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265941“…Hence, DT is comparable in efficacy, but safer compared to TT. This interesting hypothesis will have to be confirmed in future studies.…”
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265942por Joshi, Tripti, Gupta, Ruta, Olaya A, Luisa Fernanda, Yu, Bing, McLennan, Susan, Chua, Elizabeth Lian“…There was no significant association between PD-L1 tumour status and clinicopathologic outcomes. Interestingly, majority of multifocal, bilateral and both bilateral and multifocal PTC were PD-L1 negative (85%,69% and 69% respectively, P<0.05); only extrathyroidal extension was found to be associated with positive (≥1%) PD-L1 staining (83.3 vs.30.8; p=0.057). …”
Publicado 2021
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265943por Vazquez Borrego, Maria del Carmen, Moreno, Mercedes del Rio, Sarmento-Cabral, Andre, Mahmood, Mariyah, Subbaiah, Papasani V, Yakar, Shoshana, Cordoba-Chacon, Jose, Puchowicz, Michelle, Kineman, Rhonda D“…Remarkably, IGF1 reconstitution had no major impact on the hepatic transcriptome of aHepGHRkd mice, with the exception of reducing the expression of Srebf1, consistent with the reduction in circulating insulin levels. Interestingly, carbohydrate-responsive element-binding protein (CHREBP) levels, but not mRNA levels, were greater in aHepGHRkd mice with or without IGF1 reconstitution, consistent with upregulation of CHREBP target genes (Khk and Fasn among others). …”
Publicado 2021
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265944por Bukhari, Khulood, Huang, Huei-Kai, Hung, Duan-Pei, Peng, Carol Chiung-Hui, Shih, Ming-Chieh, Chang, Rachel Huai-En, Tu, Yu-Kang, Munir, Kashif M“…We demonstrated a J-shaped curve, indicating that both underweight and obese patients had a higher mortality than those with normal weight. Interestingly, overweight patients (BMI, 25−30 kg/m(2)) seemed to have the lowest mortality risk. …”
Publicado 2021
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265945“…As this patient was interested in future fertility, additional studies to further investigate her AMH production were carried out. …”
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265946“…In contrast, in OVX+E mice, 3xCORT significantly slowed the frequency of LH pulses (pulses/90 min: 2.7±0.2 vs 1.4±0.3; pre vs post, p<0.05) compared to mice given 3xSaline (pulses/90 min: 2.9±0.4 vs 2.8±0.4; pre vs post, p>0.05). Interestingly, in OVX mice, there was no impairment of LH secretion in response to either 3xCORT (pulses/90 min: 4.9±0.4 vs 4.7±0.5; pre vs post, p>0.05) or 3xSaline. …”
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265947“…Based on her MRI findings, the most likely mechanism in this case was infundibular/hypothalamic infiltration. Her adypsia is interesting and may point to more generalized hypothalamic involvement including thirst center. …”
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265948“…Post-operatively, TSH had dropped from 6.534 to 0.002 IU/mL (n 0.4-5 IU/mL) and Free T4 had dropped from 3.1 to 0.5 ng/dL (n 0.6-1.2 ng/dL). Interestingly, immunohistochemical staining was negative for TSH but the specimen did show histologic features characteristic of TSH-producing adenoma including extensive stromal fibrosis and nuclear pleomorphism. …”
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265949“…Those who were diagnosed with knee osteoarthritis and underwent primary unilateral or one‐stage bilateral TKA by using PFC Sigma PS150 (closed‐box prosthesis) or Vanguard (open‐box prosthesis) knee systems and had complete data of laboratory indexes on postoperative day (POD) 1, POD 3, and POD 5 were the interested population. At last 243 patients were enrolled, among which 88 patients were classified into the unilateral closed‐box group, 66 patients into the unilateral open‐box group, 47 patients into the one‐stage bilateral closed‐box group, and 42 patients into the one‐stage bilateral open‐box group. …”
