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265561por Li, Yuanfang, Jin, Wenjiao, Zhai, Bin, Chen, Yi, Li, Guoxi, Zhang, Yanhua, Guo, Yujie, Sun, Guirong, Han, Ruili, Li, Zhuanjian, Li, Hong, Tian, Yadong, Liu, Xiaojun, Kang, Xiangtao“…In addition, 12 common target DE-miRNAs of DE-lncRNAs were found in different comparison groups, some of which were muscle-specific miRNAs, such as gga-miR-206, gga-miR-1a-3p, and miR-133a-3p. Interestingly, the precursors of four newly identified miRNAs were found to be homologous to lncRNAs. …”
Publicado 2021
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265562por Dittmar, Michael S., Altmeppen, Jürgen, Bigalke, Marc U., Niedermirtl, Florian, Zimmermann, Markus“…The nursing home blockade and conflicting financial interests of hospitals posed challenges to the work of the disaster task force medical officers.…”
Publicado 2021
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265563por Videira, Alexandre, Beckedorff, Felipe C., daSilva, Lucas F., Verjovski-Almeida, Sergio“…RESULTS: We show that PVT1 knockdown in androgen-stimulated LNCaP cells caused statistically significant expression upregulation/downregulation of hundreds of genes. Interestingly, PVT1 knockdown caused upregulation of 160 genes that were repressed by androgen, including a significantly enriched set of tumor suppressor genes, and among them FAS, NOV/CCN3, BMF, HRK, IFIT2, AJUBA, DRAIC and TNFRSF21. …”
Publicado 2021
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265564por Wang, Song, Bager, Cecilie L., Karsdal, Morten A., Chondros, Dimitrios, Taverna, Darin, Willumsen, Nicholas“…AG (mOS 13.8 vs 8.5 months, P = 0.009; HR = 0.35; 95% CI 0.16–0.77). Interestingly, high C3M/PRO-C3 ratio predicted for a PFS benefit to PAG vs. …”
Publicado 2021
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265565por D’Alò, Gian Loreto, De Crescenzo, Franco, Amato, Laura, Cruciani, Fabio, Davoli, Marina, Fulceri, Francesca, Minozzi, Silvia, Mitrova, Zuzana, Morgano, Gian Paolo, Nardocci, Franco, Saulle, Rosella, Schünemann, Holger Jens, Scattoni, Maria Luisa“…Antipsychotics were found effective on “restricted and repetitive interests and behaviors” (SMD − 0.21, 95% CI − 0.35 to − 0.07, moderate certainty), “hyperactivity, inattention, oppositional, disruptive behavior” (SMD − 0.67, 95% CI − 0.92 to − 0.42, moderate certainty), “social communication, social interaction” (SMD − 0.38, 95% CI − 0.59 to − 0.16, moderate certainty), “emotional dysregulation/irritability” (SMD − 0.71, 95% CI − 0.98 to − 0.43, low certainty), “global functioning, global improvement” (SMD − 0.64, 95% CI − 0.96 to − 0.33, low certainty), “obsessions, compulsions” (SMD − 0.30, 95% CI − 0.55 to − 0.06, moderate certainty). …”
Publicado 2021
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265566por Sougiannis, Alexander T., Enos, Reilly T., VanderVeen, Brandon N., Velazquez, Kandy T., Kelly, Brittany, McDonald, Sierra, Cotham, William, Chatzistamou, Ioulia, Nagarkatti, Mitzi, Fan, Daping, Murphy, E. Angela“…We also found that glucuronidated emodin peaks at 1 h for both I.P. and P.O. administered emodin and is eliminated by 12 h. Interestingly, female mice appear to metabolize emodin at a faster rate than male mice as evidenced by greater levels of glucuronidated emodin at the 1 h time-point (40 mg/kg for both I.P. and P.O. and 20 mg/kg I.P.) and the 4-h time-point (20 mg/kg I.P.). …”
Publicado 2021
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265567por Tan, Lay Kim, Too, Chun Lai, Diaz-Gallo, Lina Marcela, Wahinuddin, Sulaiman, Lau, Ing Soo, Heselynn, Hussein, Nor-Shuhaila, Shahril, Gun, Suk Chyn, Eashwary, Mageswaran, Mohd-Shahrir, Mohamed Said, Ainon, Mohd Mokhtar, Azmillah, Rosman, Muhaini, Othman, Shahnaz, Murad, Alfredsson, Lars, Klareskog, Lars, Padyukov, Leonid“…Our study also revealed that HLA-DRB1 amino acid at position 96 with histidine residue was negatively associated with the risk of developing ACPA-positive RA in the Indians (OR = 0.48, 95% CI = 0.37–0.62, P(GWAS) = 2.58 × 10(−08)). Interestingly, we observed that HLA-DQB1*03:02 allele was inversely related to the risk of developing ACPA-positive RA in the Malays (OR = 0.17, 95% CI = 0.09–0.30, P(GWAS) = 1.60 × 10(−09)). …”
