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2041por Kmiec, Dorota, Iyer, Shilpa S., Stürzel, Christina M., Sauter, Daniel, Hahn, Beatrice H., Kirchhoff, Frank“…To determine whether this particular function enhances primary HIV-1 replication and interferon resistance, we introduced mutations into the vpu genes of HIV-1 group M and N strains to specifically disrupt their ability to antagonize tetherin, but not other Vpu functions, such as degradation of CD4, down-modulation of CD1d and NTB-A, and suppression of NF-κB activity. …”
Publicado 2016
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2042por Blount, Robert J., Tran, Minh-Chi, Everett, Charles K., Cattamanchi, Adithya, Metcalfe, John Z., Connor, Denise, Miller, Cecily R., Grinsdale, Jennifer, Higashi, Julie, Nahid, Payam“…BACKGROUND: Interferon-gamma release assays may be used as an alternative to the tuberculin skin test for detection of M. tuberculosis infection. …”
Publicado 2016
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2043“…Interferon gamma (IFN-γ) has antitumor and antiproliferative effects, and previous studies indicated IFN-γ +874T/A (rs2430561) polymorphism were related to the risk of many types of cancer. …”
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2044“…Here, we demonstrate that priming of microglia with interferon-γ (IFN γ) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. …”
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2045“…AIM OF THE STUDY: Many studies have shown that interferon-α (IFN-α) enhances the antiproliferative effect of gefitinib in some solid tumours. …”
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2046“…Furthermore, the CD4(+) T cell-secreted cytokine gamma interferon (IFN-γ) was found to be a key component of the protective antibody response. …”
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2047
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2048por Mahnke, Justus, Schumacher, Valéa, Ahrens, Stefanie, Käding, Nadja, Feldhoff, Lea Marie, Huber, Magdalena, Rupp, Jan, Raczkowski, Friederike, Mittrücker, Hans-Willi“…The transcription factor Interferon Regulatory Factor 4 (IRF4) is essential for T(H2) and T(H17) cell formation and controls peripheral CD8(+) T cell differentiation. …”
Publicado 2016
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2049por Arnold, Douglas L., Fisher, Elizabeth, Brinar, Vesna V., Cohen, Jeffrey A., Coles, Alasdair J., Giovannoni, Gavin, Hartung, Hans-Peter, Havrdova, Eva, Selmaj, Krzysztof W., Stojanovic, Miroslav, Weiner, Howard L., Lake, Stephen L., Margolin, David H., Thomas, David R., Panzara, Michael A., Compston, D. Alastair S.“…OBJECTIVE: To describe detailed MRI results from 2 head-to-head phase III trials, Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis Study I (CARE-MS I; NCT00530348) and Study II (CARE-MS II; NCT00548405), of alemtuzumab vs subcutaneous interferon β-1a (SC IFN-β-1a) in patients with active relapsing-remitting multiple sclerosis (RRMS). …”
Publicado 2016
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2050por Perl, AndrasEnlace del recurso
Publicado 2016
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2051“…Sarcoidosis is a diagnosis that should be considered in patients receiving interferon therapy, who present with anemia and multiorgan dysfunction regardless of the duration of their treatment. …”
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2052“…The treatment typically involves a combination of interferon-alpha (IFN-α) and ribavirin (RBV) therapy; however, the use of IFN-α is well documented to be associated with thyroid disease, the most common autoimmune disorder associated with IFN-α. …”
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2053por Rae, William, Gao, Yifang, Eren, Efrem, Döffinger, Rainer, Marshall, Ben, Williams, Anthony P.Enlace del recurso
Publicado 2016
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2054por Chmiest, Daniela, Sharma, Nanaocha, Zanin, Natacha, Viaris de Lesegno, Christine, Shafaq-Zadah, Massiullah, Sibut, Vonick, Dingli, Florent, Hupé, Philippe, Wilmes, Stephan, Piehler, Jacob, Loew, Damarys, Johannes, Ludger, Schreiber, Gideon, Lamaze, Christophe“…Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. …”
Publicado 2016
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2055por Mandrik, Olena, Knies, Saskia, Golubovska, Olha, Duda, Oleksandr, Dudar, Larisa, Fedorchenko, Sergiy, Zaliska, Olha, (Hans) Severens, J. L.“…Based on the pivotal trial showing no clinically relevant differences between pegylated interferon α-2b (Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin for treatment of chronic hepatitis C virus (HCV) genotype 1 infection in Ukraine, a cost-minimization analysis was performed using a 1 year time horizon and both a health care and patients’ perspective. …”
Publicado 2014
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2056por Perelman, Sofya S., Abrams, Michael E., Eitson, Jennifer L., Chen, Didi, Jimenez, Alyssa, Mettlen, Marcel, Schoggins, John W., Alto, Neal M.“…The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. …”
Publicado 2016
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2057“…Historically, observational clinical studies show that hypocholesterolemia is a common side effect of interferon (IFN) treatment. More recently, comprehensive systems-wide investigations of the macrophage IFN response reveal a direct molecular link between cholesterol metabolism and infection. …”
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2058por Arooj, Mahwish, Malik, Arif, Basit, Abdul, Husain Qazi, Mahmood, Asif, Muhammad, Sarwar Jamal, Mohammad, Mostafa Mahmoud, Maged, Choudhry, Hani, Natesan Pushparaj, Peter, Rasool, Mahmood“…Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. …”
Publicado 2016
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2059“…Moreover, 50 μg/ml DOX significantly decreased production of interferon-β and facilitated replication of transmissible gastroenteritis coronavirus in IPEC-J2 cells. …”
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2060por Suárez-Méndez, Roberto, García-García, Idrian, Fernández-Olivera, Norma, Valdés-Quintana, Magalys, Milanés-Virelles, María T, Carbonell, Dalia, Machado-Molina, Delfina, Valenzuela-Silva, Carmen M, López-Saura, Pedro A“…METHODS: To evaluate the action of interferon (IFN) gamma as immunoadjuvant to chemotherapy on pulmonary DR-TB patients, a pilot, open label clinical trial was carried out in the Cuban reference ward for the management of this disease. …”
Publicado 2004
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