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265950“…Among the upregulated DEmiRNAs, miR-3568 was especially interesting. While SCII causes severe neurological deficits of lower extremities, the anti-miRNA oligonucleotides (AMOs) of miR-3568 improve neurological function. …”
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265951por Cao, Gabriel, González, Julián, Ortiz Fragola, Juan P., Muller, Angélica, Tumarkin, Mariano, Moriondo, Marisa, Azzato, Francisco, Blanco, Manuel Vazquez, Milei, José“…Accordingly, a reduced mean value of islet α and β cell number per body weight (0.05±0.02 and 0.08±0.04 respectively; both p<0.05) compared to W was detected. Interestingly, consumption of light cola increased the Vi (10.7±3.6; p<0.05) compared to W. …”
Publicado 2021
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265952por Zhu, Tracy Y, Rothenbühler, Martina, Hamvas, Györgyi, Hofmann, Anja, Welter, JoEllen, Kahr, Maike, Kimmich, Nina, Shilaih, Mohaned, Leeners, Brigitte“…CONCLUSIONS: For women interested in maximizing the chances of pregnancy, wrist skin temperature continuously measured during sleep is more sensitive than BBT for detecting ovulation. …”
Publicado 2021
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265953“…Insulinoma, which is less common and is seen in only 10-30% patients, needs documentation of Whipple’s triad. Interestingly, our patient never had any history of hypoglycemia.…”
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265954por Hernández-Ramírez, Laura C, Pankratz, Nathan, Lane, John, Hu, Mingming, Faucz, Fabio R, Chittiboina, Prashant, Denise, Kay M, Mills, James L, Stratakis, Constantine A“…Overexpression of the p.M194L variant caused phospho-CREB S133 activation, suggesting increased GEF activity for this variant. Interestingly, another variant at the same position, p.M194I, was found in the COSMIC database (COSS2121715) as a somatic change in cutaneous malignant melanoma. …”
Publicado 2021
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265955por Nigam, Manas, Kim, Kevin G., Harbour, Patrick, Dekker, Paige K., Zolper, Elizabeth G., Abu El Hawa, Areeg A., CO, Ivy, Patel, Jay, Attinger, Christopher E., Razmjou, Kasra A., Kleiber, Grant M.“…Use of regional anesthesia, with TMR, provided an additive effect, significantly decreasing postoperative opioid use by 124.3 MME, compared to control (p<0.0001). Interestingly, regional anesthesia without TMR decreased postoperative opioid use by 93.4 MME, but without significance (p=0.08). …”
Publicado 2021
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265956por Barten, Danique L.J., Laan, Janna J., Nelissen, Koen J., Visser, Jorrit, Westerveld, Henrike, Bel, Arjan, de Jonge, Catharina S., Stoker, Jaap, van Kesteren, Zdenko“…In addition, the developed technique can be a very interesting application for bowel motility assessment in diagnostic radiology.…”
Publicado 2021
