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  1. 266081
    “…In line with the results of OCR and ECAR, we found Mφ during cPE challenge showed higher glycolytic ATP (glycoATP) production rates and lower mitochondrial ATP (mitoATP) production rates which is mainly from OXPHOS. Interestingly, MSCs showed enhanced glycolysis during challenge with cPE, but no significant changes in oxygen consumption rates (OCR). …”
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  2. 266082
    “…In the cecum of broilers with NE, the relative abundance of Barnesiella and Alistipes was higher and that of Lachnoclostridium and Shuttleworthia was lower. Interestingly, these trends were reversed by the addition of MCE to the diet. …”
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  3. 266083
  4. 266084
    “…Furthermore, we noted increases in the expression levels of EGFR, P-ERK, GLUT1, P-mTOR, and P-4EBP in the N-WASP(KOG12D) mice, suggesting that the deletion of N-WASP in the keratinocytes enhanced KRas signaling and glucose uptake, resulting in aggressive tumor formation. Interestingly, a thickening of the epidermal layer within the esophagus and tongue was only observed in the N-WASP(KOG12D) mice. …”
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  5. 266085
    “…BACKGROUND: Cross-sectional studies are useful for the estimation of prevalence of a particular event with concerns in specific populations, as in the case of diseases or other public health interests. Most of these studies have been carried out with binary binomial logistic regression model which estimates OR values that could be overestimated due to the adjustment of the model. …”
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  6. 266086
  7. 266087
  8. 266088
    “…We observed a decreased transcriptional activity of GR R569Q (EC(50) 4.55 nM [3.8;5.3]) compared to GR WT (EC(50) 0.19 nM [0.15; 0.24]), in response to dexamethasone. Interestingly, GR R569Q exerted a dominant negative effect on GR WT, with a decrease in transcriptional activity of 80% when stimulated with 1 nM dexamethasone (2-way ANOVA test, P<0.0001), which was blunted when stimulated with a 100-fold higher concentration of dexamethasone. …”
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  9. 266089
    “…Conclusion: In this explorative study, we found a higher number of CNAs in NFPAs with marked tumor progression compared to stable adenomas without the need for reintervention during the long-term follow-up. Interestingly, segmental losses of chromosome 10q23.21-q23.3, including the tumor suppressor gene PTEN, were overrepresented in patients with marked tumor progression. …”
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  10. 266090
    “…More studies evaluating germinative and somatic PRL-R variants are needed to clarify the PRL/PRL-R system role in the tumorigenesis and progression of prolactinomas and their interesting association with CAB resistance. Presentation: Friday, June 16, 2023…”
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  11. 266091
    “…Some of these cells, were lining the bone, presumably becoming osteoblasts, but interestingly did not increase their number despite SIK deletion and in contrast with the OsxCreER model. …”
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  12. 266092
    “…These findings suggest that the reduction in β-arrestin 2 recruitment does not cause the increased Ca(2+) response in the presence of SDCs, and that the effect of SDCs is probably downstream of Gα(q). Interestingly, the effects of SDCs mimic those of melanocortin receptor accessory protein 2 (MRAP2). …”
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  13. 266093
  14. 266094
    “…Dichtel is a Mass General Brigham (MGB) Innovation Fellow hosted by Third Rock Ventures. Financial interests were reviewed and are managed by MGH and MGB in accordance with their COI policies. …”
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  15. 266095
    “…Patient 7 has an elevated IGF-1 level. Interestingly, all patients have been noted to have elevated GDF-15 levels (ranging from 1662-2813pg/mL). …”
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  16. 266096
    “…Labs showed normal TSH 2.02uUI/ml, normal free T4 0.93 ng/dl, normal total T3 138 ng/dl. Interestingly, TSI antibody and TPO antibody were significantly elevated at 66.70 IU/L (0.0-0.55 IU/L) and 517 IU/ml (0-34 IU/ml), respectively. …”
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  17. 266097
    por Farooqi, Iqra N, Wang, Xiangbing
    Publicado 2023
    “…Thus, the role of varying 25(OH)D cutoffs is interesting and requires further investigation on a geographic level, as it may provide more insight into interethnic variations, correlation with seasonality and sunlight exposure, and healthcare access in regions where such studies have yet to be conducted. …”
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  18. 266098
    “…It is likely that changes in ghrelin also contribute to these adaptations to ER, however it was not measured in this study for technical reasons. Interestingly, the effect of short-term ER on specific food cravings is overwhelmed by the overall increase in appetite. …”
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  19. 266099
    “…MIB-1 proliferation index >3% was associated with higher CNV burden (p=0.022). Interestingly, copy number loss of chromosome 16 and 1q combined were exclusively identified in SA without GNAS mutations. …”
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  20. 266100
    “…Similarly, 13±4.3% of CD8 cells had plasticized into Tregs in treatment group supplemented with IL-2 while only 11.5±6.7% plasticized in treatment group without IL-2 supplementation. 14.3±5.8% plasticized to Tregs in treatment group in presence of CD3/CD28 microbeads compared to 12.4±6.3% in absolute control group. Interestingly, the plasticized Tregs from LADA patients were more robust than those of non-diabetic patients at a 1:2 ratio (Treg:Tresp). …”
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