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2001“…BACKGROUND: The only established therapy for chronic viral delta hepatitis, the most severe form of viral hepatitis is treatment with pegylated-interferon α (Peg IFN α). OBJECTIVES: In this study, we aimed to determine the efficacy of pegylated-interferon α 2a (Peg-IFN α 2a) and 2b (Peg IFN α 2b) in the treatment of patients infected with chronic delta hepatitis virus. …”
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2002por Zhang, Shu-Min, Zhu, Li-Hua, Chen, Hou-Zao, Zhang, Ran, Zhang, Peng, Jiang, Ding-Sheng, Gao, Lu, Tian, Song, Wang, Lang, Zhang, Yan, Wang, Pi-Xiao, Zhang, Xiao-Fei, Zhang, Xiao-Dong, Liu, De-Pei, Li, HongliangEnlace del recurso
Publicado 2015
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2003“…BACKGROUND: There is growing concern that interferon-γ release assays (IGRAs) are being used off-label for the diagnosis of active tuberculosis (TB) disease in many high-burden settings, including India, where the background prevalence of latent TB infection is high. …”
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2004por Verweij, Marieke C., Wellish, Mary, Whitmer, Travis, Malouli, Daniel, Lapel, Martin, Jonjić, Stipan, Haas, Juergen G., DeFilippis, Victor R., Mahalingam, Ravi, Früh, Klaus“…Infection of rhesus macaques with simian varicella virus (SVV) recapitulates VZV pathogenesis in humans thus representing a suitable animal model for VZV infection. While the type I interferon (IFN) response has been shown to affect VZV replication, the virus employs counter mechanisms to prevent the induction of anti-viral IFN stimulated genes (ISG). …”
Publicado 2015
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2005“…OBJECTIVE: Partial sequence cloning of interferon receptor (IFNAR-1) of Columba livia. MATERIAL AND METHODS: In order to obtain a certain length (630 bp) of gene, a pair of primers was designed according to the conserved nucleotide sequence of Gallus (EU477527.1) and Taeniopygia guttata (XM_002189232.1) IFNAR-1 gene fragment that was published by GenBank. …”
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2006por Wilmes, Stephan, Beutel, Oliver, Li, Zhi, Francois-Newton, Véronique, Richter, Christian P., Janning, Dennis, Kroll, Cindy, Hanhart, Patrizia, Hötte, Katharina, You, Changjiang, Uzé, Gilles, Pellegrini, Sandra, Piehler, Jacob“…Type I interferons (IFNs) activate differential cellular responses through a shared cell surface receptor composed of the two subunits, IFNAR1 and IFNAR2. …”
Publicado 2015
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2007por Pang, Cai-Shuang, Shen, Yong-Chun, Tian, Pan-Wen, Zhu, Jing, Feng, Mei, Wan, Chun, Wen, Fu-Qiang“…Since a growing number of publications focus on the interferon-gamma release assay (IGRA), we meta-analyzed the available evidence on the overall diagnostic performance of IGRA applied to pleural fluid and peripheral blood. …”
Publicado 2015
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2008“…We report the three-dimensional structure of human interferon α-2A (IFN-α2A) bound to the Fab fragment of a therapeutic monoclonal antibody (sifalimumab; IgG1/κ). …”
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2009“…Ocular manifestations of BD mostly include bilateral panuveitis and retinal vasculitis, which are very challenging to treat. Interferon alfa-2a (IFN) has been recently introduced for treating refractory Behçet uveitis, mainly in Germany and Turkey. …”
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2010“…BACKGROUND: Type I interferons (IFN-Is) serve as mediators of antiviral innate immunity and also regulate adaptive immune responses. …”
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2011por Chen, Yaqin, Wu, Gang, Zhang, Hongmin, Xu, Hua, Li, Hong, Chen, Ling, Yang, Yixuan, Hu, Peng, Zhang, Dazhi, Ren, Hong, Hu, Huaidong“…This meta-analysis was performed to compare the effectiveness and risk of adverse events of interferon-based therapy with no treatment after liver transplantation. …”
Publicado 2015
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2012“…In this review, we provide our perspective on the importance of subdividing SS patients according to their interferon signature, and recommend choosing appropriate mouse models for interferon-positive and interferon-negative SS subtypes. …”
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2013“…Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens, in cancer and inflammatory diseases. …”
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2014“…Interferon (IFN) responses are critical for controlling herpes simplex virus 1 (HSV-1). …”
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2015por Su, Xiaodi, Yu, Yingpu, Zhong, Yi, Giannopoulou, Eugenia G., Hu, Xiaoyu, Liu, Hui, Cross, Justin R., Rätsch, Gunnar, Rice, Charles M., Ivashkiv, Lionel B.“…Interferon-γ (IFN-γ) primes macrophages for enhanced inflammatory activation by Toll-like receptors (TLRs) and microbial killing, but little is known about the regulation of cell metabolism or mRNA translation during priming. …”
Publicado 2015
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2016por Ruben, Jurjen M., Visser, Lindy L., Heinhuis, Kimberley M., O’Toole, Tom, Bontkes, Hetty J., Westers, Theresia M., Ossenkoppele, Gert J., de Gruijl, Tanja D., van de Loosdrecht, Arjan A.Enlace del recurso
Publicado 2015
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2017por Pei, Gang, Schnettger, Laura, Bronietzki, Marc, Repnik, Urska, Griffiths, Gareth, Gutierrez, Maximiliano Gabriel“…We find that in macrophages, Rab20 expression and endosomal association significantly increase after interferon-γ (IFN-γ) treatment. Moreover, IFN-γ and Rab20 expression induce a dramatic enlargement of endosomes. …”
Publicado 2015
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2018por Kakizaki, Aya, Fujimura, Taku, Furudate, Sadanori, Kambayashi, Yumi, Yamauchi, Takeshi, Yagita, Hideo, Aiba, Setsuya“…Together with regulatory T cells (Tregs), tumor-associated macrophages (TAMs) play roles in maintaining the tumor microenvironment. Since interferon beta (IFN-β) has been clinically used for the treatment of malignant melanoma, we investigated the immunomodulatory effect of IFN-β during melanoma growth to elucidate the effects of IFN-β on the tumor microenvironment by using the B16F10 melanoma model. …”
Publicado 2015
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2019“…OBJECTIVE: To determine compliance and improvement in sustained viral response (SVR) by following response guided therapy (RGT) plan of interferon and ribavirin, for genotype 3 in chronic hepatitis C. …”
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2020