“…In addition, this fungal interaction significantly induced an augmented expression of IL-6 and a decrease in the expression of IL-1β, IL-17, TNF-α, TGF-β, as well as the immune mediators Arg-1 and iNOS. Interestingly, blockade of these receptors did not affect phagocytosis, but increased IL-1β, IL-17, and TNF-α expression and reduced the expression of IL-6. …”
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“…X-rays reviewed by radiology specialist interestingly showed significant erosive disease as well as unexpectedly some subluxation that appeared more like RA than PsA. …”
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“…Because the evidence is mixed, it becomes interesting to examine the processes that provide insight in how stuttering may affect self‐esteem. …”
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“…In a few instances, it also detected rare molds in culture-negative samples and multiple Aspergillus spp. within one BAL sample, a phenomenon that has been previously described in cultures. Interestingly, there was no clear correlation between dHRM results and BAL galactomannan levels, suggesting that dHRM may serve as an independent method allowing for a combined diagnostic approach. …”
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“…Our findings indicated that an elevated sHER2 was an unfavorable prognostic factor in breast cancer. More interestingly, sHER2 ECD was found to be a promising biomarker for predicting adverse clinical outcomes of trastuzumab-based treatment but did not affect the efficacy of tyrosine kinase inhibitors. …”
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“…However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively). …”
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“…The patient and parent, if interested, were randomized to receive the SOVA websites and enhanced usual care (EUC) compared with EUC alone. …”
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“…Importantly, at 25 weeks of age 70% of RI-CT treated mice were protected from the development of diabetes, while as expected 80% of control NOD mice had developed the disease. Interestingly, RI-CT injection also altered T-cell subpopulations in NOD mice significantly decreasing CD8 expression and significantly increasing Foxp3 levels in treated mice. …”
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“…Most recent laboratory results showed: HbA1c >14% (<5.7%), fasting plasma glucose 419 mg/dL (70-99 mg/dL), c-peptide <0.10 ng/mL (0.80-3.85 ng/dL), and GAD65 Ab 18 IU/mL (<5 IU/mL). Interestingly patient also had a decreased leptin of 0.5 ng/mL (1.8-19.9 ng/mL), a known feature of lipodystrophy. …”
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“…Upon HFD feeding, CCN5 knockout mice gained similar amounts of weight as their wild-type counterparts (male 2.0 vs. 1.9-fold; female 2.7 vs. 2.4-fold) but demonstrated sexual dimorphic changes in insulin sensitivity. Interestingly, male knockout mice displayed significant improvements in insulin sensitivity and glucose tolerance, despite being equally obese as their wild-type controls. …”
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“…CT brain showed diffuse subarachnoid blood with CTA showing an elongated saccular aneurysm measuring 2.57×1.72×1.85 mm.Hypercalcemia and AKI resolved with hydration. Interestingly, corrected calcium remained in the low-normal range between 8.6 - 8.8 (8.5-10.2 mg/dL), throughout 10 days of hospitalization despite holding all calcium citrate and calcitriol supplements, which were also held on discharge. …”
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“…The presence of concurrent PTH and non PTH mediated etiology of hyperca makes this case an interesting one and showcases that multifactorial etiologies of hyperca can coexist. …”
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“…We also observed a significant reduction in malonyl CoA levels in ND 646 and metformin cotreated embryos with glucose compared to controls. Interestingly, quantification of ORO staining revealed a significant increase in lipid deposition in glucose treated embryos compared to controls at 120 hpf (0.2±0.01 vrs 0.13±0.005), which was significantly attenuated in embryos co-treated with glucose and 2-DG- (0.15±0.003) or metformin- (0.11±0.007) compared to glucose-treated embryos. …”
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“…Our patient presents as an interesting case of AST from K. Pneumoniae with hematogenous spread that precipitated a thyroid storm. …”
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“…INTRODUCTION: Primary bilateral macro-nodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing's syndrome, characterized by a high clinical heterogeneity, both with regards to the severity of cortisol excess and the morphologic appearance of the adrenals. We present an interesting case of Cushing's syndrome caused by Primary bilateral macro-nodular adrenal hyperplasia. …”
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“…Accordingly, meta-regression data have shown that the sperm count has halved in the past forty years worldwide for no apparent reason. Interestingly, the prevalence of childhood obesity has increased in parallel over the past few decades. …”
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“…A significant increase in BAX transcript levels after 12 hrs of exposure to BPA and BPF at the LOAEL dose (P=0.046, P= 0.033, n=6) as well as in BAD (P= 0.049, n=3) and Casp9 (P=0.049, n=4) levels after BPA exposure at the LOAEL dose was detected. Interestingly, at the 48 hr timepoint, a significant increase in BAD (P= 0.018, n= 9), BAX (P=0.002, n=10), and Casp9 (P=0.015, n=5) transcript levels was observed only following BPF treatment at the LOAEL dose. …”
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“…CONCLUSION: These important preliminary findings show VDR-target genes have correlated expression patterns within different tissues – one which stores vitamin D (adipose) and one which doesn't (intestinal). Interestingly, the VDR-target gene expression levels correlated with each other despite the genes being involved in different metabolic pathways in diverse tissues. …”
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“…A repeat 24-hour urine cortisol was again sent prior to surgery assuming initial test was lost. Interestingly, the initial 24-hour Urine free cortisol came back significantly elevated at 1,304 mcg (normal 2.3-37mcg) and urine free cortisol is . …”
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“…Adipocyte protein was western blotted for Total AKT and p-AKTSer473 and normalized to GAPDH. qPCR was performed to quantify insulin receptor (Insr), insulin receptor substrate 1 (Irs1), protein kinase B isoform 2 (Akt2), fork head box protein 1 (Foxo1) using the housekeeping gene Gapdh. 48-hour steroid treatments of E2 reduced pAKTSer473: AKT compared with that of controls in male vWAT. Interestingly, pAKTSer473: AKT of E(2)-treated male scWAT was unchanged compared with control levels. …”
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