“…Two radiologists independently measured ADC in fixed-sized regions of interests. Variables were MC-ADC (ADC in MC), MC-ADC% (0% = vertebral body, 100% = cerebrospinal fluid) and MC-ADC-ratio (MC-ADC divided by vertebral body ADC). …”
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“…The app was described as ‘very interesting’ to use by 44/62 (70.9%) of the participants, 20/44 males and 24/44 females. …”
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“…RESULTS: In MR analysis, 202 significant causative relationship features were identified. 7-alpha-hydroxy-3-oxo-4-cholestenoate (OR(IVW )=1.45; 95% CI: 1.06–1.97; P(IVW )=0.018), gamma-glutamylisoleucine (OR(IVW )=1.40; 95% CI: 1.16–1.69; P(IVW )=0.0004), 1-oleoylglycerophosphocholine (OR(IVW )=1.22; 95% CI: 1.1–1.35; P(IVW )=0.0001), gamma-glutamylleucine (OR(IVW )=4.74; 95% CI: 1.18–18.93; P(IVW )=0.027) were the most dangerous metabolites for lung cancer, ovarian cancer, breast cancer, and glioma, respectively; while pseudouridine (OR(IVW )=0.50; 95% CI: 0.30–0.83; P(IVW )=0.007), 2-methylbutyroylcarnitine (OR(IVW )=0.77; 95% CI: 0.68–0.86; P(IVW )=2.9×10(−6)), 2-methylbutyroylcarnitine (OR(IVW )=0.77; 95% CI: 0.70–0.85; P(IVW )=3.4×10(−7)), glycylvaline (OR(IVW )=0.13; 95% CI: 0.02–0.75; P(IVW )=0.021) were associated with lower risk of lung cancer, ovarian cancer, breast cancer, and glioma, respectively. Interestingly, 2-methylbutyroylcarnitine was also associated with decreased risk of lung cancer (OR(IVW )=0.59; 0.50–0.70; P(IVW) =1.98×10(−9)) expect ovarian cancer and breast cancer. …”
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“…LAP-overexpressing tumors in Hu-CD34(+)NSG mice recapitulated the patients’ chemo-immuno-resistant phenotype. Interestingly, the ROS scavenger mitoquinol chemo-immuno-sensitized immuno-xenografts, by disrupting the ROS/HIF-1α/LAP cascade. …”
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“…In vitro, NR4A1 was expressed in the nucleus of TICs, and NR4A1 as well as phospho-NR4A1 were decreased, following the apoptosis of TICs was emerged after cisplatin treatment. Interestingly, the localization of NR4A1 was translocated from the nucleus to the cytoplasm due to cisplatin. …”
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“…Functional experiments demonstrated that hSYISL and pSYISL regulate myogenesis through interactions with EZH2. Interestingly, we showed that SYISL functions to regulate muscle atrophy and sarcopenia through comparative analysis. …”
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“…About 27.8% of the parents were ready to vaccinate their children against COVID-19 as soon as possible, compared to 15.51% of parents who were not at all interested in vaccinating their children. Parents under 25 (34.48%) and over 41 (37.79%), non-Saudi (40.59%), holding postgraduate and higher degrees (39.5%), earning more than 10,000 SAR per month (34.96%), working as healthcare professionals (40.36%) and in government sectors (33.93%), self-employed (33.33%), with three to five children (35.26%) and male (31.33%) demonstrated significantly high willingness to vaccinate their children against the COVID-19 vaccine compared to their counterparts. …”
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“…The results indicated that compound 1 inhibited α-amylase activity in a manner similar to that of acarbose (which exhibit IC(50) values of 3.32 ± 0.30 µg/mL and 2.86 ± 0.10 µg/mL, respectively) in addition to a moderate inhibitory effect for compound 2 (IC(50) = 10.15 ± 0.53 µg/mL). Interestingly, compounds 1 and 2 significantly inhibited α-glucosidase and exhibited better inhibition than that of acarbose, with IC(50) values of 5.35 ± 1.66 µg/mL, 510.15 ± 1.46 µg/mL, and 736.93 ± 7.02 µg/mL, respectively. …”
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“…Insulin sensitivity was comparable between these genotypes. Interestingly, pancreatic islets isolated from FHL2-deficient mice secreted more insulin in GSIS assays than wild-type mouse islets even though insulin content and islet size was similar. …”
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“…Third, Singapore’s management policies have been made not only in a top-down, centralized style during the initial response stage, but also with a greater proportion of bottom-up approaches, particularly as the pandemic trudges on. More interestingly, the multi-faceted repercussions of COVID-19 have gradually opened the door to a greater variety of collaborative partnerships in sectors beyond healthcare services. …”
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“…BACKGROUND: Accessible nutrition resources tailored to patients with cancer, caregivers of cancer survivors, and people interested in cancer prevention are limited. Cook for Your Life is a bilingual (ie, English and Spanish) website providing science-based, nutrition information for people affected by cancer. …”
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“…In contrast, reduced TNF-α and IFN-γ expression and decreased human dNK cell activity were found following 2B4 activation during T. gondii infection. Interestingly, results showed that 2B4 binds to adaptor SHP-2 or Fyn, which then triggers different signaling pathways to regulate TNF-α and IFN-γ expression in dNK cells during T. gondii infection. …”
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“…Marked genetic diversity with 51 diverse STR types was noticed among the 106 isolates. Interestingly, two ongoing candidemia outbreaks were observed in two geographically separated hospitals both representing NICU isolates. …”
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“…Type 2 diabetes mellitus was the lead risk factor, with facial swelling being the predominant presentation. Interestingly, fungal smear was positive in 166 out of 238 patients. …”
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“…A large number of multidrug transporter genes (CDR1, MDR1, HGT2, HGT7, HGT13, HGT17, and NGT1) were differentially expressed between the two sets of strains. Interestingly, the overexpression of ERG11 (azole target gene), and CDR1 (drug transporter) genes was observed in resistant isolates as compared with susceptible strain. …”
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“…The crude mortality rate in resistant cases was 56.5% (13/23). Interestingly, all the fluconazole-resistant isolates were C. parapsilosis sensu stricto, while C. orthopsilosis and C. metapsilosis isolates were susceptible. …”
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“…We were particularly interested in testing the hypothesis that Moringa oleifera seed extracts do not have medicinal value in the mitigation of oxidative stress accompanying heat-stressed animals and, therefore, affecting growth performance and reproductive value. …”
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“…In contrast, patients whose B cell compartment primarily consisted of CD19(+)CD20(–) Bcells during acute COVID-19 disease or vaccination did not seroconvert. Interestingly, circulating Bcells in B cell depleted patients were significantly CD38(high) with co-expression of CD24 and CD27, indicating that B cell depletion may impact B cell activation patterns. …”
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“…The patient remained stable on this three monthly treatment till this day. Interestingly, the erosive changes on the x-rays of his hands and feet has not progressed since 2010, despite tolerance and efficacy challenges of his treatment. …”
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“…It is rare (1-25.000 to 1-50.000 live births) with a 5:1 male predilection; those affected present with a spectrum of abnormal facies, vertebral and limb anomalies including contractures. Interestingly a similar Bechet-like disease is also seen in patients who acquire Trisomy 8 mosaicism in cells affected by myeloid malignancies. …”
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