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  1. 2261
    “…Findings common to both virus pairs included the upregulated expression of mucin-associated genes and dampening of inflammation-related genes in mice that were inoculated with RV before lethal virus infection. However, type I interferon (IFN) signaling was required for RV-mediated protection against PR8 but not PVM. …”
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    Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
  2. 2262
    “…Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. …”
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    Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens
  3. 2263
    “…In this study, we aimed to establish an MABC-specific interferon-γ release assay to detect host immune responses to MABC and improve diagnostics of MABC infection by the detection of antigen-specific T cells. …”
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    Species-Specific Interferon-Gamma Release Assay for the Diagnosis of Mycobacterium abscessus Complex Infection
  4. 2264
    “…To re-analyse the clinical outcomes and interferon (IFN) activity data from the JOQUER trial, a phase III trial investigating hydroxychloroquine (HCQ) in patients with primary Sjögren’s syndrome (pSS), after stratifying patients into putative pathobiological subgroups utilizing the Newcastle Sjögren’s Stratification Tool (NSST) based on patient-reported symptoms of dryness, pain, fatigue, anxiety and depression. 107 patients were assigned to one of four subgroups using NSST at baseline—the high symptom burden (HSB), pain dominant with fatigue (PDF), dryness dominant with fatigue (DDF) and low symptom burden (LSB). …”
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    Revisiting the JOQUER trial: stratification of primary Sjögren’s syndrome and the clinical and interferon response to hydroxychloroquine
  5. 2265
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    Local tissue development of type 1 innate lymphoid cells: guided by interferon-gamma
  6. 2266
    “…She was treated unsuccessfully with various antibiotics, and it was very challenging to reach a diagnosis. (18)F-Fluorodeoxyglucose ((18)F-FDG) uptake in bones was evaluated using positron emission tomography-computed tomography (PET-CT), and disseminated mycobacterial infection was suspected. The interferon-gamma (IFN-γ) release assays QuantiFERON (QFT) and T-SPOT were used to diagnose tuberculosis infection. …”
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    Mycobacterial lymphadenitis without granuloma formation in a patient with anti-interferon-gamma antibodies
  7. 2267
    “…Primary Sjögren’s syndrome (pSS) is an autoimmune inflammatory disease with profound clinical heterogeneity, where excessive activation of the type I interferon (IFN) system is considered one of the key mechanisms in disease pathogenesis. …”
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    DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren’s Syndrome
  8. 2268
    por Leviyang, Sivan
    Publicado 2021
    “…The type I interferon (IFN) signaling pathway involves binding of the transcription factor ISGF3 to IFN-stimulated response elements, ISREs. …”
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    Interferon stimulated binding of ISRE is cell type specific and is predicted by homeostatic chromatin state
  9. 2269
    “…In this report, by using Zika virus (ZIKV) as a model, we first demonstrated that ZIKV antagonized interferon signalling in an infectious dose-dependent manner; in other words, the virus antagonized interferon signalling at a high multiple of infection (MOI) and was sensitive to interferon signalling at a low MOI. …”
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    NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling
  10. 2270
    “…Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). …”
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    CD8(+) T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
  11. 2271
    “…The expression levels of pattern recognition receptors (PRRs) (TLR3, RIG-I, and MDA5) and interferons (IFNB1 and IFNL1) were higher and PRV replication was lower in cell lines derived from M. fuliginosus, R. ferrumequinum, and R. leschenaultii. …”
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    Distinct interferon response in bat and other mammalian cell lines infected with Pteropine orthoreovirus
  12. 2272
    “…Interferon (IFN)-β is a popular therapy for multiple sclerosis (MS). …”
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    Interferon-β Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease
  13. 2273
    “…Type III interferons exhibit antiviral activity against influenza viruses, coronaviruses, rotaviruses, and others. …”
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    Clean and folded: Production of active, high quality recombinant human interferon-λ1
  14. 2274
    “…BACKGROUND: Since interferon regulatory factor (IRF) family functions in immune response to viral infection, its role in colorectal cancer (CRC) has not been inspected before. …”
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    Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer
  15. 2275
    “…In BPDCN, we also assessed the immunomodulatory activity of malignant pDCs through the expression of several type I interferon (IFN-I) signaling effectors and downstream targets, PD-L1/CD274, and determined the extent of tumor infiltration by CD8-expressing T cells. …”
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    E-Cadherin Expression and Blunted Interferon Response in Blastic Plasmacytoid Dendritic Cell Neoplasm
  16. 2276
    “…Interferons (IFNs) are key cytokines involved in alerting the immune system to viral infection. …”
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    Novel interferon-sensitive genes unveiled by correlation-driven gene selection and systems biology
  17. 2277
    “…METHODS: In this study, we examined interferon-regulatory factor 8 (Irf8)–deficient mice to determine the transcriptional profile, morphology, and temporospatial distribution of microglia lacking Irf8 and to explore the effects on retinal development, tissue homeostasis, and formation of choroidal neovascularisation (CNV). …”
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    The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation
  18. 2278
    “…An upregulated type I interferon signature is strongly associated with disease and could be a prime target for developing more specific therapeutics. …”
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    JAK inhibitors: a potential treatment for JDM in the context of the role of interferon-driven pathology
  19. 2279
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    Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza
  20. 2280
    “…RESULTS: Cancer-relevant pathways significantly modulated by JQ1 comprised interferon alpha (IFN-α) response genes and response signatures to histone deacetylase inhibitors (HDACi). …”
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    BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma
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