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265957por Liu, Huaize, Ding, Jie, Köhnlein, Karl, Urban, Nadine, Ori, Alessandro, Villavicencio-Lorini, Pablo, Walentek, Peter, Klotz, Lars-Oliver, Hollemann, Thomas, Pfirrmann, Thorsten“…ABBREVIATIONS: ACTB: actin, beta; ADP: adenosine diphosphate; AMP: adenosine monophosphate; AMPK: AMP-activated protein kinase; ARMC8: armadillo repeat containing 8; ATP: adenosine triphosphate; BafA1: bafilomycin A(1); BCAA: branched chain amino acid; BICC1: BicC family RNA binding protein 1; BSA: bovine serum albumin; CAMKK2 kinase: calcium/calmodulin dependent protein kinase kinase 2, beta; CHX: cycloheximide; DMEM: Dulbecco’s modified Eagle’s medium; E1: ubiquitin-activating enzyme; E2: ubiquitin-conjugating enzyme; E3: ubiquitin ligase; ECAR: extracellular acidification rate; FACS: fluorescent associated cell sorter; FBP1: fructose-bisphosphatase 1; FCCP: carbonyl cyanide-4 (trifluoromethoxy) phenylhydrazone; G6P: glucose-6-phosphate; GDP: guanosine diphosphate; GFP: green fluorescent protein; GID: glucose induced degradation deficient; GMP: guanosine monophosphate; GTP: guanosine triphosphate; HBP1: high mobility group box transcription factor 1; HPRT: hypoxanthine guanine phosphoribosyl transferase; KO: knock out; LE: long exposure; MAEA: macrophage erythroblast attacher; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MKLN1: muskelin 1; mRNA: messenger RNA; MTOR: mechanistic target of rapamycin; NES: normalized enrichment score; OCR: oxygen consumption rate; PBS: phosphate buffered saline; PCK1: phosphoenolpyruvate carboxykinase 1, cytosolic; PCR: polymerase chain reaction; PFA: paraformaldehyde; RANBP9: RAN binding protein 9; RING: really interesting new gene; RMND5: required for meiotic nuclear division5 homolog; RPS6: ribosomal protein S6; RPTOR: regulatory associated protein of MTOR, complex 1; SE: short exposure; SEM: standard error of the mean; SQSTM1/p62: sequestosome 1; TSC2: tuberous sclerosis complex 2; TUBA4A: tubulin; TUBE: tandem ubiquitin binding entities; Ub: ubiquitin; UPS: ubiquitin proteasome system; WDR26: WD repeat domain 26; WT: wild type.…”
Publicado 2019
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265958“…BACKGROUND: Increasing evidence shows that circular RNAs (circRNAs) play a key role in the development of colorectal cancer (CRC). An interesting candidate RNA in this context is hsa-circRNA-0067835 (circIFT80), but its network of actions is still unclear. …”
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265959por Sun, Na-Na, Zhang, Yue, Huang, Wen-Hui, Zheng, Bo-Jun, Jin, Si-Yi, Li, Xu, Meng, Ying“…The exosomes were taken by fibroblasts and resulted in higher levels of AT1R (0.22 ± 0.02 vs. 0.07 ± 0.02, t = 8.66, P = 0.001), TGF-β (0.54 ± 0.05 vs. 0.09 ± 0.06, t = 10.00, P < 0.001), p-Smad2/3 (0.58 ± 0.06 vs. 0.07 ± 0.03, t = 12.86, P < 0.001) and α-collagen I (0.27 ± 0.02 vs. 0.16 ± 0.01, t = 7.01, P = 0.002), and increased Ang II secretion (62.27 ± 7.32 vs. 9.56 ± 1.68, t = 12.16, P < 0.001). Interestingly, Ang II increased the number of macrophage exosomes, and the protein levels of Alix (1.45 ± 0.15 vs. 1.00 ± 0.10, t = 4.32, P = 0.012), AT1R (4.05 ± 0.64 vs. 1.00 ± 0.09, t = 8.17, P = 0.001), and glyceraldehyde-3-phosphate dehydrogenase (2.13 ± 0.36 vs. 1.00 ± 0.10, t = 5.28, P = 0.006) were increased in exosomes secreted by the same number of macrophages, indicating a positive loop between Ang II and exosomes production. …”
Publicado 2021
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265960por da Silva Rosa, Simone C., Martens, Matthew D., Field, Jared T., Nguyen, Lucas, Kereliuk, Stephanie M., Hai, Yan, Chapman, Donald, Diehl-Jones, William, Aliani, Michel, West, Adrian R., Thliveris, James, Ghavami, Saeid, Rampitsch, Christof, Dolinsky, Vernon W., Gordon, Joseph W.“…To provide a better understanding of this observation, we undertook gene expression array and shot-gun metabolomics studies in soleus muscle from rodents on an HF diet. Interestingly, we observed a modest reduction in several autophagy-related genes. …”
Publicado 2020
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