Publicado 2021
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265568Modified CBT for social anxiety and social functioning in young adults with autism spectrum disorderpor Bemmer, Emily R., Boulton, Kelsie A., Thomas, Emma E., Larke, Ben, Lah, Suncica, Hickie, Ian B., Guastella, Adam J.“…Specifically, social anxiety symptoms decreased (p < .001), and specific subdomains of social functioning improved post-intervention, particularly in social motivation (p = .032) and restricted interests and repetitive behaviours (p = .025). Self-reported symptom improvements also generalised to mood (depression, anxiety and stress; p < .05). …”
Publicado 2021
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265569por Wang, Liang, Sun, Liankang, Liu, Runkun, Mo, Huanye, Niu, Yongshen, Chen, Tianxiang, Wang, Yufeng, Han, Shaoshan, Tu, Kangsheng, Liu, Qingguang“…Importantly, rescue experiments demonstrated that the miR-154-5p/PLAGL2 axis mediated the function of MAPKAPK5-AS1 in HCC cells. Interestingly, we found that hypoxia-inducible factor 1α (HIF-1α), a transcript factor, could directly bind to the promoter to activate MAPKAPK5-AS1 transcription. …”
Publicado 2021
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265570por Choreño-Parra, Jose Alberto, Jiménez-Álvarez, Luis Armando, Ramírez-Martínez, Gustavo, Sandoval-Vega, Montserrat, Salinas-Lara, Citlaltepetl, Sánchez-Garibay, Carlos, Luna-Rivero, Cesar, Hernández-Montiel, Erika Mariana, Fernández-López, Luis Alejandro, Cabrera-Cornejo, María Fernanda, Choreño-Parra, Eduardo Misael, Cruz-Lagunas, Alfredo, Domínguez, Andrea, Márquez-García, Eduardo, Cabello-Gutiérrez, Carlos, Bolaños-Morales, Francina Valezka, Mena-Hernández, Lourdes, Delgado-Zaldivar, Diego, Rebolledo-García, Daniel, Guadarrama-Ortiz, Parménides, Regino-Zamarripa, Nora E., Mendoza-Milla, Criselda, García-Latorre, Ethel A., Rodríguez-Reyna, Tatiana Sofía, Cervántes-Rosete, Diana, Hernández-Cárdenas, Carmen M., Khader, Shabaana A., Zlotnik, Albert, Zúñiga, Joaquín“…CXCL17 was detected in post-mortem lung specimens from patients that died of pandemic influenza A(H1N1) and COVID-19. Interestingly, serum levels of CXCL17 were increased only in patients with pandemic influenza A(H1N1), but not COVID-19 and PTB. …”
Publicado 2021
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265571por Bao, Wenquan, Ao, Dun, Wang, Lin, Ling, Zhihao, Chen, Maoshan, Bai, Yue, Wuyun, Ta-Na, Chen, Junxing, Zhang, Shuning, Li, Fengming“…We next analyzed the differentially expressed genes (DEGs) in the developing seeds. Interestingly, compared to 10DAF the number of DEGs was increased from 4406 in 18DAF to 27,623 in 73DAF. …”
Publicado 2021
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265572por Marofi, Faroogh, Tahmasebi, Safa, Rahman, Heshu Sulaiman, Kaigorodov, Denis, Markov, Alexander, Yumashev, Alexei Valerievich, Shomali, Navid, Chartrand, Max Stanley, Pathak, Yashwant, Mohammed, Rebar N., Jarahian, Mostafa, Motavalli, Roza, Motavalli Khiavi, Farhad“…Until recently, two types of ACTs have been developed and introduced; tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR)-T cells which the latter is the subject of our discussion. It is interesting about engineered CAR-T cells that they are genetically endowed with unique cancer-specific characteristics, so they can use the potency of the host immune system to fight against either solid or liquid cancers. …”
Publicado 2021
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265573por Bargar, Connor, Wang, Wen, Gunzler, Steven A., LeFevre, Alexandra, Wang, Zerui, Lerner, Alan J., Singh, Neena, Tatsuoka, Curtis, Appleby, Brian, Zhu, Xiongwei, Xu, Rong, Haroutunian, Vahram, Zou, Wen-Quan, Ma, Jiyan, Chen, Shu G.“…We anticipate that our streamlined protocol will enable interested laboratories to easily and rapidly implement the αSyn RT-QuIC assay for various clinical specimens from PD and DLB. …”
Publicado 2021
