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  1. 2341
    “…Exploring the mechanistic basis of AM training, we identified a critical role of type 1 interferon signaling and found that inhibition of fatty acid oxidation and glutaminolysis significantly attenuated the training effect. …”
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    Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
  2. 2342
    “…OBJECTIVES: To perform a systematic review and meta-analysis of interferon and endocrine side effects, including their incidence, evaluation, and management. …”
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    A systematic review and meta-analysis of endocrine-related adverse events associated with interferon
  3. 2343
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    Type I interferons during host–fungus interactions: Is antifungal immunity going viral?
  4. 2344
    “…Furthermore, we found that STAG2 deficiency results in robust interferon (IFN) expression. Subsequently, we found that STAG2 deficiency results in the activation of JAK-STAT signaling and the expression of IFN stimulated gene (ISG), which establish an antiviral state. …”
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    Stromal Antigen 2 Deficiency Induces Interferon Responses and Restricts Porcine Deltacoronavirus Infection
  5. 2345
    por Mungin, James W., Chen, Xin, Liu, Bindong
    Publicado 2022
    “…For the first time, our data show that interferon epsilon inhibits ZIKV replication. Collectively, our results in this study provide a novel perspective on the viral susceptibility and replication dynamics during ZIKV infection in the human vaginal epithelium. …”
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    Interferon Epsilon Signaling Confers Attenuated Zika Replication in Human Vaginal Epithelial Cells
  6. 2346
    “…METHODS: An exploratory analysis using mass cytometry was conducted of MAPK/ERK and JAK/STAT signaling pathways in peripheral blood mononuclear cells (PBMC) from 16 female medication free pSS patients (8 anti-Sjögren’s syndrome-related antigen A negative/SSA- and 8 SSA+) and 8 female age-matched healthy donors after stimulation with interferons (IFNs). RESULTS: We found significant differences in the frequencies of memory B cells, CD8+ T central and effector memory cells and terminally differentiated CD4+ T cells among the healthy donors and patient subgroups. …”
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    Aberrant signaling of immune cells in Sjögren’s syndrome patient subgroups upon interferon stimulation
  7. 2347
    por Mair, Nina K., Hale, Benjamin G.
    Publicado 2022
    “…The human type I interferon (IFN) system is central to innate immune defense, and is essential to protect individuals against severe viral disease. …”
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    Ultra-Rare BRD9 Loss-of-Function Variants Limit the Antiviral Action of Interferon
  8. 2348
    “…Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. …”
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    Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
  9. 2349
    “…Moreover, the level of the antiviral cytokine interferon (IFN)-α was also increased by ACE-3 and ACE-4 in Meg-01 cells after DENV infection. …”
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    Antrodia cinnamomea Suppress Dengue Virus Infection through Enhancing the Secretion of Interferon-Alpha
  10. 2350
    “…Activation of the type 1 interferon (T1 IFN) pathway has been implicated in the pathogenesis of systemic sclerosis (SSc) by an increasing number of studies, most of which share key findings with similar studies in systemic lupus erythematosus (SLE). …”
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    Type 1 interferon activation in systemic sclerosis: a biomarker, a target or the culprit
  11. 2351
    “…Using single-cell RNA-sequencing, we identified interferon (IFN)-responsive oligodendrocytes, which localize in proximity to CD8(+) T cells in aging white matter. …”
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    CD8(+) T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
  12. 2352
    “…Chloroplast genetic engineering is a convenient method for the production of recombinant proteins by increasing the expression level of transgenes. Interferon-beta (IFN-β) is a member of type I interferons that possess some pharmaceutical properties. …”
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    Overexpression of the recombinant human interferon-beta (rhIFN-β) gene in tobacco chloroplasts
  13. 2353
    “…Interferons (IFNs) are pleiotropic cytokines originally identified for their antiviral activity. …”
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    Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID
  14. 2354
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    Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
  15. 2355
    “…The purpose of this review is to highlight the enormous impact of innate immunity and mostly interferons in SLE.…”
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    Interferon in systemic lupus erythematosus—A halfway between monogenic autoinflammatory and autoimmune disease
  16. 2356
    “…Evidence is accumulating that the transcription factor STAT2, a downstream effector of type I interferon (IFN-I) signaling, can either inhibit or promote tumorigenesis depending on the unique environment presented by each type of cancer. …”
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    The duality of STAT2 mediated type I interferon signaling in the tumor microenvironment and chemoresistance
  17. 2357
    “…Here, we firstly reported a patient diagnosed as acquired TTP after pegylated interferon therapy for hepatitis B and COVID-19 vaccination. …”
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    Thrombotic thrombocytopenic purpura developed after pegylated interferon treatment for hepatitis B infection
  18. 2358
    “…Here, we show that the interferon-inducible (IFN-inducible) protein viperin drove metabolic alteration in cancer cells. …”
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    The interferon-inducible protein viperin controls cancer metabolic reprogramming to enhance cancer progression
  19. 2359
    “…Furthermore, we revealed large-scale transcriptional repression in microglia isolated from the stressed brain, including many interferon (IFN)-regulated genes (IRGs) and some encompassing DNA repeats. …”
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    Microglia-specific transcriptional repression of interferon-regulated genes after prolonged stress in mice
  20. 2360
    “…BACKGROUND: Type I interferon (IFN) inhibits virus infection through multiple processes. …”
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    Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis
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