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2061
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2062por Huang, Peng, Yao, Yinan, Yue, Ming, Tian, Ting, Chen, Hongbo, Chen, Mingzhu, Wang, Jie, Zhang, Yun, Yu, Rongbin“…Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. …”
Publicado 2017
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2063por Lange, Christoph, Mandalakas, Anna M., Kalsdorf, Barbara, Denkinger, Claudia M., Sester, Martina“…During the past decade, interferon-γ release assays (IGRAs) have increasingly replaced the tuberculin skin test as screening tools for the diagnosis of LTBI in countries with a low incidence of TB. …”
Publicado 2017
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2064por Suarez, Lorena P., Kemper, Gregory M., Duggan, Megan C., Stiff, Andrew, Noel, Tiffany C., Markowitz, Joseph, Luedke, Eric A., Yildiz, Vedat O., Yu, Lianbo, Jaime-Ramirez, Alena Cristina, Karpa, Volodymyr, Zhang, Xiaoli, Carson, William E.“…MLN2238 (ixazomib), an oral proteasome inhibitor, has improved pharmacotherapeutic parameters compared to bortezomib. Interferon-alpha (IFN-α), an immune boosting agent, is FDA-approved for treatment of melanoma. …”
Publicado 2016
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2065“…A tight balance of the mucosal immune system is essential to tolerate harmless antigens derived from food or commensals and to effectively defend against potentially dangerous pathogens. Interferons (IFN) provide a first line of host defense when cells detect an invading organism. …”
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2066por Sari, Novita Ita, Yang, Ying-Gui, Phi, Lan Thi Hanh, Kim, Hyungjoo, Baek, Moo Jun, Jeong, Dongjun, Kwon, Hyog Young“…Interferon-induced transmembrane protein 1 (IFITM1) has been shown to be implicated in multiple cancers, yet little is known about biological significance of IFITM1 in colorectal cancer. …”
Publicado 2016
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2067por Bakshi, Siddharth, Taylor, Jordan, Strickson, Sam, McCartney, Thomas, Cohen, Philip“…The double-stranded RNA mimetic poly(I:C) and lipopolysaccharide (LPS) activate Toll-like receptors 3 (TLR3) and TLR4, respectively, triggering the activation of TANK (TRAF family member-associated NF-κB activator)-binding kinase 1 (TBK1) complexes, the phosphorylation of interferon regulatory factor 3 (IRF3) and transcription of the interferon β (IFNβ) gene. …”
Publicado 2017
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2068“…Stimulator of interferon genes (STING) plays an important role in host defense, autoimmune disease, osteoclast differentiation and anti-tumor response. …”
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2069por Xia, Yuchen, Cheng, Xiaoming, Blossey, Christoph K., Wisskirchen, Karin, Esser, Knud, Protzer, Ulrike“…Interferon-α (IFN-α) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects. …”
Publicado 2017
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2070por Seo, Kwang Il, Yun, Byung Chul, Li, Weiquan James, Lee, Sang Uk, Han, Byung Hoon, Park, Eun Taek“…BACKGROUND/AIMS: Interferon-based treatment is not appropriate for a large number of patients with chronic hepatitis C for various medical and social reasons. …”
Publicado 2017
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2071por Liu, Qianqian, Li, Wenzhang, Chen, Yunfeng, Du, Xinmiao, Wang, Chengdi, Liang, Binmiao, Tang, Yin, Feng, Yulin, Tao, Chuanmin, He, Jian-Qing“…BACKGROUND: The diagnostic values of interferon-gamma release assays (IGRA) in tuberculosis (TB) vary a lot with different site of infections, with especially higher sensitivities in chronic forms of TB such as tuberculosis of the lymph node. …”
Publicado 2017
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2072
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2073por Khiar, Samira, Lucas-Hourani, Marianne, Nisole, Sébastien, Smith, Nikaïa, Helynck, Olivier, Bourgine, Maryline, Ruffié, Claude, Herbeuval, Jean-Philippe, Munier-Lehmann, Hélène, Tangy, Frédéric, Vidalain, Pierre-Olivier“…The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. …”
Publicado 2017
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2074“…However, in human liver, interferon (IFN)‐stimulated gene expression can mask direct transcriptional responses to infection. …”
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2075“…BACKGROUND: Interferon induced transmembrane protein 3 (IFITM3) plays an important role in the tumorigenesis and progression of multiple cancers. …”
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2076
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2077por Peters, Fleur S., Peeters, Annemiek M. A., Hofland, Leo J., Betjes, Michiel G. H., Boer, Karin, Baan, Carla C.“…Here, we determined the effect of tacrolimus and MPA on DNA methylation of the gene promoter region of interferon gamma (IFNγ), a pro-inflammatory cytokine. …”
Publicado 2017
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2078“…MxA protein is expressed in response to type I and type III Interferon and constitute an important antiviral factor with broad antiviral activity to diverse RNA viruses. …”
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2079por van de Garde, Martijn D. B., Pas, Suzan D., van Oord, Gertine W., Gama, Lucio, Choi, Youkyung, de Man, Robert A., Boonstra, Andre, Vanwolleghem, Thomas“…We studied the antiviral potency of pegylated interferon-α (pegIFNα) against HEV infections in humanized mice and modelled intrahepatic interferon stimulated gene (ISG) responses. …”
Publicado 2017
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2080“…Microarray and methylome analyses revealed that DME upregulated a number of genes including cell cycle components, heat shock proteins, and notably, various interferon-stimulated genes. Moreover, DME-mediated DNA demethylation activated endogenous repeat elements, which are likely to form dsRNAs as viral mimics and eventually trigger interferon cascades to establish the antiviral state. …”
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