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  1. 265721
    “…RESULTS: In study 1, most Indonesian university students (240/248, 96.8%) reported openness to an internet-delivered mindfulness program. Most of interested students (127/240, 52.9%) preferred the length of the program to be 3 to 4 sessions, with 45.8% (110/240) preferring brief lessons taking only 15 to 30 minutes to complete. …”
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    Culturally Adapting an Internet-Delivered Mindfulness Intervention for Indonesian University Students Experiencing Psychological Distress: Mixed Methods Study
  2. 265722
    “…Although metastatic tumors had higher levels of all tumor markers, when restricting survival analysis to 1080 patients with metastatic disease elevated CEA, CA19–9 or CA125 were all still associated worse survival (HR vs. normal : 3.4, 1.8, 3.9, p<0.0001 for CEA and CA125, p=0.0019 for CA19–9). Interestingly tumor grade was not associated with CEA or CA19–9 level, while CA-125 was slightly higher in high relative to low-grade tumors (18.3 vs. 15.0, p=0.0009). …”
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    The Clinical Significance of CEA, CA19–9, and CA125 in Management of Appendiceal Adenocarcinoma
  3. 265723
    “…However, no similar relationship was observed for the A1298C polymorphism. Interestingly, significantly increased cancer risk was observed in individuals with C677T genetic variants who were nondrinkers, but not among drinkers. …”
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    Influence of MTHFR polymorphism, alone or in combination with smoking and alcohol consumption, on cancer susceptibility
  4. 265724
    “…Discussion: The incidence of diabetes mellitus after acute pancreatitis depends on the severity of pancreatic necrosis; the degree of insulin deficiency being directly proportional to the extent of necrosis.[1] The pathophysiology of splenic vein thrombosis revolves around necrosis, venous stasis, and activation of coagulation cascade, all in the background of the inflammatory state.[2] Anticoagulation in splenic vein thrombosis secondary to pancreatitis thus remains controversial, given the increased risk of hemorrhage and formation of pseudoaneurysms. Interestingly, therapeutic anticoagulation might prevent thrombosis progression by reducing portal pressure and thereby decreasing the risk of hemorrhage. …”
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    THU365 Diabetic Ketoacidosis Unmasking Acute Pancreatitis With A Hidden Surprise
  5. 265725
    “…Adipocyte sizing analysis showed that GH resistance resulted in a trend towards increased cell sizes in human subcutaneous (SubQ) and visceral (Visc) depots, and a significant increase in pig Visc. Interestingly, the human adipocyte size histogram was similar to that of the pig across genotypes and depots. …”
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    THU051 GH Resistance And Adipose Tissue: Multispecies Measurement Of Morphology And Transcriptome
  6. 265726
    “…Since it would be expected that cooking high cholesterol foods, such as bacon, under oxidative conditions, such as pan-frying, would produce fat containing cancer-promoting cholesterol metabolites, we hypothesized that consumption of such cooked foods would also promote reemergence from dormancy. Interestingly, consumption of cured, fried bacon fat (cfBF), but not uncured fried bacon fat (ufBF) resulted in reemergence. …”
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    THU485 The Impact Of Cured, Fried Bacon On The Reemergence From Breast Cancer Dormancy
  7. 265727
    “…In that context, most ER antagonists, especially the SERDs, show very little gene activation. We were interested in understanding antagonist mechanism of action in asynchronous cells that were growing in intact medium that had not been charcoal-stripped to remove estradiol and growth factors. …”
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    OR11-01 A New Model for Estrogen Receptor-alpha Antagonist Mechanism of Action
  8. 265728
    “…Male Icer KO mice 14 days post-gonadectomy (GDX) had significantly more LH pulses within a three-hour period than controls (Icer KO 5.83 ± 0.4 pulses vs Icer(fl/fl) 4.66 ± 0.3 pulses; p=0.049), but no differences in basal LH or LH pulse amplitude. Interestingly, serum FSH levels were significantly lower in Icer KO mice compared to Icer(fl/fl) controls 2 days post-GDX (Icer KO 20.0 ± 1.0 vs Icer(fl/fl) 26.0 ± 0.8; p=0.003) and 7 days post-GDX (Icer KO 18.0 ± 0.4 vs Icer(fl/fl) 22.5 ± 0.8, p=0.002). …”
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    SAT608 Gonadotrope-specific Deletion Of Icer Results In Increased Lh Pulsatility But Reduced Fsh Levels In Mice
  9. 265729
    “…Renal Glut2 knockout mice have improved glucose tolerance and are protected from high-fat diet or streptozocin-induced diabetes because they excrete excess blood glucose in urine. Interestingly, despite the profound loss of glucose in urine, renal Glut2 knockout mice have normal fasting blood glucose levels. …”
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    THU123 Knockout Of Renal Glut2 Gene Activates The Hypothalamic-pituitary-adrenal Axis To Increase Glucose Production In Mice
  10. 265730
    “…However, she was started on Mg since her first hospitalization despite normal serum Mg levels. Interestingly, her 24-hour urine studies revealed FeMg of 6.5% suggestive of renal Mg wasting. …”
