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201“…A specific protein, interferon-tau (IFNT), stimulates interferon-stimulated genes (ISGs), and their expression increases during gestation within 21 days after insemination. …”
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203por Galbraith, Matthew D., Kinning, Kohl T., Sullivan, Kelly D., Araya, Paula, Smith, Keith P., Granrath, Ross E., Shaw, Jessica R., Baxter, Ryan, Jordan, Kimberly R., Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A., Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Guo, Kejun, Wilson, Cara C., Santiago, Mario L., Monte, Andrew A., Bennett, Tellen D., Hansen, Kirk C., Hsieh, Elena W. Y., D’Alessandro, Angelo, Espinosa, Joaquin M.“…The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. …”
Publicado 2022
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204“…The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interferon-gamma, has been identified as the main link in the immune response in tuberculosis. …”
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205por Shanmuganathan, Gaithrri, Orujyan, Davit, Narinyan, William, Poladian, Nicole, Dhama, Sanya, Parthasarathy, Arpitha, Ha, Alexandra, Tran, Daniel, Velpuri, Prathosh, Nguyen, Kevin H., Venketaraman, Vishwanath“…Following M. tb infection, cytokines such as interferons (IFNs) are released as part of the host immune response. …”
Publicado 2022
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206“…Interferon epsilon (IFN-ε) is a type I IFN. Some biological properties has been identified in many species, such as antiproliferative, anti-tumor, and antiviral effects, of IFN-ε, which are much weaker than those of IFN-α, have also been revealed. …”
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207por Blanco, Jorge C. G., Contursi, Cristina, Salkowski, Cindy A., DeWitt, David L., Ozato, Keiko, Vogel, Stefanie N.“…In this study, we demonstrate that interferon (IFN)-γ alone or in synergy with lipopolysaccharide (LPS) or interleukin 1α induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E(2) (PGE(2)) release. …”
Publicado 2000
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208“…Interferon (IFN)-τ secreted only by ruminant endometrium, helps in maternal recognition of pregnancy and exhibit antiviral and antiproliferative activity. …”
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209por Patel, Ami A., Lee-Lewis, Hanni, Hughes-Hanks, Jennifer, Lewis, Craig A., Anderson, Deborah M.“…Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells. …”
Publicado 2012
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210“…Our aim was to identify conformational epitopes, recognized by monoclonal antibodies (mAbs) made against human (h) interferon (IFN)-γ. Based on the mAbs' (n = 12) ability to simultaneously bind hIFN-γ in ELISA, 2 epitope clusters with 5 mAbs in each were defined; 2 mAbs recognized unique epitopes. …”
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211por Li, Yong, Zhu, Chuanlong, Wang, Faxi, Zhu, Tiantian, Li, Jun, Liu, Shufeng, Xiao, Fei“…Interferon-α (IFN-α) has limited response rate in the treatment of chronic hepatitis B (CHB). …”
Publicado 2016
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212por Chen, Changguo, Chen, Lei, Chen, Changwei, Chen, Qiuyuan, Zhao, Qiangyuan, Dong, YouyouEnlace del recurso
Publicado 2017
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213por Sung, Pil Soo, Lee, Eun Byul, Park, Dong Jun, Lozada, Angelo, Jang, Jeong Won, Bae, Si Hyun, Choi, Jong Young, Yoon, Seung Kew“…BACKGROUND/AIMS: Hepatitis C virus (HCV) replicates in the peripheral blood mononuclear cells (PBMCs), leading to the production of type I interferons (IFNs). It is well known that the gene expression profile of PBMC is similar to that of the liver. …”
Publicado 2018
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214“…The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). …”
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215“…Recombinant camel IFN-α1 induced the mRNA expression of interferon-stimulated genes (ISGs) in camel kidney cells. …”
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216por Nowacki, W., Cederblad, Britta, Renard, Christine, La Bonnardière, C., Charley, B.“…Porcine blood mononuclear cells (PBMC) were shown to secrete interferon α (IFN-α) after induction by a coronavirus, the transmissible gastroenteritis virus (TGEV). …”
Publicado 1993
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217por Busse, D. C., Habgood-Coote, D., Clare, S., Brandt, C., Bassano, I., Kaforou, M., Herberg, J., Levin, M., Eléouët, J.-F., Kellam, P., Tregoning, J. S.“…Cellular intrinsic immunity, mediated by the expression of an array of interferon-stimulated antiviral genes, is a vital part of host defense. …”
Publicado 2020
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218“…The data suggest that TRAIL-induced IFNB1 expression in MCF-7 cells is dependent on a non-apoptotic role of caspase-8 and leads to autocrine interferon-β signaling.…”
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219“…Under normoxic conditions, HMGB1 activates interferon regulatory factor (IRF)5 and nuclear factor-κB in monocytes, leading to expression of type I interferon (IFN) and inflammatory cytokines including tumor necrosis factor α, and interleukin 1β, respectively. …”
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220por Shi, Ying, Du, Lingyao, Lv, Duoduo, Li, Hong, Shang, Jin, Lu, Jiajie, Zhou, Lingyun, Bai, Lang, Tang, Hong“…The negative regulators in the interferon (IFN) signaling pathway inhibit intrahepatic immune response, resulting in suboptimal therapeutic response to IFNα treatment in chronic hepatitis B (CHB) patients. …”
Publicado 2019
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