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  1. 266581
  2. 266582
    “…Results 10 males and 6 females between the ages of 24-81 were treated, 6 of which with HM. 12 patients were diagnosed by an RT-PCR-based technique while 4 were diagnosed by the highly sensitive clustered regularly interspaced short palindromic repeats (CRISPR)-based qualitative COVID-19 assay. Interestingly, these 4 patients have HM and had multiple false negative RT-PCR results prior to the CRISPR diagnosis. …”
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  3. 266583
    “…Being a candidate for intensive care treatments could improve survival while having progressive disease, older age and grade >3 neutropenia were considered negative factors. Interestingly, the use of steroids was associated to reduced survival if received within 15 days before COVID19 diagnosis, while it has protective effect when used as part of COVID19 therapy. …”
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  4. 266584
    “…However, the WHO estimates that nearly one‐third of all active tuberculosis cases go undiagnosed and unreported. We were interested in whether a single test, Xpert MTB/RIF or Xpert Ultra, could be useful as a screening test to close this diagnostic gap and improve tuberculosis case detection. …”
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  5. 266585
  6. 266586
    “…In myeloid neoplasms, patients with classical myeloproliferative neoplasm (MPN) had the highest negative result for antibodies with 4/7 (57.1%) followed by myelodysplastic syndrome (MDS) 2/7 (28.6%). Interestingly, all patients with chronic myeloid leukemia (CML) had a measurable immune response. …”
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  7. 266587
    “…In marked contrast, only 1 out of 14 CAR-T patients analyzed evidenced any relevant antibody-mediated SARS-CoV-2 neutralizing activity in their blood (Figure 1B). Interestingly, when we asked whether a globally insufficient antibody-mediated immunity was the underlying cause of the lack of a response to the COVID-19 vaccine in our CAR-T patients, we found that that was clearly not the case since anti-Flu, -TT, and -EBV responses were equivalent to the ones observed in HCs (Figure 2A). …”
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  8. 266588
    “…She had minimal muscle disease and no other extracutaneous manifestations. Interestingly, she developed lymphoma 3 years following the diagnosis of dermatomyositis.  …”
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  9. 266589
    “…CASE REPORT - DISCUSSION: This case is particularly interesting as it provides valuable first-hand insight into the manifestations and diagnostic challenges that still accompany the disease, 87 years after its first appearance in the literature. …”
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  10. 266590
    “…For pathway analysis, the most interesting finding of this study is that PPAR-ɤ is significantly up-regulated in early stage of disease when compared to late stage. …”
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  11. 266591
    “…Indentation results showed slightly higher equilibrium contact modulus in the cartilage surface layer of the nanowarming group (650.6 ± 134.7 kPa) than the convection group (567.7 ± 50.3 kPa) (No significance, N = 5 each group). Interestingly, aggregate modulus in nanowarming (326.7 ± 124.5 kPa, N = 14) and convection (334.6 ± 145.1 kPa, N = 7) groups were comparable and both significantly lower than the fresh (577.0 ± 229.6 kPa, N = 9) group via full thickness cartilage confined compression tests (p < 0.05), while no significant differences were found in permeability. …”
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  12. 266592
    “…Studies have proven that switching to a second TNF-alpha inhibitor is a strong therapeutic strategy. Interestingly, among the second line drugs, Secukinumab is found to be superior against adalimumab, leflunomide and ustekinumab. …”
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  13. 266593
    “…These include SLE, hepatocellular injury, adult onset Still’s disease (AOSD), and haematological malignancies. Interestingly, the patient also meets Yamaguchi criteria for diagnosis of AOSD due to having fever, rash, abnormal liver function tests, minor lymphadenopathy, and arthralgia. …”
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  14. 266594
    “…The evolution of SLE-like disease was predicted by the positive ANA, however, it is interesting to note that his initial anti-dsDNA titre and complement levels were normal. …”
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  15. 266595
    “…Pre-pandemic this was delivered face to face, and with social distancing guidelines in place we adapted virtually in response to patient need. We were interested to see if the children and young people were finding the intervention useful in their journey towards managing their pain. …”
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  16. 266596
    por Close, Rosie, Leahy, Alice, Nott, Kerstin
    Publicado 2022
    “…It has been reported that a high proportion of children with positive antiphospholipid antibodies don’t develop a thrombus. However, it is interesting that our patient was entirely asymptomatic from her pulmonary embolus which was an incidental finding on her CT angiogram. …”
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  17. 266597
    por Huber, Sebastian
    Publicado 2016
    “…Like in the 900 GeV data a pronounced dependency of the radii on the event multiplicity was discoverable. Another very interesting result that appeared was that the transverse dimensions of the pion emitting region do not significantly differ in the two observed energies (looking at equal multiplicity bins). …”
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  18. 266598
    “…On the other hand, top EC-associated miRNAs were implicated in lipid and atherosclerosis, Th1 and Th2 cell differentiation, Th17 cell differentiation, and glioma. Interestingly, infection of RMs with SIV revealed that the brain-enriched miR-128-3p was longitudinally and significantly downregulated in EVs, but not ECs. …”
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  19. 266599
    “…They are also involved in DNA binding and transactivation processes resembling the situation in AP-1 (Jun/Fos)-dependent DNA-binding in rheumatoid synovium. Most interestingly, these coiled-coil motifs are crucial for the assembly of viral proteins, and the upregulation of CENP-E might reflect the influence of infectious agents in RA synovium. …”
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  20. 266600
    por Joseph, Don R.
    Publicado 1911
    “…In future investigations we may try to answer these interesting questions. For the present, it is necessary to be content with the establishment of the bare facts as they are presented in the conclusions.…”
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