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2261por Van Leuven, James T., Gonzalez, Andres J., Ijezie, Emmanuel C., Wixom, Alexander Q., Clary, John L., Naranjo, Maricris N., Ridenhour, Benjamin J., Miller, Craig R., Miura, Tanya A.“…Findings common to both virus pairs included the upregulated expression of mucin-associated genes and dampening of inflammation-related genes in mice that were inoculated with RV before lethal virus infection. However, type I interferon (IFN) signaling was required for RV-mediated protection against PR8 but not PVM. …”
Publicado 2021
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2262“…Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. …”
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2263por Steindor, Mathis, Stehling, Florian, Olivier, Margarete, Kehrmann, Jan, Diricks, Margo, Maurer, Florian P., Horn, Peter A., Straßburg, Svenja, Welsner, Matthias, Sutharsan, Sivagurunathan, Lindemann, Monika“…In this study, we aimed to establish an MABC-specific interferon-γ release assay to detect host immune responses to MABC and improve diagnostics of MABC infection by the detection of antigen-specific T cells. …”
Publicado 2021
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2264por Collins, Alexis, Lendrem, Dennis, Wason, James, Tarn, Jessica, Howard-Tripp, Nadia, Bodewes, Iris, Versnel, Marjan A., Gottenberg, Jacques-Eric, Seror, Raphaele, Mariette, Xavier, Ng, Wan-Fai“…To re-analyse the clinical outcomes and interferon (IFN) activity data from the JOQUER trial, a phase III trial investigating hydroxychloroquine (HCQ) in patients with primary Sjögren’s syndrome (pSS), after stratifying patients into putative pathobiological subgroups utilizing the Newcastle Sjögren’s Stratification Tool (NSST) based on patient-reported symptoms of dryness, pain, fatigue, anxiety and depression. 107 patients were assigned to one of four subgroups using NSST at baseline—the high symptom burden (HSB), pain dominant with fatigue (PDF), dryness dominant with fatigue (DDF) and low symptom burden (LSB). …”
Publicado 2021
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2266por Asako, Mizuki, Matsunaga, Hitomi, Nakahara, Wataru, Ikeda, Mako, Mima, Fuka, Minami, Ryota, Sekiguchi, Masahiro, Oka, Kazumasa, Wada, Naoki, Suzuki, Katsuhiro, Yoshizawa, Kazutaka, Sakagami, Takuro, Ueda, Shuji“…She was treated unsuccessfully with various antibiotics, and it was very challenging to reach a diagnosis. (18)F-Fluorodeoxyglucose ((18)F-FDG) uptake in bones was evaluated using positron emission tomography-computed tomography (PET-CT), and disseminated mycobacterial infection was suspected. The interferon-gamma (IFN-γ) release assays QuantiFERON (QFT) and T-SPOT were used to diagnose tuberculosis infection. …”
Publicado 2021
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2267por Imgenberg-Kreuz, Juliana, Sandling, Johanna K., Norheim, Katrine Brække, Johnsen, Svein Joar Auglænd, Omdal, Roald, Syvänen, Ann-Christine, Svenungsson, Elisabet, Rönnblom, Lars, Eloranta, Maija-Leena, Nordmark, Gunnel“…Primary Sjögren’s syndrome (pSS) is an autoimmune inflammatory disease with profound clinical heterogeneity, where excessive activation of the type I interferon (IFN) system is considered one of the key mechanisms in disease pathogenesis. …”
Publicado 2021
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2268por Leviyang, Sivan“…The type I interferon (IFN) signaling pathway involves binding of the transcription factor ISGF3 to IFN-stimulated response elements, ISREs. …”
Publicado 2021
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2269“…In this report, by using Zika virus (ZIKV) as a model, we first demonstrated that ZIKV antagonized interferon signalling in an infectious dose-dependent manner; in other words, the virus antagonized interferon signalling at a high multiple of infection (MOI) and was sensitive to interferon signalling at a low MOI. …”
