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266241por Verelst, Faro, Beyens, Michiel, Vandenbroucke, Elke, Forceville, Kathleen, Twickler, Theodorus Bartholomeus“…In literature, we did not find similar cases. Interestingly, after adding T3, a good clinical and biochemical response was obtained suggesting a peripheral T4-T3 conversion block. …”
Publicado 2021
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266242“…Nevertheless, the responses to TSH (and fT4) and T3 were similar in offspring and controls. Interestingly, the maximal effect of TSH increment on bone resorption preceded that of fT4, suggesting that TSH may have an independent stimulatory effect on bone resorption. …”
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266243por Myint, Myat S, Htun, Kyaw W, Asfaw, Menilik, Chakravartty, Eesha, Mukherji, Rajat, Kazeem, Saka“…In the subset of DKA, interestingly, mean age (years) was 61.63 (SD±17.73) in CG and 39.67 in NCG (SD±13.39) (p=0.001). …”
Publicado 2021
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266244por Silva Moreira, Ana Rita, Lagasse, Alexandra, Haney, Anessa, Boehm, Ulrich, Kharas, Michael G, Lengner, Christopher J, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V, Odle, Angela Katherine“…Analysis of Gon-Msi-null ovaries revealed a 50% decrease in the number of follicles, with significant decreases in the average numbers of maturing follicles (p<0.0175) and corpora lutea (p<0.0215). Interestingly, the LH levels in these mice were also altered. …”
Publicado 2021
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266245por Miles, Tiffany K, Allensworth, Melody Lyn, Moreira, Ana Rita Silva, Odle, Angela Katherine, Haney, Anessa, Lagasse, Alexandra, MacNicol, Angus M, Childs, Gwen V“…CR20 offspring of both sexes had an early surge (PND8) that was 62% (P<0.0001) higher compared to offspring of Fed dams and was maintained at high levels until PND11. Interestingly, GH levels at PND1 were 354% (P<0.0001) higher in the CR20 progeny compared to controls. …”
Publicado 2021
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266246Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profilepor Jalali, Zahra, Bahrampour, Saeed, Khalili, Parvin, Khademalhosseini, Morteza, Esmaeili Nadimi, Ali“…This relationship persisted when fathers who used opioid by routes other than inhaling (oral) were excluded from logistic analysis (adjusted OR 1.73 (95% CI 1.12–2.68)). Interestingly, sex stratified analysis displayed a 201% increased odds ratio of overweight/obesity in sons of fathers who use opioid regularly, started after child birth (Adjusted OR 3.01 (95% CI 1.68–5.39), while no significant association was found in daughters (adjusted OR 0.74 (95% CI 0.35–1.54)). …”
Publicado 2021
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266247por Jaradat, Nidal, Hawash, Mohammed, Abualhasan, Murad N., Qadi, Mohammad, Ghanim, Mustafa, Massarwy, Eman, Ammar, Suma Abu, Zmero, Noor, Arar, Mohammad, Hussein, Fatima, Issa, Linda, Mousa, Ahmed, Zarour, Abdulraziq“…The Baqa al-Gharbiyye AC EO exerted more potent antioxidant activity than the Umm al-Fahm EO, with IC(50) values of 11.74 ± 0.18 and 35.48 ± 0.14 μg/mL, respectively, while the positive control Trolox had antioxidant IC(50) values of 2.45 ± 0.01 μg/mL. Interestingly, both EOs inhibited more potential activity against Methicillin-Resistant Staphylococcus aureus (MRSA) and Proteus vulgaris than Ciprofloxacin and Ampicillin antibiotics and also showed more potent antifungal activity against Candida albicans than Fluconazole. …”
Publicado 2021
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266248“…Conclusion: We report an interesting case of new-onset diabetes with hyperosmolarity associated with COVID-19 infection with rapid achievement of euglycemia upon resolution of viral infection. …”
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266249por Bustamante-Andrade, Jorge A., Meza-Herrera, César A., Rodríguez-Martínez, Rafael, Santos-Jimenez, Zurisaday, Ángel-García, Oscar, Gaytán-Alemán, Leticia R., Gutierrez-Guzman, Ulises N., Esquivel-Romo, Amaury, Véliz-Deras, Francisco G.“…Such reproductive strategy emerges as an interesting approach, not only to enhance the out-of-season reproductive outcomes, but also to boost one of the main rulers defining the global reproductive efficiency of a heard, namely, the embryo implantation efficiency.…”
Publicado 2021
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266250por Wu, Mingcan, Du, Ming, Wu, Guimei, Lu, Feimiao, Li, Jing, Lei, Anping, Zhu, Hui, Hu, Zhangli, Wang, Jiangxin“…When the Cl(−) concentration accumulates to a level of fivefold higher than that of the control, growth of E. gracilis is inhibited as the osmolality tolerance range is exceeded. Interestingly, the osmolality of the reused water can be reduced by replacing NH(4)Cl with urea as the source of nitrogen in the cultivation water. …”
Publicado 2021