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    SAT219 Severe Isolated Hypocalcemia With Cetuximab & Irinotecan Chemotherapy
  11. 265731
    por Wiepjes, Chantal, Heijer, Martin Den
    Publicado 2023
    “…For further research it is interesting to see whether the severity of autoimmune diseases changes in trans people starting gender-affirming hormones. …”
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    SAT416 The Incidence Of Autoimmune Disease In Transgender People After Initiation Of Gender-Affirming Hormone Therapy
  12. 265732
    “…Cells expressing respectively CYP11B1 and CYP11B2 were found interwoven at different levels: i) single or cluster of CYP11B2 cells can be observed in the inner cortex surrounded by CYP11B1-expressing cells (33/47, 70.21%) and ii) the two type of cells might be found in the same nest or basket of cells beneath the capsule (40/47 donors, 85.10%). Interestingly, CYP11B1 and CYP11B2 cells were also present within the ZR. …”
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    OR08-03 Ectopic Localization Of CYP11B1 and CYP11B2-Expressing Cells In The Normal Human Adrenal Gland
  13. 265733
    “…ARH(kisspeptin) neurons recorded from male mice exhibited RPM average of -55.6±1.5 (-45 to -66 mV) and IR of 1.5±0.15 GΩ (n= 13 cells out of 10 mice). Interestingly, NPY induced no effect on RMP, IR, or fAPs in male animals. …”
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    SAT592 Sexually Dimorphic Modulation Of Arcuate Kisspeptin Neurons Activity In Response To NPY
  14. 265734
    “…This case of osteomalacia resulting from Vitamin D deficiency and subsequent secondary hyperparathyroidism demonstrates that it is imperative to recognize and treat Vitamin D deficiency because it restores bone strength and prevents fractures while simultaneously correcting biochemical abnormalities (1). This case is also interesting as the patient still carries an increased risk of bone density loss complicated by underlying premature ovarian insufficiency and hypoestrogenic state. …”
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    THU440 A Case Of Osteomalacia In A Young Adult Female With Premature Ovarian Insufficiency
  15. 265735
    “…Introduction: Humoral hypercalcemia of malignancy is known to be associated with squamous cell carcinomas (SCC), although rarely seen in the setting of skin cancer. We present an interesting case of a young patient with giant condyloma acuminatum complicated by SCC presenting with severe hypercalcemia. …”
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    SAT256 Buschke Loewenstein Tumor Presenting With Hypercalcemia
  16. 265736
    “…It is possible that dual incretin therapy may attenuate more of the post-prandial hyperinsulinemic-hypoglycemic response in ways that are incompletely understood and requires further investigation. Interestingly, this case showed that tirzepatide administration not only resulted near-resolution of post-prandial hypoglycemia, but it also improved this patients’ early dumping syndrome symptoms. …”
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    FRI612 Tirzepatide For The Treatment Of Post-bariatric Surgery Hypoglycemia And Early Dumping Syndrome
  17. 265737
    “…Interpretation/Conclusions: Over all the results for the patients on the questionnaires showed a similar pattern with increasing signs of stress vulnerability with milder genotype and increasing, but deficient, metanephrine levels. An interesting finding was that a total epinephrine deficiency, as in null genotype, with less somatic effects of stress (increased heart rate etc), may be beneficial for some aspects of perceived stress tolerance. …”
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    SAT284 Is Stress Vulnerability In CAH Related To Epinephrine Deficiency And CYP21A2 Genotype?
  18. 265738
    “…Additionally, endogenous PTHrP production by breast and placental tissue have also been described as rare causes of hypercalcemia in pregnancy. We describe an interesting case of severe hypercalcemia in a pregnant woman presenting with acute fatty liver of pregnancy (AFLP) which rapidly corrected after delivery. …”
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    THU473 Acute Hypercalcemia In The Setting Of Acute Fatty Liver Of Pregnancy, A Case Report
  19. 265739
    “…In the tumor cell population, genes involved in hormone secretion regulation, such as SCG2, VGF, TIMP1, NNAT, and CALD1 were reduced in CBG-treated samples, consistent with the inhibitory effects of CBG on PRL hormone processing and secretion. Interestingly, we also observed a reduction in MHC-I complex HLA-A and B2M expression concomitant with an increase of CD8+ T cells in the CBG-treated PRL-oma samples. …”
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    FRI294 The Dopamine Agonist Cabergoline Targets Multiple Pathways To Inhibit PRL Secretion And Increases Stromal Fibrosis Via The Serotonin Receptor 5HTR1F
  20. 265740
    “…Autoimmune manifestations occur in 22% of CVID patients and these include autoimmune cytopenia, pernicious anemia, rheumatoid arthritis, vitiligo, and/or HT. Interestingly, our patient did not manifest any thyroid Abs thus it may be postulated that thyroid follicles destruction in HT is mediated predominantly by thyroid-specific B and T cells rather than by thyroid antibodies. …”
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    FRI568 Hashimoto’s Thyroiditis With Negative Antibodies In Association With Common Variable Immunodeficiency
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