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266141por Gomez Quiñonez, Stefanie, Walthouwer, Michel Jean Louis, Schulz, Daniela Nadine, de Vries, Hein“…However, nowadays, interventions delivered via mobile phones (mHealth) are an interesting alternative for health promotion, as they may more easily reach people 24/7. …”
Publicado 2016
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266142por McAlearney, Ann Scheck, Sieck, Cynthia J, Hefner, Jennifer L, Aldrich, Alison M, Walker, Daniel M, Rizer, Milisa K, Moffatt-Bruce, Susan D, Huerta, Timothy R“…During this time, patients may be more engaged with their care and especially interested in using tools to manage their health after discharge. …”
Publicado 2016
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266143por Spencer, CH, Rouster-Stevens, K, Gewanter, H, Syverson, G, Modica, R, Schmidt, K, Emery, H, Wallace, C, Grevich, S, Nanda, K, Zhao, YD, Shenoi, S, Tarvin, S, Hong, S, Lindsley, C, Weiss, JE, Passo, M, Ede, K, Brown, A, Ardalan, K, Bernal, W, Stoll, ML, Lang, B, Carrasco, R, Agaiar, C, Feller, L, Bukulmez, H, Vehe, R, Kim, H, Schmeling, H, Gerstbacher, D, Hoeltzel, M, Eberhard, B, Sundel, R, Kim, S, Huber, AM, Patwardhan, A“…The survey was completed online by the CARRA members interested in JDM in 2012. A second survey was similarly developed that provided more opportunity to describe their experiences with biologics in JDM in detail and was completed by CARRA members in Feb 2013. …”
Publicado 2017
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266144“…PI4KIIIα inactivation by AL-9 or hCKα inactivation by CK37, a specific hCKα inhibitor, impaired the endoplasmic reticulum (ER) localization and colocalization of these three molecules. Interestingly, hCKα knockdown or inactivation inhibited PI4KIIIα-NS5A binding. …”
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266145“…Between 2007 and 2014, JLA partnerships of patients, carers and health professionals agreed on important treatment research questions (priorities) in a range of health conditions, such as Type 1 diabetes, eczema and stroke. We were interested in how much these JLA PSP priorities were similar to treatments undergoing evaluation and research over the same time span. …”
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266146“…These include the costs of adjusting to abrupt changes in regulatory and commissioning processes, and the risk of being perceived as too close to commercial interests. To optimize use of scarce resources and ensure continuing active involvement, such risks and costs need to be better managed. …”
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266147“…ABSTRACT: ᅟ BACKGROUND: Studies identifying a mismatch between the priorities of academics and clinicians and those of people with direct experience of a health condition pose a challenge to the assumption that professional researchers can represent the interests of patients and the public in setting priorities for health research. …”
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266148por Garfield, Sara, Jheeta, Seetal, Jacklin, Ann, Bischler, Anna, Norton, Christine, Franklin, Bryony D.“…The lay members all reported that carrying out the observations had been an interesting and informative experience. Some challenges arose including the infrastructure not having been in place to support this specialist lay research role, differing paradigms of research governance held by the public and researchers in relation to consent procedures and difficulties in recruiting a diverse range of members of the public to carry out the role. …”
Publicado 2015
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266149por Nguyen, Phan Nguyen Nhi, Choo, Kong Bung, Huang, Chiu-Jung, Sugii, Shigeki, Cheong, Soon Keng, Kamarul, Tunku“…The putative target, TP53INP1, showed an inverse expression relationship with miR-524-5p; direct TP53INP1 targeting was confirmed in luciferase assays. miR-524-5p-induced TP53INP1 downregulation enhanced cell proliferation, suppressed apoptosis, and upregulated the expression of pluripotency genes, all of which are critical early events of the reprogramming process. Interestingly, the TP53INP1 gene may have co-evolved late with the primate-specific miR-524-5p. miR-524-5p also promoted mesenchymal-to-epithelial transition (MET), a required initial event of reprogramming, by directly targeting the epithelial-to-mesenchymal transition (EMT)-related genes, ZEB2 and SMAD4. …”
Publicado 2017
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266150por Schagdarsurengin, Undraga, Lammert, Angela, Schunk, Natalie, Sheridan, Diana, Gattenloehner, Stefan, Steger, Klaus, Wagenlehner, Florian, Dansranjavin, Temuujin“…By analyzing IGF2-DMR0, we detected a consensus sequence for KLF4 with a z-score of 7.6. Interestingly, we found that KLF4 binds to hypomethylated (17%) IGF2-DMR0 enriched with H3K9me3 and H3K27me3 (LNCaP), but does not bind under hypermethylated (85%) and H3K4me3-enriched conditions (DU145). …”
Publicado 2017