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2270por Ren, Yan-Long, Li, Tao-Tao, Cui, Wei, Zhao, Li-Min, Gao, Na, Liao, Hua, Zhang, Jiang-Hui, Zhu, Jun-Ming, Qiao, Zhi-Yu, Guo, Shi-Chao, Pan, Li-Li“…Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). …”
Publicado 2021
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2271por Tarigan, Ronald, Katta, Tetsufumi, Takemae, Hitoshi, Shimoda, Hiroshi, Maeda, Ken, Iida, Atsuo, Hondo, Eiichi“…The expression levels of pattern recognition receptors (PRRs) (TLR3, RIG-I, and MDA5) and interferons (IFNB1 and IFNL1) were higher and PRV replication was lower in cell lines derived from M. fuliginosus, R. ferrumequinum, and R. leschenaultii. …”
Publicado 2021
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2272“…Interferon (IFN)-β is a popular therapy for multiple sclerosis (MS). …”
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2273por Shaldzhyan, Aram, Zabrodskaya, Yana, Yolshin, Nikita, Kudling, Tatiana, Lozhkov, Alexey, Plotnikova, Marina, Ramsay, Edward, Taraskin, Aleksandr, Nekrasov, Peter, Grudinin, Mikhail, Vasin, Andrey“…Type III interferons exhibit antiviral activity against influenza viruses, coronaviruses, rotaviruses, and others. …”
Publicado 2021
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2274por Chen, Yan-Jie, Luo, Shu-Neng, Dong, Ling, Liu, Tao-Tao, Shen, Xi-Zhong, Zhang, Ning-Ping, Liang, Li“…BACKGROUND: Since interferon regulatory factor (IRF) family functions in immune response to viral infection, its role in colorectal cancer (CRC) has not been inspected before. …”
Publicado 2021
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2275por Lorenzi, Luisa, Lonardi, Silvia, Vairo, Donatella, Bernardelli, Andrea, Tomaselli, Michela, Bugatti, Mattia, Licini, Sara, Arisi, Mariachiara, Cerroni, Lorenzo, Tucci, Alessandra, Vermi, William, Giliani, Silvia Clara, Facchetti, Fabio“…In BPDCN, we also assessed the immunomodulatory activity of malignant pDCs through the expression of several type I interferon (IFN-I) signaling effectors and downstream targets, PD-L1/CD274, and determined the extent of tumor infiltration by CD8-expressing T cells. …”
Publicado 2021
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2276por Cheroni, Cristina, Manganaro, Lara, Donnici, Lorena, Bevilacqua, Valeria, Bonnal, Raoul J. P., Rossi, Riccardo L., De Francesco, Raffaele“…Interferons (IFNs) are key cytokines involved in alerting the immune system to viral infection. …”
Publicado 2021
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2277por Zhang, Peipei, Schlecht, Anja, Wolf, Julian, Boneva, Stefaniya, Laich, Yannik, Koch, Jana, Ludwig, Franziska, Boeck, Myriam, Thien, Adrian, Härdtner, Carmen, Kierdorf, Katrin, Agostini, Hansjürgen, Schlunck, Günther, Prinz, Marco, Hilgendorf, Ingo, Wieghofer, Peter, Lange, Clemens“…METHODS: In this study, we examined interferon-regulatory factor 8 (Irf8)–deficient mice to determine the transcriptional profile, morphology, and temporospatial distribution of microglia lacking Irf8 and to explore the effects on retinal development, tissue homeostasis, and formation of choroidal neovascularisation (CNV). …”
Publicado 2021
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2278por Ll Wilkinson, Meredyth G., Deakin, Claire T., Papadopoulou, Charalampia, Eleftheriou, Despina, Wedderburn, Lucy R.“…An upregulated type I interferon signature is strongly associated with disease and could be a prime target for developing more specific therapeutics. …”
Publicado 2021
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2279por Shibuya, Meito, Tamiya, Shigeyuki, Kawai, Atsushi, Hirai, Toshiro, Cragg, Mark S., Yoshioka, YasuoEnlace del recurso
Publicado 2021
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2280por Gusyatiner, Olga, Bady, Pierre, Pham, Minh D T, Lei, Yvonne, Park, Jungyeon, Daniel, Roy T, Delorenzi, Mauro, Hegi, Monika E“…RESULTS: Cancer-relevant pathways significantly modulated by JQ1 comprised interferon alpha (IFN-α) response genes and response signatures to histone deacetylase inhibitors (HDACi). …”
Publicado 2021
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