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266251por Haderbache, Rafik, Warda, Walid, Hervouet, Eric, da Rocha, Mathieu Neto, Trad, Rim, Allain, Vincent, Nicod, Clementine, Thieblemeont, Catherine, Boissel, Nicolas, Varlet, Pauline, Agha, Ibrahim Yakoub, Bouquet, Lucie, Guiot, Melanie, Venet, Fabienne, Sujobert, Pierre, Roussel, Xavier, Rouzaire, Paul-Oliver, Caillot, Denis, Casasnovas, Olivier, Bories, Jean Christophe, Bachy, Emmanuel, Caillat-Zucman, Sophie, Deschamps, Marina, Ferrand, Christophe“…RESULTS: 28BBz and 28z ddPCR assays applied to 2 tumoral (acute myeloid leukemia (AML) or multiple myeloma (MM) xenograft humanized NSG mouse models allowed us to quantify the early expansion (up to day 30) of CAR T cells after injection. Interestingly, following initial expansion, when circulating CAR T cells were challenged with the tumor, we noted a second expansion phase. …”
Publicado 2021
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266252por Giroud, Maude, Tsokanos, Foivos-Filippos, Caratti, Giorgio, Kotschi, Stefan, Khani, Sajjad, Jouffe, Céline, Vogl, Elena S., Irmler, Martin, Glantschnig, Christina, Gil-Lozano, Manuel, Hass, Daniela, Khan, Asrar Ali, Garcia, Marcos Rios, Mattijssen, Frits, Maida, Adriano, Tews, Daniel, Fischer-Posovszky, Pamela, Feuchtinger, Annette, Virtanen, Kirsi A., Beckers, Johannes, Wabitsch, Martin, Uhlenhaut, Henriette, Blüher, Matthias, Tuckermann, Jan, Scheideler, Marcel, Bartelt, Alexander, Herzig, Stephan“…Furthermore, we identified gene clusters indirectly regulated by the GR–HAND2 pathway. Interestingly, silencing of HAND2 impaired adipocyte differentiation in hMADS and primary mouse adipocytes. …”
Publicado 2021
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266253por Yuxi, Zhang, Yanchao, Yuan, Zejun, Liu, Tao, Zhang, Feng, Li, Chunying, Liu, Shupeng, Gai“…The significant enrichment KEGG pathways of 849 DEGs highlighted plant hormone signal transduction, starch and sucrose metabolism, cell cycle, DNA replication, etc. Interestingly, the contents of endogenous GA(1), GA(3), GA(4), GA(7) and IAA significantly increased, ABA decreased after GA(3) and GA(4) treatments by LC–MS/MS. …”
Publicado 2021
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266254por Ahmed, Ziyan, Sherin, Rinsha P V, Fonseca, Tatiana De Lourdes, Hoang, Thanh Duc, Shakir, Mohamed K M“…We report a patient with TRD and primary hypothyroidism who responded to a combination of LT3, given in divided doses, and levothyroxine (LT4), rather than LT4 alone, even though the serum TSH levels were in the normal range with these treatments. Interestingly, the patient had a Thr92Ala5’ type 2 deiodinase polymorphism. …”
Publicado 2021
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266255por Rose, Susannah, Hurwitz, Heather McKee, Mercer, Mary Beth, Hizlan, Sabahat, Gali, Kari, Yu, Pei-Chun, Franke, Caroline, Martinez, Kathryn, Stanton, Matthew, Faiman, Matthew, Rasmussen, Peter, Boissy, Adrienne“…Most patients (393/423, 92.9%) agreed that their virtual visit clinician was interested in them as a person, and their virtual visit made it easy to get the care they needed (383/421, 90.9%). …”
Publicado 2021
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266256por Gowarty, Minda A, Longacre, Meghan R, Vilardaga, Roger, Kung, Nathan J, Gaughan-Maher, Ashley E, Brunette, Mary F“…RESULTS: Participants were 17 smokers who were not interested in quitting, with a mean age of 29 (SD 4) years; 41% (n=7) presented with psychotic disorders. …”
Publicado 2021
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266257por Bamodu, Oluwaseun Adebayo, Tzou, Kai-Yi, Lin, Chia-Da, Hu, Su-Wei, Wang, Yuan-Hung, Wu, Wen-Ling, Chen, Kuan-Chou, Wu, Chia-Chang“…More so, we observed a strong association between enhanced HSD17B2/SRD5A1 signaling and metastasis to distant lymph nodes (M1a) and bones (M1b), while upregulated HSD17B3/SHBG signaling correlated more with negative metastasis (M0) status. Interestingly, increased SHBG/SRD5A1 ratio was associated with metastasis to distant organs (M1c), while elevated SRD5A1/SHBG ratio was associated with positive biochemical recurrence (BCR) status, and shorter time to BCR. …”
Publicado 2021
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266258por Coras, Roxana, Kavanaugh, Arthur, Kluzniak, Angela, Holt, Dustina, Weilgosz, Amy, Aaron, Armando, Quehenberger, Oswald, Ritchlin, Christopher, Guma, Monica“…Oxylipin profiling did not associate with cDAPSA. Interestingly, several AA-derived oxylipins (5,15 di-HETE (5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic acid), 5-oxoETE (5-Oxo-eicosatetraenoic acid), PGE2 (prostaglandin E2), 11bPGE2 (11 beta prostaglandin D2), and LTB4 (leukotriene B4)) were significantly increased in PsA patients with enthesitis compared to those without. …”
Publicado 2021
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266259por Barker, Jenny C., Zbinden, Jacob, Mirhaidari, Gabriel, Blum, Kevin, Breuer, Christopher“…While these are known mediators for normal wound healing, specifically, for wound epithelialization and ECM deposition [3-5], the role of LYST in their intracellular protein trafficking and exocytosis has not been previously described. Interestingly, IGF-1 does rely on well-established exocytic pathways reliant on the synaptotagmin family of proteins [6]. …”
Publicado 2021
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266260“…The above two groups of genes were intersected to obtain 72 genes for functional annotation analysis. Interestingly, it indicated that 72 genes were mainly involved in immune processes and the Neddylation pathway. …”
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