“…In a multivariate model of lower leg and upper arm fractures only (controlling for age, gender, and race), higher BMI showed no association with prior fracture (OR 1.00 per 5 kg/m(2), p=0.98, 95% CI 0.78-1.26). Interestingly, subjects with a higher comorbidity index had increased odds of prior fracture (OR 1.23 per 1 point increase, p<0.001, 95% CI 1.12-1.36). …”
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“…His LH and FSH were both in the normal range [LH 0.8 mIU/mL (0.29-4.77 mIU/mL), FSH 3.11 mIU/mL (0.85-8.74 mIU/mL)] but estradiol was low at <2 pg/mL (</= 31 pg/mL) as expected in AD. Interestingly, an elevated 17-hydroxyprogesterone (17-OHP) of 911 ng/dL (16-283 ng/dL) was noted. …”
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“…She also developed symptoms of headaches, anorexia and vomiting. Interestingly, repeat MRI brain was performed but did not show any residual tumor despite persistent biochemical CD. …”
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“…MUT FSH secretion also trended down at midnight by about 40%, although this effect was not significant. Interestingly, stores of FSH at 0400 were significantly increased in MUT pituitaries compared to controls. …”
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“…Notably, comparison to the naïve, non-stretched - stress group indicated that the stress of handling alone appeared to change the expression of many genes including Thra and Thrb. Interestingly, comparisons between stretched and non-stretched + stress groups revealed decreased expression of genes involved in collagen synthesis including Col1a1 and CTGF. …”
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“…E decreased anxiety-like behavior in the open-field test, as E mice entered the center zone more times than V mice (p=0.048). Interestingly, in mice fed a HFD, E decreased Fos expression in the paraventricular hypothalamic nucleus (q<0.1), bed nucleus of the stria terminalis (q<0.05), and the subparafascicular area of the thalamus (q<0.001), suggesting that E protects against HFD-induced anxiety by decreasing neural activity in these specific brain regions. …”
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“…Genetic testing of her diabetic mother, which is currently being pursued, will likely confirm the maternal origin of our patient’s mutation as well suggest an increased risk for our patient to develop DM later in life. Interestingly, she had ketosis at the time of hypoglycemia, which is atypical in HI but has been previously reported in a patient with HI associated with a different HNF1A gene mutation. …”
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“…Earlier in 2018, the patient was started on treatment with&nbsp;Orkambi (lumacaftor/ivacaftor)&nbsp;and then&nbsp;Symdeko (tezacaftor/ivacaftor). Interestingly, subsequently&nbsp;Ms. A&nbsp;noticed an improvement of her blood glucose levels and also started having episodes of hypoglycemia. …”
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“…Biopsy of the liver lesions revealed a high grade metastatic small cell neuroendocrine carcinoma with a mitotic rate of 49/10 HPF and Ki-67 of 70%. Interestingly, the neuroendocrine tumor cells in the liver biopsy did not stain for ACTH. …”
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“…The patient was submitted to a partial right adrenalectomy. Interesting, she did not present total or partial AI after the second surgical procedure. …”
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“…Nevertheless, variants of uncertain significance (VUS, mostly intronic) were found in 11% of our cohort, in which 57% of the individuals that carry a VUS presented familial short stature while 43% were non-familial. Interestingly, the variant c.515+112G>A was identified in 3/33 (9.1%) of SGA patients, but only in 2/143 (1.4%) of ISS patients. …”
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“…Her father was not available for genetic studies. Interestingly, her mother was homozygous for the wild type allele, suggesting that the mother did not transmit a DLK1 allele to the patient in this region. …”
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“…The pretreatment with the EGFR inhibitor AG1478 promoted a decreased (P<0.05) ERK 1/2 phosphorylation in control cells. Interestingly, no EGFR activation was detected in the KO-β-arrestin2 cells. …”
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“…Additionally, the currents through the voltage-gated potassium channel subunits Kv2.1 and 2.2 as well as the KCa1.1 (encoded by Kcnma1 gene) channels were also reduced. Interestingly, beta-cells from βERKO mice did not present such reductions, suggesting that these effects occur mainly via ERβ. …”
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“…The urinary [E]/[F] ratio measured by LC-MS/MS method, was used as an index of renal 11βHSD2 activity. Interestingly, a 60% decrease in the [E]/[F] ratio was observed in hypothyroid patients, corroborating our hypothesis (p<0.05). …”
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“…Ldb1(∆panc)mice died by postnatal day 7 with severe hyperglycemia and hypoinsulinemia due to a drastic islet hormone(+)cell reduction. Interestingly, total pancreatic mass remained unchanged in Ldb1(∆panc)neonates, suggesting that Ldb1 impacts are islet-specific in the pancreas. …”
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“…Average blood glucose concentrations at presentation were 329 + 36 mg/dl, interestingly, 52% of the episodes were euglycemic DKA (euDKA) with blood glucose <300 mg/dl. …”
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“…Both FAOi strongly suppressed the androgen response hallmark (FDR q-val < 0.001) in MDVres cells, and this was associated with a significant upregulation of the ATF3 gene (etomoxir; 30-fold, p<0.001 vs vehicle; ranolazine; 2-fold, p< 0.03). Interestingly, knockdown (KD) of ATF3 with shRNAs resulted in differential responses to FAOi in these genetically-related cells. …”
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“…AAV9 Tau ΔD421 also elicited a unique tau-PSR in vivo, and targeted disruption of SSAT prevented the accumulation of acetylated polyamines and impacted several tau phospho-epitopes. Interestingly, SSAT knockout mice presented with altered behavior in the rotarod task, the elevated plus maze, and marble burying task, thus highlighting the impact of polyamine homeostasis within the brain. …”
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“…Using a stepwise multiple logistic regression analysis, we observed 4 CpGs (cg27655935, cg02000426, cg10184328, and cg23085143) whose methylation levels independently predicted the insulin-resistant state at a higher confidence than that of clinical risk factors typically associated with insulin resistance (i.e., fasting glucose, 120-min oral glucose tolerance test, Framingham Risk Score, and Total to HDL cholesterol ratio). Interestingly, 79 of the 123 CpGs (64%) exhibited remarkably similar levels of methylation as that of hematopoietic stem cells (HSC) in monocytes from IR individuals, implicating epigenetic defects in myeloid differentiation as a possible origin for the methylation landscape underlying the insulin resistance phenotype. …”
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