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2341Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signalingpor Zahalka, Sophie, Starkl, Philipp, Watzenboeck, Martin L., Farhat, Asma, Radhouani, Mariem, Deckert, Florian, Hladik, Anastasiya, Lakovits, Karin, Oberndorfer, Felicitas, Lassnig, Caroline, Strobl, Birgit, Klavins, Kristaps, Matsushita, Mai, Sanin, David E., Grzes, Katarzyna M., Pearce, Edward J., Gorki, Anna-Dorothea, Knapp, Sylvia“…Exploring the mechanistic basis of AM training, we identified a critical role of type 1 interferon signaling and found that inhibition of fatty acid oxidation and glutaminolysis significantly attenuated the training effect. …”
Publicado 2022
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2342A systematic review and meta-analysis of endocrine-related adverse events associated with interferonpor Wang, Linghuan, Li, Binqi, Zhao, He, Wu, Peixin, Wu, Qingzhen, Chen, Kang, Mu, Yiming“…OBJECTIVES: To perform a systematic review and meta-analysis of interferon and endocrine side effects, including their incidence, evaluation, and management. …”
Publicado 2022
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2344por Wu, Yang, Zhang, Hongling, Chen, Jianfei, Shi, Zhaorong, Li, Mingwei, Zhao, Ying, Shi, Hongyan, Shi, Da, Guo, Longjun, Feng, Li“…Furthermore, we found that STAG2 deficiency results in robust interferon (IFN) expression. Subsequently, we found that STAG2 deficiency results in the activation of JAK-STAT signaling and the expression of IFN stimulated gene (ISG), which establish an antiviral state. …”
Publicado 2022
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2345“…For the first time, our data show that interferon epsilon inhibits ZIKV replication. Collectively, our results in this study provide a novel perspective on the viral susceptibility and replication dynamics during ZIKV infection in the human vaginal epithelium. …”
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2346por Sarkar, Irene, Davies, Richard, Aarebrot, Anders K., Solberg, Silje M., Petrovic, Aleksandra, Joshi, Anagha M., Bergum, Brith, Brun, Johan G., Hammenfors, Daniel, Jonsson, Roland, Appel, Silke“…METHODS: An exploratory analysis using mass cytometry was conducted of MAPK/ERK and JAK/STAT signaling pathways in peripheral blood mononuclear cells (PBMC) from 16 female medication free pSS patients (8 anti-Sjögren’s syndrome-related antigen A negative/SSA- and 8 SSA+) and 8 female age-matched healthy donors after stimulation with interferons (IFNs). RESULTS: We found significant differences in the frequencies of memory B cells, CD8+ T central and effector memory cells and terminally differentiated CD4+ T cells among the healthy donors and patient subgroups. …”
Publicado 2022
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2347“…The human type I interferon (IFN) system is central to innate immune defense, and is essential to protect individuals against severe viral disease. …”
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2348por Kalliara, Eirini, Kardynska, Malgorzata, Bagnall, James, Spiller, David G., Müller, Werner, Ruckerl, Dominik, Śmieja, Jarosław, Biswas, Subhra K., Paszek, Pawel“…Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. …”
Publicado 2022
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2349por Chen, Yi-Ju, Tsao, Yu-Cian, Ho, Tzu-Chuan, Puc, Irwin, Chen, Chia-Chang, Perng, Guey-Chuen, Lien, Hsiu-Man“…Moreover, the level of the antiviral cytokine interferon (IFN)-α was also increased by ACE-3 and ACE-4 in Meg-01 cells after DENV infection. …”
Publicado 2022
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2350por Kakkar, Vishal, Assassi, Shervin, Allanore, Yannick, Kuwana, Masataka, Denton, Christopher P., Khanna, Dinesh, Del Galdo, Francesco“…Activation of the type 1 interferon (T1 IFN) pathway has been implicated in the pathogenesis of systemic sclerosis (SSc) by an increasing number of studies, most of which share key findings with similar studies in systemic lupus erythematosus (SLE). …”
Publicado 2022
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2351por Kaya, Tuğberk, Mattugini, Nicola, Liu, Lu, Ji, Hao, Cantuti-Castelvetri, Ludovico, Wu, Jianping, Schifferer, Martina, Groh, Janos, Martini, Rudolf, Besson-Girard, Simon, Kaji, Seiji, Liesz, Arthur, Gokce, Ozgun, Simons, Mikael“…Using single-cell RNA-sequencing, we identified interferon (IFN)-responsive oligodendrocytes, which localize in proximity to CD8(+) T cells in aging white matter. …”
Publicado 2022
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2352“…Chloroplast genetic engineering is a convenient method for the production of recombinant proteins by increasing the expression level of transgenes. Interferon-beta (IFN-β) is a member of type I interferons that possess some pharmaceutical properties. …”
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2353“…Interferons (IFNs) are pleiotropic cytokines originally identified for their antiviral activity. …”
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2354por Sohail, Aaqib, Iqbal, Azeem A., Sahini, Nishika, Chen, Fangfang, Tantawy, Mohamed, Waqas, Syed F. H., Winterhoff, Moritz, Ebensen, Thomas, Schultz, Kristin, Geffers, Robert, Schughart, Klaus, Preusse, Matthias, Shehata, Mahmoud, Bähre, Heike, Pils, Marina C., Guzman, Carlos A., Mostafa, Ahmed, Pleschka, Stephan, Falk, Christine, Michelucci, Alessandro, Pessler, FrankEnlace del recurso
Publicado 2022
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2355“…The purpose of this review is to highlight the enormous impact of innate immunity and mostly interferons in SLE.…”
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2356“…Evidence is accumulating that the transcription factor STAT2, a downstream effector of type I interferon (IFN-I) signaling, can either inhibit or promote tumorigenesis depending on the unique environment presented by each type of cancer. …”
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2357por Mei, Shuqin, Feng, Yun, Cui, Linlin, Chen, Jing, Mao, Zhiguo, Zhao, Xuezhi, Mei, Changlin, Qian, Yixin“…Here, we firstly reported a patient diagnosed as acquired TTP after pegylated interferon therapy for hepatitis B and COVID-19 vaccination. …”
Publicado 2022
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2358por Choi, Kyung Mi, Kim, Jeong Jin, Yoo, Jihye, Kim, Ku Sul, Gu, Youngeun, Eom, John, Jeong, Haengdueng, Kim, Kyungeun, Nam, Ki Taek, Park, Young Soo, Chung, Joon-Yong, Seo, Jun-Young“…Here, we show that the interferon-inducible (IFN-inducible) protein viperin drove metabolic alteration in cancer cells. …”
Publicado 2022
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2359por Zhang, Yuan, Dong, Yuhao, Zhu, Yueyan, Sun, Daijing, Wang, Shunying, Weng, Jie, Zhu, Yue, Peng, Wenzhu, Yu, Bo, Jiang, Yan“…Furthermore, we revealed large-scale transcriptional repression in microglia isolated from the stressed brain, including many interferon (IFN)-regulated genes (IRGs) and some encompassing DNA repeats. …”
Publicado 2022
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2360por An, Ni, Ge, Qinghua, Shao, Huihan, Li, Quanjie, Guo, Fei, Liang, Chen, Li, Xiaoyu, Yi, Dongrong, Yang, Long, Cen, Shan“…BACKGROUND: Type I interferon (IFN) inhibits virus infection through multiple processes. …”
Publicado 2022
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