“…Single miRNAs generally exhibited low AUC values with the highest values for miR-874-3p and miR-501-5p which in combination provided an interesting value (AUC = 0.782). Pearson’s analysis confirmed that miR-10b-5p, miR-215-5p, miR-501-5p, miR-551a, and miR-874-3p significantly correlated with BMI z-score. …”
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“…Furthermore, significantly more women regarded it as an alternative prior to seeing a doctor when they perceived a decline in fetal movements (P<.001). Interestingly, women with university degrees had a higher propensity to engage in pregnancy self-monitoring compared with women without one (37% vs 23%; P=.001). …”
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“…For all biomarkers examined, cigarette users had the highest GMs compared to other tobacco-product users. Interestingly, GMs of 2-hydroxyfluorene, 3-hydroxyfluorene and Σ2,3-hydroxyphenanthrene were significantly higher in SLT users than in e-cigarette users; 3-hydroxyfluorene and 1-hydroxypyrene were also significantly higher in e-cigarette and SLT users than in never users. …”
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“…Of these, we focused in the study of functional relationships between miR-643, upregulated at 45 min interaction, and its predicted target X-linked inhibitor of apoptosis protein (XIAP). Interestingly, interplay of amoeba with SW-480 cells resulted in downregulation of XIAP consistent with apoptosis activation. …”
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“…On the other hand, 596 genes were decreased more than 2-fold, 6 genes more than 20-fold. Interestingly, among these genes upregulated more than 2-fold, 6 driver genes (FANCI, NCAPD3, NCAPG, OXCT1, EPHA1 and MCM2) were formerly reported as driver oncogenes. …”
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“…GSK3B after acute RE). Interestingly, 51 genes were also identified to be up/downregulated in both the acute and chronic RE pooled transcriptome analysis as well as significantly hypo/hypermethylated after acute RE, chronic RE, detraining and retraining. …”
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“…In agreement, insulin secretion was severely perturbed in isolated islets, and both first- and second-phase insulin release were lowered compared with control rats, while glucagon secretion was similar in both groups. Interestingly, after 5–7 days of culture of islets from DRLyp/Lyp rats in normal media, glucose-stimulated insulin secretion (GSIS) was improved; although, a significant decrease in GSIS was still evident compared with islets from control rats at this time (7393.9 ± 1593.7 vs 4416.8 ± 1230.5 pg islet(−1) h(−1); p < 0.0001). …”
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“…Altogether, these observations signify the uniqueness in Indian CLCuMuV isolates showing contribution of CLCuKoV in all the genes. An interesting observation was frequent identification of GLCuA in CLCuD leaf samples. …”
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“…Expressions of JAK(1,2,)、 STAT(3) 、PD-L1 and ATM were increased in A549CisR and H157CisR cells and could by induced by cisplatin in parental lung cancer cells. Interestedly, ATM upregulated PD-L1 expression via JAK(1,2)/STAT(3) pathway and inhibition of ATM decreased JAK/STAT3 signaling and decreased PD-L1 expression. …”
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“…Analysis of EMD revealed two previously identified variants associated with adult-onset cardiomyopathy (p.K37del, p.E35K) and one deemed ‘benign’ in an Emery-Dreifuss patient (p.D149H). Interestingly p.D149H was the most frequent emerin variant in ExAC, identified in 58 individuals (overall allele frequency 0.06645%), of whom 55 were East Asian (allele frequency 0.8297%). …”
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“…Moreover, lower MacroH2A1.1 and QKI expression levels associated with less differentiated tumors (Gleason score ≥ 7). Interestingly, MacroH2A1.1, but more impressively DDX17 (AUC = 0.93; p < 0.0001) and QKI (AUC = 0.94; p < 0.0001), accurately discriminated cancerous from noncancerous prostate tissues. …”
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“…Additionally, she required intermittent IV calcium gluconate boluses for symptomatic hypocalcemia. Interestingly, post op iPTH was low but not in line with the severity of hypocalcemia (14.9-17pg/ml). …”
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“…It provides pubertal hormonal suppression for 1 year and needs to be replaced yearly. We present an interesting case of a forgotten Histrelin implant which was not removed for 5 years. …”
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“…However, aHepPPARγKO reduced steatosis in HFCFD-fed mice, but not in MCD-fed mice. Interestingly, the levels of hepatic oleic [18:1(n-9)] and linoleic [18:2(n-6)] acids were, in fact, increased in MCD-fed aHepPPARγKO mice, while the levels of hepatic palmitoleic [16:1(n-7)] and oleic [18:1(n-9)] acids were reduced in HFCFD-fed aHepPPARγKO mice. …”
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“…DM was significantly associated with the incidence of MOF only in CA and HIS (HR 1.24, 95% CI 1.03-1.49, p=0.02) but not in AA (HR 0.92, 95% CI 0.68-1.23, p=0.56). Interestingly, the association between MOF and prior fracture was far stronger in AA (HR 10.09, 95% CI 5.14-19.81, p<0.001) than in CA and HIS (HR 2.03, 95% CI 1.01-4.09, p=0.048). …”
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“…An increase in D2, and the subsequent T3 generated, is required for normal muscle stem cell (MuSC) differentiation during muscle repair [1]. Interestingly, crosstalk between MuSC and endothelial cells via vascular endothelial growth factor (VEGF) is critical for proper muscle regeneration. …”
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“…In PLN, a site for islet antigen-specific T cell activation and recruitment in case of pancreas autoimmunity, flow cytometry data revealed that late weaning leads to enrichment of Tregs and consequently regulation of cytotoxic CD8 T lymphocytes (CTLs). Most interestingly, late weaning enriched the Treg population at the spleen level too. …”
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“…They can secrete “big” IGF-2, which can activate insulin receptors to inhibit glucose output from the liver and increase uptake in muscle and adipose tissue leading to hypoglycemia. Interestingly, the IGF-2 level is not always outside the normal range, but a ratio of IGF-2/IGF-1 greater than 10 can be another marker of paraneoplastic hypoglycemia. …”
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“…She credibly insists on full compliance with her L-T4 therapy, never taking the medication within an hour of having breakfast or taking her other medications, which included ferrous sulfate and SC/CA. Interestingly, the highest TSH level recorded before starting SC/CA was only 24.9, associated with a low FT4 level of 0.66. …”
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“…Desmopressin and hypertonic saline can be effectively used to prevent or stop rapid sodium correction. An interesting feature about this case is that partially empty sella is the cause for hypopituitarism.…”
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