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266151por Kumar, Virender, Jat, Hanuman S., Sharma, Parbodh C., Balwinder-Singh, Gathala, Mahesh K., Malik, Ram K., Kamboj, Baldev R., Yadav, Arvind K., Ladha, Jagdish K., Raman, Anitha, Sharma, D.K., McDonald, Andrew“…However, these SI entry points need to be placed in the context of the major drivers of change in the region, including market conditions, risks, and declining labor availability, and matching with the needs and interests of different types of farmers.…”
Publicado 2018
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266152por Johnson, Adrienne, Severson, Eric, Gay, Laurie, Vergilio, Jo‐Anne, Elvin, Julia, Suh, James, Daniel, Sugganth, Covert, Mandy, Frampton, Garrett M., Hsu, Sigmund, Lesser, Glenn J., Stogner‐Underwood, Kimberly, Mott, Ryan T., Rush, Sarah Z., Stanke, Jennifer J., Dahiya, Sonika, Sun, James, Reddy, Prasanth, Chalmers, Zachary R., Erlich, Rachel, Chudnovsky, Yakov, Fabrizio, David, Schrock, Alexa B., Ali, Siraj, Miller, Vincent, Stephens, Philip J., Ross, Jeffrey, Crawford, John R., Ramkissoon, Shakti H.“…The genes most frequently mutated were TP53 (49%; 77/157), H3F3A (37.6%; 59/157), ATRX (24.2%; 38/157), NF1 (22.2%; 35/157), and PDGFRA (21.7%; 34/157). Interestingly, most H3F3A mutations (81.4%; 35/43) were the variant K28M. …”
Publicado 2017
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266153“…Consumers also had other general roles, for example in educating people about evidence or helping other consumers. There were some interesting examples of new ways of involving consumers. …”
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266154por Smith, Harriet, Horobin, Adele, Fackrell, Kathryn, Colley, Veronica, Thacker, Brian, Hall, Deborah A.“…The study first compiled a long list of all possible outcome domains before asking interested parties, including patients, to vote which ones to include. …”
Publicado 2018
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266155por Montecchiani, Celeste, Pedace, Lucia, Lo Giudice, Temistocle, Casella, Antonella, Mearini, Marzia, Gaudiello, Fabrizio, Pedroso, José L., Terracciano, Chiara, Caltagirone, Carlo, Massa, Roberto, St George-Hyslop, Peter H., Barsottini, Orlando G. P., Kawarai, Toshitaka, Orlacchio, Antonio“…Pedigrees originated in Italy, Brazil, Canada, England, Iran, and Japan. Interestingly, we identified 15 ALS5/SPG11/ KIAA1840 mutations in 12 families (two sequence variants were never reported before, p.Gln198* and p.Pro2212fs*5). …”
Publicado 2016
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266156por Zegers-Hochschild, Fernando, Adamson, G David, Dyer, Silke, Racowsky, Catherine, de Mouzon, Jacques, Sokol, Rebecca, Rienzi, Laura, Sunde, Arne, Schmidt, Lone, Cooke, Ian D, Simpson, Joe Leigh, van der Poel, Sheryl“…STUDY FUNDING/COMPETING INTERESTS: None. TRIAL REGISTRATION NUMBER: N/A.…”
Publicado 2017
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266157por De Nijs, Jessica, van Opstal, Daniel P J, Janssen, Ronald J, Cahn, Wiepke, Schnack, Hugo“…Training a ML algorithm revealed that PANSS, clinical and need of care features predicted our multiple endpoints best. Interestingly, EUFEST predictors included these three types of data as a main part of best performing predictors. …”
Publicado 2018
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266158por Klauser, Paul, Xin, Lijing, Fournier, Margot, Griffa, Alessandra, Cleusix, Martine, Jenni, Raoul, Cuenod, Michel, Gruetter, Rolf, Hagmann, Patric, Conus, Philippe, Baumann, Philipp, Do, Kim Q“…Given the strong evidence of white matter (WM) alterations in schizophrenia as well as the current lack of etiological treatments, redox dysregulation is an interesting target. The current study aims at investigating the impact of NAC, a precursor of GSH, the main antioxidant in the brain, on WM integrity in patients in the early psychosis phase. …”
Publicado 2018
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266159por Garzitto, Marco, Kambeitz-Ilankovic, Lana, Bonivento, Carolina, Piccin, Sara, Borgwardt, Stefan, Meisenzahl, Eva, Rosen, Marlene, Salokangas, Raimo, Upthegrove, Rachel, Wood, Stephen, Koutsouleris, Nikolaos, Brambilla, Paolo“…Furthermore, PCB showed to be useful in [i] psychopathology in general, [ii] differentiating between recent-onset depression and psychotic symptoms, and [iii] between threshold and sub-threshold psychotic symptoms. Interestingly, long-term memory deficits contributed more in differentiating psychotic symptoms from other psychopathological entities (ROD vs CHR/ROP comparison) than along the spectrum of attenuated psychotic symptoms, resulting in full clinical picture of psychosis (CHR vs ROP). …”
Publicado 2018
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266160por Fernandes, Thalita, Martins, Thais, Mustafé, Gustavo, Mendes, Diego, Pegoraro, Luiz Fernando, Dantas, Clarissa De Rosalmei“…DISCUSSION: The results presented are partial, obtained with a provisional small sample size but they show some interesting trends. In general, there was a group tendency for a slightly worse performance after 7 years of the baseline assessment, but we could identify two groups of patients who differ from that general tendency: one with marked deterioration and one with improvement of executive performance over time. …”
Publicado 2018
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