“…DISCUSSION: Although the healthy co-twins were all without clinical diagnoses, they had a subtle but significantly higher level of psychopathology and a lower level of function compared to HC. Interestingly, the healthy co-twin had an aberrant increased activity during evaluation of negative outcome compared to the HC but also compared to their diagnosed twin. …”
Enlace del recurso
Enlace del recurso

“…Process: To ensure religion-specific content was accurate and appropriate, a website prototype was built with content review and functionality testing by representatives from religious and cultural organizations and other interested health care organizations who completed a Web-based survey. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our findings demonstrate the large magnitude effect of iCBT for OCD; interestingly, iPRT was also moderately efficacious, albeit significantly less so than the iCBT intervention. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Future research endeavors should use a user-centered design to determine the role of mobile apps in the assessment and treatment of depression for this population, app features they would be interested in using, and strategies for long-term engagement. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The structural data for the complex cation, which contains a new unsaturated ‘S(4)’ ligand (two C=C double bonds), provide an inter­esting comparison with the known NiFe hydrogenase models containing a saturated ‘S(4)’-ligand analogue having the same number of carbon atoms in the ligand backbone, namely with the structures of [Ni(L)FeCp(CO)](+) (as the PF(6) (−) salt, CH(2)Cl(2) solvate) and [Ni(L)FeCp*(CO)](+) (as the PF(6) (−) salt), where (L)(2−) is [S—CH(2)—CH(2)—S—(CH(2))(3)—S—CH(2)—CH(2)—S](2−) and Cp(−) is cyclo­penta­dienyl. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There was also a need to be flexible and recognise other workload pressures. Interestingly, service providers and service users were keen to become more involved in data analysis – this is one of the most under-researched and reported areas within the coproduction literature. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Patients are recruited from NF-specific national and international foundations and NF clinics across the United States through study ads and a video of participants who have completed the program as part of the pilot study or ongoing trial. Interested participants are screened for eligibility via secure live videoconferencing (self-reported stress and difficulties coping, no change in antidepressant medication within the past 3 months, no psychotherapy within the past 3 months, no major upcoming surgeries within the next 12 months, English speaking, and able to complete questionnaires online and participate in live video interventions) and consent obtained before participation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mean (SD) eHEALS total score was 28.2 (6.2) for the whole sample, with statistically significant differences (P<.001) between the two groups, with the higher health literate group scoring significantly better (31.9 (5.9) vs 26.7 (5.6), respectively), with a standardized mean difference (Cohen d) of 0.9. Interestingly, we found a weak, yet significant, correlation between eHealth literacy and respondent characteristics for the higher health literate group only, as measured by positive Spearman correlation coefficients for age (0.11, P=.001), educational attainment (0.19, P=.002) and self-rated health (0.14, P=.024). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As data contain commercially confidential information, appropriate safeguards should be put in place to balance public health and commercial interests.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…STUDY FUNDING/COMPETING INTERESTS: The study was supported by IBSA. G.G. has received personal fees and non-financial support from MSD, Ferring, Merck-Serono, Finox, TEVA, IBSA, Glycotope, Abbott, Gedeon-Richter as well as personal fees from VitroLife, NMC Healthcare, ReprodWissen, BioSilu and ZIVA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…No significant change was observed in the placebo arm (13.2 to 13.1). Interestingly the papaya group showed a significant reduction of children with Tinea capitis (ringworms) (54.4 to 34%, p < 0.002) as compared to the albendazole arm that showed an increase in ringworm infestation though not statistically significant (39.7 to 64.7% p = 0.608). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: Four SMUG1 intron SNPs (rs3087404, rs2029167, rs2029166 and rs7296239) were genotyped by MA-PCR in 400 CSCCs, 400 CIN III and 1200 controls. qRT-PCR and Western blot were used to detect the SMUG1 mRNA and protein expression. Results: Interestingly, we found that the homozygous GG of rs3087404 had a significantly increased risk of CIN III [OR=1.78(1.27-2.51), P= 0.001] and CSCCs [OR=4.04(2.94-5.55), P=0.000]. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Comparison of uncommitted (NIH-3T3) and committed (3T3-L1) adipose precursor cells revealed that Zfp423 expression increased (p < 0.01) in parallel with the ability of the cells to differentiate into mature adipocytes owing to both decreased promoter DNA methylation (p < 0.001) and nucleosome occupancy (nucleosome [NUC] 1 p < 0.01; NUC2 p < 0.001) in the 3T3-L1 compared with NIH-3T3 cells. Interestingly, non-adipogenic epigenetic profiles can be reverted in NIH-3T3 cells as 5-azacytidine treatment increased Zfp423 mRNA levels (p < 0.01), reduced DNA methylation at a specific CpG site (p < 0.01), decreased nucleosome occupancy (NUC1, NUC2: p < 0.001) and induced adipocyte differentiation (p < 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Last, tested on a panel of primary osteosarcoma cell lines, MC3353 markedly inhibited cell growth with low single-digit micromolar IC(50) ranging from 1.1 to 2.4 μM. Interestingly, in Saos-2 osteosarcoma cells, MC3353 induced both expression of genes and mineralized the matrix as evidence of osteosarcoma to osteoblast differentiation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These findings have implications for future sexual health programs interested in improving the sexual health outcomes of young people. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Even though there is insufficient evidence to recommend treatment with LT4 to achieve low-normal TSH values in order to accomplish better lipid control, it may be beneficial in high risk patients. It would be interesting to evaluate lipid profile following an increase in LT4 dose, in order to better understand the effect of levothyroxine in these patients.…”
Enlace del recurso
Enlace del recurso

“…Trabecular bone parameters, bone density and breaking strength were unchanged. Interestingly, trabecular number (GC: 5.67mm(-1) v C: 5.51mm(-1), p<0.001), was higher and cortical bone fraction (GC:59.4% v C: 65.2%, p<0.001) was lower in dex 5 mice. …”
Enlace del recurso
Enlace del recurso

“…Our results showed that the SF3b subunit 1 (SF3B1) gene, which encodes a protein necessary for spliceosome assembly, was consistently overexpressed in all the ERCs evaluated in this study. Interestingly, SF3B1 expression was positively correlated and associated with clinical and molecular aggressiveness features (e.g. histopathological grade, presence of metastasis, expression of oncogenic splicing variants, etc.) in these ERCs. …”
Enlace del recurso
Enlace del recurso

“…WIDER IMPLICATIONS: The observed associations between endometriosis and autoimmune diseases suggest that clinicians need to be aware of the potential coexistence of endometriosis and autoimmune diseases when either is diagnosed. Scientists interested in research studies on endometriosis or autoimmune diseases should consider the likelihood of comorbidity when studying these two types of health conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Compared to uninfected controls, M. bovis BCG-infected mice exhibited increased CD4+ T cell and monocyte driven inflammation. Interestingly, M. bovis BCG-infected mice had a higher proportion of non-classical Ly6Clow monocytes, suggesting a pro-atherogenic contribution of these cells in our model. …”
Enlace del recurso
Enlace del recurso