Mostrando 266,141 - 266,160 Resultados de 266,632 Para Buscar '"interest"', tiempo de consulta: 1.36s Limitar resultados
  1. 266141
    “…However, nowadays, interventions delivered via mobile phones (mHealth) are an interesting alternative for health promotion, as they may more easily reach people 24/7. …”
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  2. 266142
  3. 266143
  4. 266144
    por Wong, Mun-Teng, Chen, Steve S.
    Publicado 2017
    “…PI4KIIIα inactivation by AL-9 or hCKα inactivation by CK37, a specific hCKα inhibitor, impaired the endoplasmic reticulum (ER) localization and colocalization of these three molecules. Interestingly, hCKα knockdown or inactivation inhibited PI4KIIIα-NS5A binding. …”
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  5. 266145
    “…Between 2007 and 2014, JLA partnerships of patients, carers and health professionals agreed on important treatment research questions (priorities) in a range of health conditions, such as Type 1 diabetes, eczema and stroke. We were interested in how much these JLA PSP priorities were similar to treatments undergoing evaluation and research over the same time span. …”
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  6. 266146
    por Mikami, Koichi, Sturdy, Steve
    Publicado 2017
    “…These include the costs of adjusting to abrupt changes in regulatory and commissioning processes, and the risk of being perceived as too close to commercial interests. To optimize use of scarce resources and ensure continuing active involvement, such risks and costs need to be better managed. …”
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  7. 266147
    por Madden, Mary, Morley, Richard
    Publicado 2016
    “…ABSTRACT: ᅟ BACKGROUND: Studies identifying a mismatch between the priorities of academics and clinicians and those of people with direct experience of a health condition pose a challenge to the assumption that professional researchers can represent the interests of patients and the public in setting priorities for health research. …”
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  8. 266148
    “…The lay members all reported that carrying out the observations had been an interesting and informative experience. Some challenges arose including the infrastructure not having been in place to support this specialist lay research role, differing paradigms of research governance held by the public and researchers in relation to consent procedures and difficulties in recruiting a diverse range of members of the public to carry out the role. …”
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  9. 266149
    “…The putative target, TP53INP1, showed an inverse expression relationship with miR-524-5p; direct TP53INP1 targeting was confirmed in luciferase assays. miR-524-5p-induced TP53INP1 downregulation enhanced cell proliferation, suppressed apoptosis, and upregulated the expression of pluripotency genes, all of which are critical early events of the reprogramming process. Interestingly, the TP53INP1 gene may have co-evolved late with the primate-specific miR-524-5p. miR-524-5p also promoted mesenchymal-to-epithelial transition (MET), a required initial event of reprogramming, by directly targeting the epithelial-to-mesenchymal transition (EMT)-related genes, ZEB2 and SMAD4. …”
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  10. 266150
    “…By analyzing IGF2-DMR0, we detected a consensus sequence for KLF4 with a z-score of 7.6. Interestingly, we found that KLF4 binds to hypomethylated (17%) IGF2-DMR0 enriched with H3K9me3 and H3K27me3 (LNCaP), but does not bind under hypermethylated (85%) and H3K4me3-enriched conditions (DU145). …”
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  11. 266151
    “…However, these SI entry points need to be placed in the context of the major drivers of change in the region, including market conditions, risks, and declining labor availability, and matching with the needs and interests of different types of farmers.…”
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  12. 266152
  13. 266153
    “…Consumers also had other general roles, for example in educating people about evidence or helping other consumers. There were some interesting examples of new ways of involving consumers. …”
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  14. 266154
    “…The study first compiled a long list of all possible outcome domains before asking interested parties, including patients, to vote which ones to include. …”
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  15. 266155
    “…Pedigrees originated in Italy, Brazil, Canada, England, Iran, and Japan. Interestingly, we identified 15 ALS5/SPG11/ KIAA1840 mutations in 12 families (two sequence variants were never reported before, p.Gln198* and p.Pro2212fs*5). …”
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  16. 266156
  17. 266157
    “…Training a ML algorithm revealed that PANSS, clinical and need of care features predicted our multiple endpoints best. Interestingly, EUFEST predictors included these three types of data as a main part of best performing predictors. …”
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  18. 266158
    “…Given the strong evidence of white matter (WM) alterations in schizophrenia as well as the current lack of etiological treatments, redox dysregulation is an interesting target. The current study aims at investigating the impact of NAC, a precursor of GSH, the main antioxidant in the brain, on WM integrity in patients in the early psychosis phase. …”
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  19. 266159
    “…Furthermore, PCB showed to be useful in [i] psychopathology in general, [ii] differentiating between recent-onset depression and psychotic symptoms, and [iii] between threshold and sub-threshold psychotic symptoms. Interestingly, long-term memory deficits contributed more in differentiating psychotic symptoms from other psychopathological entities (ROD vs CHR/ROP comparison) than along the spectrum of attenuated psychotic symptoms, resulting in full clinical picture of psychosis (CHR vs ROP). …”
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  20. 266160
    “…DISCUSSION: The results presented are partial, obtained with a provisional small sample size but they show some interesting trends. In general, there was a group tendency for a slightly worse performance after 7 years of the baseline assessment, but we could identify two groups of patients who differ from that general tendency: one with marked deterioration and one with improvement of executive performance over time. …”
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