jeffrey M, Vargo-Gogola, Tracy“…RESULTS: Altered p190B expression resulted in a two-fold increase in tumor multiplicity and a three-fold increase in metastases compared to control mice indicating that exogenous p190B expression in the mammary epithelium promotes MMTV-Neu mammary tumor formation and progression. Interestingly, non-transformed primary MECs expressing exogenous p190B displayed increased adhesion to laminin and type IV collagen and formed invasive structures in a three-dimensional culture assay. …”
Publicado 2010
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264876“…SCIENCE AND PHILOSOPHY: The insights of philosophy could become heuristic and algorithmic models for scientific experimentation. MATTER: An interesting aspect of Sri Aurobindo's philosophy is his acceptance of the reality of matter even while highlighting its inadequacies; the ultimate goal, according to him, is the divination of matter itself. …”
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264877por Pellino, Marco, Sharbel, Timothy F, Mau, Martin, Amiteye, Samuel, Corral, José María“…The genus Boechera represents an interesting model system for understanding apomixis, having both sexual and apomictic genotypes at the diploid level. …”
Publicado 2011
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264878“…CONCLUSIONS: The findings of these two studies highlight the potential for our new tool to provide a valid measure of older women's social quality of life, yet they require duplication in longitudinal research. Interested clinicians should consider using the OWSQLI in their assessment battery to identify older women's areas of lower versus higher social quality of life, and should establish the maximization of patients' social quality of life as an important therapeutic goal, as this variable is significantly related to both physical and mental health.…”
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264879por Sarkar, Mehuli, Chanda, Shampa, Chakrabarti, Sekhar, Mazumdar, Jaydeep, Ganguly, Anirban, Chadha, Mandeep S, Mishra, Akhilesh C, Chawla-Sarkar, Mamta“…Of 31 A/H1N1 strains, five had PB1-F2 similar to the H3N2 strains; six had non-functional PB1-F2 protein (11 amino acids) similar to the 2009 pandemic H1N1 strains and rest 20 strains had 57 amino acids PB1-F2 protein, similar to concurrent A/H1N1 vaccine strain. Interestingly, three A/H1N1 strains with H3N2-like PB1-F2 protein carried primitive PR8-like NS gene. …”
Publicado 2012
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264880“…METHODS: Smokers were recruited from December 2009 to June 2010 by advertising our study in the mass media and on the Internet. Those interested and motivated to quit smoking within 6 months (N = 1123) were randomly assigned to either the experimental (n = 552) or control group (n = 571). …”
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