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2301por Zhang, Ke, Xu, Pan-Ling, Li, Yu-Jie, Dong, Shu, Gao, Hui-Feng, Chen, Lian-Yu, Chen, Hao, Chen, Zhen“…BACKGROUND: Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. …”
Publicado 2022
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2302por Lu, Ling-Ying, Feng, Po-Hao, Yu, Ming-Sun, Chen, Min-Chi, Lin, Alex Jia-Hong, Chen, Justin L., Yu, Lennex Hsueh-Lin“…Recent studies have identified an association between perturbed type I interferon (IFN) responses and the severity of coronavirus disease 2019 (COVID-19). …”
Publicado 2022
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2303por Das, Mithun, Smith, Monique L., Furihata, Tomomi, Sarker, Subir, O’Shea, Ross, Helbig, Karla J.“…Our data suggest that astrocytes can resist ZIKV both in an interferon type I- and III-independent manner and suggest that an early and more diverse antiviral response may be more effective in controlling Zika infection. …”
Publicado 2022
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2304“…BACKGROUND: Interferon α-2b is a vital biotherapeutic produced through the recombinant DNA technology in E. coli. …”
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2305“…Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. …”
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2306por Ambruso, Daniel R., Briones, Natalie J., Baroffio, Angelina F., Murphy, John R., Tran, Alexander D., Gowan, Katherine, Sanford, Bridget, Ellison, Michael, Jones, Kenneth L.“…The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). …”
Publicado 2022
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2307por Madany, Emaan, Lee, June, Halprin, Chelsea, Seo, Jina, Baca, Nicole, Majlessipour, Fataneh, Hendrickson, Jeanne E., Pepkowitz, Samuel H., Hayes, Chelsea, Klapper, Ellen, Gibb, David R.“…Given that proinflammatory type 1 interferons (IFNα/β) and interferon stimulated genes (ISGs) promote alloimmunization in mice, we hypothesized that IFNα/β may contribute to the increased frequency of alloimmunization in patients with SCD. …”
Publicado 2021
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2308por Sadanari, Hidetaka, Takemoto, Masaya, Ishida, Tomoki, Otagiri, Hikaru, Daikoku, Tohru, Murayama, Tsugiya, Kusano, Shuichi“…Human phospholipid scramblase 1 (PLSCR1) is strongly expressed in response to interferon (IFN) treatment and viral infection, and it has been suggested to play an important role in IFN-dependent antiviral responses. …”
Publicado 2022
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2309por Osakabe, Yuki, Yamaguchi, Fumihiro, Suzuki, Ayako, Kitano, Haruka, Hiraiwa, Mina, Shiratori, Yo, Onozaki, Shota, Nakamoto, Mari, Kawamura, Saori, Kosuge, Miku, Atarashi, Kenji, Cho, Hidekazu, Shimizu, Shohei, Fujishima, Akira, Shikama, Yusuke“…BACKGROUND: The interferon (IFN)-γ release assay (IGRA) has recently been established as a method to evaluate the infection status of tuberculosis instead of the tuberculin skin test. …”
Publicado 2022
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2310por Willemsen, Lisa, Chen, Hung-Jen, van Roomen, Cindy P. A. A., Griffith, Guillermo R., Siebeler, Ricky, Neele, Annette E., Kroon, Jeffrey, Hoeksema, Marten A., de Winther, Menno P. J.“…Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential role in antiviral responses and inflammatory activation and have been shown to promote atherosclerosis. …”
Publicado 2022
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2311por Sandmann, Lisa, Yurdaydin, Cihan, Deterding, Katja, Heidrich, Benjamin, Hardtke, Svenja, Lehmann, Patrick, Bremer, Birgit, Manns, Michael P., Cornberg, Markus, Wedemeyer, Heiner, Maasoumy, Benjamin“…Standard treatment of hepatitis delta virus (HDV) infection remains pegylated‐interferon alfa (peg‐IFNα) in most centers, which is not only associated with rather low efficacy but several adverse events. …”
Publicado 2021
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2312por Tuffs, Stephen W., Goncheva, Mariya I., Xu, Stacey X., Craig, Heather C., Kasper, Katherine J., Choi, Joshua, Flannagan, Ronald S., Kerfoot, Steven M., Heinrichs, David E., McCormick, John K.“…We demonstrate that SAgs contribute to S. aureus bacteremia by massively increasing bacterial burden in the liver, and this was mediated by CD4(+) T cells that produced interferon gamma (IFN-γ) to high levels in a SAg-dependent manner. …”
Publicado 2022
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2313por Alidjinou, Enagnon Kazali, Hirabidian, Mickael, Rabat, Anthony, Ouafi, Mahdi, Nekoua, Magloire Pandoua, Sane, Famara, Poissy, Julien, Hober, Didier“…Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. …”
Publicado 2022
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2314por Malikov, Viacheslav, Meade, Nathan, Simons, Lacy M., Hultquist, Judd F., Naghavi, Mojgan H.“…Here, we show that, although modulating FEZ1 expression also impacts infection by large DNA viruses in human microglia, macrophages, and fibroblasts, this broad antiviral phenotype is associated with the pre-induction of interferon-stimulated genes (ISGs) in a STING-independent manner. …”
Publicado 2022
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2315“…Damage- or stress-mediated activation of nucleic acid-sensing pathways triggers type I interferon (IFN-I) responses that activate innate immune cells and natural killer cells, promote maturation of dendritic cells, and stimulate adaptive immunity. …”
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2316“…Dysregulation of type I interferons (IFNs) has been implicated in the pathogenesis of systemic lupus erythematosus (SLE) since the late 1970s. …”
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2317por Sumida, Tomokazu S., Dulberg, Shai, Schupp, Jonas C., Lincoln, Matthew R., Stillwell, Helen A., Axisa, Pierre-Paul, Comi, Michela, Unterman, Avraham, Kaminski, Naftali, Madi, Asaf, Kuchroo, Vijay K., Hafler, David A.“…Here we show that type 1 interferon (IFN-I) regulates co-inhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting TIGIT expression. …”
Publicado 2022
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2318por Kumata, Ryuichi, Iwanami, Shoya, Mar, Katrina B., Kakizoe, Yusuke, Misawa, Naoko, Nakaoka, Shinji, Koyanagi, Yoshio, Perelson, Alan S., Schoggins, John W., Iwami, Shingo, Sato, Kei“…TF viruses are more resistant to interferon-alpha (IFN-α)-mediated antiviral effects than CC virus, however, its virological relevance in infected individuals remains unclear. …”
Publicado 2022
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2319“…Interferon-beta-1a (IFN-β-1a) can diminish the symptoms of relapsing-remitting multiple sclerosis. …”
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2320por Lee, Amanda J., Feng, Emily, Chew, Marianne V., Balint, Elizabeth, Poznanski, Sophie M., Giles, Elizabeth, Zhang, Ali, Marzok, Art, Revill, Spencer D., Vahedi, Fatemeh, Dubey, Anisha, Ayaub, Ehab, Jimenez-Saiz, Rodrigo, McGrath, Joshua J. C., Ritchie, Tyrah M., Jordana, Manel, Jonigk, Danny D., Ackermann, Maximilian, Ask, Kjetil, Miller, Matthew, Richards, Carl D., Ashkar, Ali A.“…While the role of type I interferons (IFNs) in early control of viral replication is clear, less is known about how IFNs can regulate the development of immunopathology and affect disease outcomes. …”
Publicado 2022
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