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265574por Guzik, Patrycja, Benešová, Martina, Ratz, Magdalena, Monné Rodríguez, Josep M., Deberle, Luisa M., Schibli, Roger, Müller, Cristina“…PURPOSE: The folate receptor (FR) is frequently overexpressed in a variety of tumor types and, hence, an interesting target for radionuclide therapy. The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their properties with those of the previously established folic acid-based [(177)Lu]Lu-OxFol-1. …”
Publicado 2020
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265575por Xu, Tieshan, Xu, Zijie, Lu, Lizhi, Zeng, Tao, Gu, Lihong, Huang, Yongzhen, Zhang, Shunjin, Yang, Peng, Wen, Yifan, Lin, Dajie, Xing, Manping, Huang, Lili, Liu, Guojun, Chao, Zhe, Sun, Weiping“…GO and KEGG analysis showed that DMGs were highly related to cellular and metabolic process and that most DMGs were enriched in muscle-related pathways including Wnt signaling pathway, mTOR signaling and FoxO signaling pathway. Interestingly, a negative correlation between m6A methylation level and mRNA abundance was found through the analysis of m6A-RNA and RNA-seq data. …”
Publicado 2021
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265576por Newman, Tiffany M., Shively, Carol A., Register, Thomas C., Appt, Susan E., Yadav, Hariom, Colwell, Rita R., Fanelli, Brian, Dadlani, Manoj, Graubics, Karlis, Nguyen, Uyen Thao, Ramamoorthy, Sivapriya, Uberseder, Beth, Clear, Kenysha Y. J., Wilson, Adam S., Reeves, Kimberly D., Chappell, Mark C., Tooze, Janet A., Cook, Katherine L.“…However, diet and adiposity must be considered together when analyzing changes in abundance of specific bacterial taxa. Interestingly, P. copri appears to mediate metabolic dysfunction in Western diet-fed NHPs. …”
Publicado 2021
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265577por Shapiro, Maren, Romanski, Phillip, Thomas, Ann, Lanes, Andrea, Yanushpolsky, Elena“…CONCLUSIONS: The dual trigger group had a better prognosis based on age and AMH levels and had better stimulation outcomes, but significantly worse pregnancy outcomes, suggesting the low dose hCG (1000u) in the dual trigger may not have provided adequate luteal support, compared to an hCG-only trigger (10,000u hCG/250-500 μg Ovidrel). Interestingly, the pregnancy rates were comparable in subsequent frozen cycles, further supporting the hypothesis that the issue lies in inadequate luteal phase support, rather than embryo quality. …”
Publicado 2021
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265578por De Pascale, Gennaro, De Maio, Flavio, Carelli, Simone, De Angelis, Giulia, Cacaci, Margherita, Montini, Luca, Bello, Giuseppe, Cutuli, Salvatore Lucio, Pintaudi, Gabriele, Tanzarella, Eloisa Sofia, Xhemalaj, Rikardo, Grieco, Domenico Luca, Tumbarello, Mario, Sanguinetti, Maurizio, Posteraro, Brunella, Antonelli, Massimo“…Species diversity was lower in COVID-19 than in non COVID-19 patients (94.4 ± 44.9 vs 152.5 ± 41.8; p < 0.01). Interestingly, we found that S. aureus (log(2) fold change, 29.5), Streptococcus anginosus subspecies anginosus (log(2) fold change, 24.9), and Olsenella (log(2) fold change, 25.7) were significantly enriched in the COVID-19 group compared to the non–COVID-19 group of SA-VAP patients. …”
Publicado 2021
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265579“…RESULTS: DHM ameliorated liver fibrosis in C57BL/6 mice, as characterized by decreased serum alanine transaminase and aspartate transaminase levels, decreased expressions of collagen I alpha 1 (CoL-1α1), collagen I alpha 2 (CoL-1α2), tissue inhibitor of metalloproteinases 1 (TIMP-1), α-smooth muscle actin (α-SMA) and desmin, as well as increased expression of matrix metalloproteinase 1 (MMP1). Interestingly, HSCs activation was significantly inhibited by DHM in vivo and in vitro. …”
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265580por Ii, Alexandra N., Lin, Shih-Chao, Lepene, Benjamin, Zhou, Weidong, Kehn-Hall, Kylene, van Hoek, Monique L.“…Nanotraps were capable of increasing Y. pestis nucleic acid yield by fourfold from whole human blood compared to standard nucleic acid extraction. Interestingly, we found CN3080 Nanotraps to have a high affinity for multiple components of the Yersinia type III secretion system (T3SS), including chaperone proteins, Yop effector proteins and virulence factor protein LcrV (V). …”
Publicado 2021
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